| GADD45B in the ventral hippocampal CA1 modulates aversive memory acquisition and spatial cognition. | GADD45B in the ventral hippocampal CA1 modulates aversive memory acquisition and spatial cognition.
Huang M, Tao X, Bao J, Wang J, Gong X, Luo L, Pan S, Yang R, Gui Y, Zhou H, Xia Y, Yang Y, Sun B, Liu W, Shu X. | 05/8/2024 |
| Has-miR-300-GADD45B promotes melanoma growth via cell cycle. | Has-miR-300-GADD45B promotes melanoma growth via cell cycle.
Chen L, Fang C, Yuan X, Liu M, Wu P, Zhong L, Chen Z., Free PMC Article | 12/28/2023 |
| Key Roles of p53 Signaling Pathway-Related Factors GADD45B and SERPINE1 in the Occurrence and Development of Gastric Cancer. | Key Roles of p53 Signaling Pathway-Related Factors GADD45B and SERPINE1 in the Occurrence and Development of Gastric Cancer.
Li Y, Shen L, Tao K, Xu G, Ji K., Free PMC Article | 09/27/2023 |
| Expression of GADD45B in Renal Tissue of Children with IgA Nephropathy and Correlation with Mesangial Hypercellularity. | Expression of GADD45B in Renal Tissue of Children with IgA Nephropathy and Correlation with Mesangial Hypercellularity.
Li C, Wei A, Qin Y. | 09/20/2023 |
| GADD45B regulates the carcinogenesis process of chronic atrophic gastritis and the metabolic pathways of gastric cancer. | GADD45B regulates the carcinogenesis process of chronic atrophic gastritis and the metabolic pathways of gastric cancer.
Xu W, Jiang T, Shen K, Zhao D, Zhang M, Zhu W, Liu Y, Xu C., Free PMC Article | 08/30/2023 |
| Single-cell transcriptomics identifies Gadd45b as a regulator of herpesvirus-reactivating neurons. | Single-cell transcriptomics identifies Gadd45b as a regulator of herpesvirus-reactivating neurons.
Hu HL, Srinivas KP, Wang S, Chao MV, Lionnet T, Mohr I, Wilson AC, Depledge DP, Huang TT., Free PMC Article | 03/19/2022 |
| Growth arrest and DNA damage-inducible proteins (GADD45) in psoriasis. | Growth arrest and DNA damage-inducible proteins (GADD45) in psoriasis.
Rodríguez-Jiménez P, Fernández-Messina L, Ovejero-Benito MC, Chicharro P, Vera-Tomé P, Vara A, Cibrian D, Martínez-Fleta P, Jiménez-Fernández M, Sánchez-García I, Llamas-Velasco M, Abad-Santos F, Sánchez-Madrid F, Dauden E, de la Fuente H., Free PMC Article | 11/13/2021 |
| GADD45B Transcript Is a Prognostic Marker in Papillary Thyroid Carcinoma Patients Treated With Total Thyroidectomy and Radioiodine Therapy. | GADD45B Transcript Is a Prognostic Marker in Papillary Thyroid Carcinoma Patients Treated With Total Thyroidectomy and Radioiodine Therapy.
Barros-Filho MC, de Mello JBH, Marchi FA, Pinto CAL, da Silva IC, Damasceno PKF, Soares MBP, Kowalski LP, Rogatto SR., Free PMC Article | 07/24/2021 |
| We found that GADD45B is indispensable for DNA damage protection and survival in stem cells. Thus, we describe an easy and efficient protocol of DNA-free gene editing of hard-to-target transcripts and enrichment of gene-modified cells that are generally difficult to transfect. | Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.
Nasri M, Mir P, Dannenmann B, Amend D, Skroblyn T, Xu Y, Schulze-Osthoff K, Klimiankou M, Welte K, Skokowa J., Free PMC Article | 01/11/2020 |
| demonstrate the protective role of GADD45beta in sepsis and the results suggest that GADD45beta could be used as a novel therapeutic target to cure sepsis | GADD45β plays a protective role in acute lung injury by regulating apoptosis in experimental sepsis in vivo.
Moon SJ, Kim HY, Kim YH, Kim KS, Noh JR, Kim HJ, Choi JH, Hwang JH, Lee CH. | 10/5/2019 |
| Down-regulation of GADD45beta can reduce the colony-forming ability of PC9 cells, promote the cell apoptosis, and enhance the sensitivity of PC9 cells to gefitinib | [Effect of down-regulation of growth arrest and DNA damage inducible protein 45β on PC9 lung adenocarcinoma cells].
Hu H, Que K, Peng H, Liu J, Han C, Zhang N, Hou T, Hu C, Ma J. | 02/16/2019 |
| Although GADD45B is elevated in prostate cancer tissues, levels of GADD45B in prostate tumor tissues are reduced at late stage of tumor invasion, and higher levels of GADD45B predict better survivals of prostate cancer patients. | Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B.
Huang H, Wang Q, Du T, Lin C, Lai Y, Zhu D, Wu W, Ma X, Bai S, Li Z, Liu L, Li Q. | 02/9/2019 |
| High GADD45B expression is associated with cancer. | GADD45β Loss Ablates Innate Immunosuppression in Cancer.
Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D, D'Andrea D, Di Francesco B, De Maglie M, Begalli F, Tornatore L, Papa S, Lawrence T, Forbes SJ, Sica A, Alesse E, Zazzeroni F, Franzoso G., Free PMC Article | 01/19/2019 |
| The assessment of the interaction between GADD45beta and MKK7 and the elucidation of the recognition surfaces between DTP3 and MKK7 significantly advance the understanding of the mechanism underlying the inhibition of the GADD45beta/MKK7 interaction by DTP3 and pave the way to the design of small-molecule DTP3 analogues. | Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry.
Rega C, Russo R, Focà A, Sandomenico A, Iaccarino E, Raimondo D, Milanetti E, Tornatore L, Franzoso G, Pedone PV, Ruvo M, Chambery A., Free PMC Article | 09/29/2018 |
| We propose a signaling cascade involving ARID1A, GADD45B and DUSP1 as mediators of the romidepsin effects in GCC cells. | A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment.
Nettersheim D, Jostes S, Fabry M, Honecker F, Schumacher V, Kirfel J, Kristiansen G, Schorle H., Free PMC Article | 03/3/2018 |
| present study provides evidence that variations in GADD45B rs2024144T, MAPK14 rs3804451A and GADD45A rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer | Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer.
Jia M, Zhu M, Wang M, Sun M, Qian J, Ding F, Chang J, Wei Q., Free PMC Article | 01/6/2018 |
| These findings demonstrate that 19p13.3-GADD45B rs7354 variant and interaction between 19p13.3-GADD45B rs3783501 and 19q13.3-CD3EAP rs967591 may play a role in association with smoke-exposed lung cancer among Chinese. | 19p13.3-GADD45B common variants and 19q13.3-PPP1R13L and 19q13.3-CD3EAP in lung cancer risk among Chinese.
Hou W, Yin J, Vogel U, Sun Z, Liang D. | 11/11/2017 |
| We used a new approach to search for human genes repressed by small nucleic acids (microRNAs) expressed by a gammaherpesvirus (KSHV), which identified a gene called GADD45B as a target of microRNAs. Repression of GADD45B, which is expressed in response to DNA damage, benefited survival of infected cells in response to a DNA damage response. This information could be used to design new treatments for herpesvirus infections | Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosis.
Liu X, Happel C, Ziegelbauer JM., Free PMC Article | 05/20/2017 |
| Gadd45beta could be a suitable biomarker of cardiomyocytes apoptosis in newborns experiencing hypoxia in the first day of life, as its highest tissue immunoexpression around at the first six hours after birth. | Immunoexpression of GADD45β in the myocardium of newborns experiencing perinatal hypoxia.
Simões MA, Pabis FC, de Freitas AK, de Azevedo ML, Ronchi DC, de Noronha L. | 04/8/2017 |
| Nrf2-Gadd45b signaling axis exhibited a protective role in antimony trioxide-induced cell apoptosis. | The protective role of Nrf2-Gadd45b against antimony-induced oxidative stress and apoptosis in HEK293 cells.
Jiang X, An Z, Lu C, Chen Y, Du E, Qi S, Yang K, Zhang Z, Xu Y. | 02/4/2017 |
| our data demonstrate that C/EBPbeta plays a central role in controlling Gadd45beta gene expression in articular chondrocytes | CCAAT/enhancer binding protein β (C/EBPβ) regulates the transcription of growth arrest and DNA damage-inducible protein 45 β (GADD45β) in articular chondrocytes.
Shimada H, Otero M, Tsuchimochi K, Yamasaki S, Sakakima H, Matsuda F, Sakasegawa M, Setoguchi T, Xu L, Goldring MB, Tanimoto A, Komiya S, Ijiri K. | 01/28/2017 |
| Gadd45B protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review) | Gadd45 in the liver: signal transduction and transcriptional mechanisms.
Tian J, Locker J. | 02/22/2014 |
| The gadd45b gene has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event. (Review) | Gadd45 in modulation of solid tumors and leukemia.
Hoffman B, Liebermann DA. | 02/22/2014 |
| as such may play an unappreciated role in tumorigenesis. The exact mechanism of GADD45B inactivation and overexpression requires further investigation. GADD45B could be a potential therapeutic target for CRC treatment in future | Abnormal expression of GADD45B in human colorectal carcinoma.
Wang L, Xiao X, Li D, Chi Y, Wei P, Wang Y, Ni S, Tan C, Zhou X, Du X., Free PMC Article | 04/6/2013 |
| Cadmium chloride can induce DNA damage and increase expression levels of the gadd153 and gadd45beta promoters in HepG2 cells. | [The effects of the cadmium chloride on the DNA damage and the expression level of gadd gene in HepG2 cell line].
Zhang R, Niu YJ, Zhang ZJ, Chen Q, Guo HC, Zhao J, Li Y, Fan LG. | 09/22/2012 |