| The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo. | The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
Lübke S, Braukmann C, Rexer KH, Cigoja L, Rout P, Önel SF., Free PMC Article | 01/10/2024 |
| Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability. | Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.
Rogers EM, Allred SC, Peifer M., Free PMC Article | 01/1/2022 |
| Htt is a repressor of Abl activity required for APP-induced axonal growth. | Htt is a repressor of Abl activity required for APP-induced axonal growth.
Marquilly C, Busto GU, Leger BS, Boulanger A, Giniger E, Walker JA, Fradkin LG, Dura JM., Free PMC Article | 04/24/2021 |
| Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions. | Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions.
Yu HH, Zallen JA., Free PMC Article | 01/23/2021 |
| Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin. | Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin.
Clarke A, McQueen PG, Fang HY, Kannan R, Wang V, McCreedy E, Wincovitch S, Giniger E., Free PMC Article | 01/23/2021 |
| Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase. | Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase.
Clarke A, McQueen PG, Fang HY, Kannan R, Wang V, McCreedy E, Buckley T, Johannessen E, Wincovitch S, Giniger E., Free PMC Article | 01/23/2021 |
| BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis | BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis.
Kim N, Kim S, Nahm M, Kopke D, Kim J, Cho E, Lee MJ, Lee M, Kim SH, Broadie K, Lee S., Free PMC Article | 04/13/2019 |
| Notch-Abl axonal signaling requires proteolytic cleavage events that initiate canonical Notch signaling. Some Notch protein is tyrosine phosphorylated, this form of the protein is selectively associated with Disabled and Trio, and relevant tyrosines are essential for Notch-dependent axon patterning but not for canonical Notch-dependent regulation of cell fate. | Tyrosine phosphorylation and proteolytic cleavage of Notch are required for non-canonical Notch/Abl signaling in Drosophila axon guidance.
Kannan R, Cox E, Wang L, Kuzina I, Gu Q, Giniger E., Free PMC Article | 04/14/2018 |
| The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase. | The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.
Kannan R, Song JK, Karpova T, Clarke A, Shivalkar M, Wang B, Kotlyanskaya L, Kuzina I, Gu Q, Giniger E., Free PMC Article | 09/9/2017 |
| In conjunction with its receptor Neurotactin (Nrt) and the effector kinase Abelson tyrosine kinase (Abl), Ama is necessary in parallel to the cell-autonomous Dfd pathway for the correct specification of the maxillary identity of NB6-4 | Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.
Becker H, Renner S, Technau GM, Berger C., Free PMC Article | 08/6/2016 |
| Dysregulated Dscam binds to Abl through its cytoplasmic domain to enlarge presynaptic arbors in the Drosophila fragile X syndrome model. | Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors.
Sterne GR, Kim JH, Ye B., Free PMC Article | 01/16/2016 |
| Abl/Ena signaling controls the subcellular architecture of the Golgi complex in Drosophila photoreceptor neurons through its regulation of the Golgi-associated actin cytoskeleton. | The Abl/enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons.
Kannan R, Kuzina I, Wincovitch S, Nowotarski SH, Giniger E., Free PMC Article | 06/20/2015 |
| Abl is an essential regulator for myocyte. | Distinct effects of Abelson kinase mutations on myocytes and neurons in dissociated Drosophila embryonic cultures: mimicking of high temperature.
Liu L, Wu CF., Free PMC Article | 09/20/2014 |
| Abl plays a role in the organization of filamentous actin and the redistribution of the junctional protein beta-catenin at the wound margin during embryonic wound repair. | Automated multidimensional image analysis reveals a role for Abl in embryonic wound repair.
Zulueta-Coarasa T, Tamada M, Lee EJ, Fernandez-Gonzalez R. | 09/6/2014 |
| Data find that Abl interacts both physically and genetically with the Netrin receptor Frazzled, and that disrupting this interaction prevents Abl from promoting midline axon crossing. | Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits.
O'Donnell MP, Bashaw GJ., Free PMC Article | 08/31/2013 |
| Abl is required for photoreceptor cell fate maintenance, as Abl mutant photoreceptors lose neuronal markers during late pupal stages but do not re-enter a proliferative state or undergo apoptosis. | The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors.
Xiong W, Morillo SA, Rebay I., Free PMC Article | 02/2/2013 |
| Results reveal a prominent role for Abl in coordinating multiple aspects of photoreceptor morphogenesis. | Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning.
Xiong W, Rebay I., Free PMC Article | 12/17/2011 |
| During the degradation of WAVE, Hem function is opposite to that of and downstream of Abl. | The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase.
Zhu Z, Bhat KM., Free PMC Article | 10/29/2011 |
| The main upstream stimulus activating the c-Abl/p73 pathway and neuronal apoptosis in Niemann-Pick type C neurons is oxidative stress. | Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons.
Klein A, Maldonado C, Vargas LM, Gonzalez M, Robledo F, Perez de Arce K, Muñoz FJ, Hetz C, Alvarez AR, Zanlungo S. | 10/1/2011 |
| Data suggest a model in which CLASP and Msps converge in an antagonistic balance in the Abl signaling pathway. | Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila.
Lowery LA, Lee H, Lu C, Murphy R, Obar RA, Zhai B, Schedl M, Van Vactor D, Zhan Y., Free PMC Article | 02/26/2011 |
| Fra activity is required to correctly regulate Abl-dependent cytoskeletal dynamics underlying commissure formation | In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS.
Dorsten JN, Varughese BE, Karmo S, Seeger MA, VanBerkum MF., Free PMC Article | 01/15/2011 |
| Dab is a bona fide component of Abl signaling in Drosophila. | Disabled is a bona fide component of the Abl signaling network.
Song JK, Kannan R, Merdes G, Singh J, Mlodzik M, Giniger E., Free PMC Article | 11/13/2010 |
| dAbl positively regulates the Fz/Dishevelled (Dsh) PCP pathway without affecting canonical Wnt/Wg-Fz signaling | Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.
Singh J, Yanfeng WA, Grumolato L, Aaronson SA, Mlodzik M., Free PMC Article | 10/23/2010 |
| Data suggest that abi and Abl have an antagonistic interaction in Drosophila axonogenesis and synaptogenesis, which possibly occurs through the modulation of F-actin reorganization. | Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis.
Lin TY, Huang CH, Kao HH, Liou GG, Yeh SR, Cheng CM, Chen MH, Pan RL, Juang JL. | 01/21/2010 |
| Results establish that PTP61F and dAbl ensure proper actin organization through the coordinated and reversible tyrosine phosphorylation of Kette. | Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl.
Ku HY, Wu CL, Rabinow L, Chen GC, Meng TC., Free PMC Article | 01/21/2010 |