| Dynein, Mud and Asp operate sequentially during the cell cycle to ensure efficient centrosome-spindle coupling in mitosis, thereby preventing centrosome mis-segregation to maintain centrosome number. | Sequential activities of Dynein, Mud and Asp in centrosome-spindle coupling maintain centrosome number upon mitosis.
Bosveld F, Ainslie A, Bellaïche Y. | 06/9/2018 |
| mutation of mushroom body defect (mud) dramatically enhances the phenotype of Netrin or frazzled mutants, resulting in many more axons failing to cross the midline, although mutations in mud alone have little effect. | Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.
Cate MS, Gajendra S, Alsbury S, Raabe T, Tear G, Mitchell KJ., Free PMC Article | 08/6/2016 |
| Data indicate that mushroom body defect protein (Mud) co-localized with centromeres, Klarsicht protein and Klaroid protein. | Microtubule-driven nuclear rotations promote meiotic chromosome dynamics.
Christophorou N, Rubin T, Bonnet I, Piolot T, Arnaud M, Huynh JR. | 03/19/2016 |
| Mud, a microtubule binding protein regulating spindle orientation, is involved in binucleation of Drosophila male accessory gland cells. | Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells.
Taniguchi K, Kokuryo A, Imano T, Minami R, Nakagoshi H, Adachi-Yamada T., Free PMC Article | 10/3/2015 |
| Insc-Pins complex requires Galphai for partial activity and that the complex specifically recruits Dlg but not Mud. | Inscuteable regulates the Pins-Mud spindle orientation pathway.
Mauser JF, Prehoda KE., Free PMC Article | 06/2/2012 |
| Inscuteable and NuMA [Mud] proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. | Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.
Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M., Free PMC Article | 02/25/2012 |
| Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation. | Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.
Wee B, Johnston CA, Prehoda KE, Doe CQ., Free PMC Article | 01/14/2012 |
| Mud depletion caused chromosome misalignment defects that resembled the defects of Rab5 RNAi cells, and double-knockdown experiments indicated that the two proteins function in a linear pathway. | Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis.
Capalbo L, D'Avino PP, Archambault V, Glover DM., Free PMC Article | 12/31/2011 |
| these findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during neuroblasts asymmetric division. | An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts.
Wang C, Li S, Januschke J, Rossi F, Izumi Y, Garcia-Alvarez G, Gwee SS, Soon SB, Sidhu HK, Yu F, Matsuzaki F, Gonzalez C, Wang H. | 11/26/2011 |
| Results describe a Frizzled-Dishevelled-NuMA/Mud pathway that orients division from Drosophila to vertebrates. | The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish.
Ségalen M, Johnston CA, Martin CA, Dumortier JG, Prehoda KE, David NB, Doe CQ, Bellaïche Y., Free PMC Article | 01/1/2011 |
| Using a method based on the conditioned reflex suppression of courtship. Memory defects were seen in mud mutants. | The ability of Drosophila mutants with defects in the central complex and mushroom bodies to learn and form memories.
Sitnik NA, Tokmacheva EV, Savvateeva-Popova EV. | 01/21/2010 |
| Mud is required for the formation and/or stability of spindle apparatus. | The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes.
Yu JX, Guan Z, Nash HA., Free PMC Article | 01/21/2010 |