| Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic beta-catenin. | Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin.
Erazo-Oliveras A, Muñoz-Vega M, Mlih M, Thiriveedi V, Salinas ML, Rivera-Rodríguez JM, Kim E, Wright RC, Wang X, Landrock KK, Goldsby JS, Mullens DA, Roper J, Karpac J, Chapkin RS., Free PMC Article | 07/24/2023 |
| Novel requirement for APC in Axin regulation through phosphorylation both prevents signaling in the Wnt-off state and promotes signaling immediately following Wnt stimulation. | Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.
Tacchelly-Benites O, Wang Z, Yang E, Benchabane H, Tian A, Randall MP, Ahmed Y., Free PMC Article | 07/21/2018 |
| in the adult intestine, Ebd acts independently of Ewg in physiological Wnt signaling, but cooperates with Ewg to induce the hyperactivation of Wnt target gene expression following Apc1 loss. These findings have relevance for human tumorigenesis, as Jerky (JRK/JH8), the human Ebd homolog, promotes Wnt pathway hyperactivation and is overexpressed in colorectal, breast, and ovarian cancers | Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.
Tian A, Benchabane H, Wang Z, Zimmerman C, Xin N, Perochon J, Kalna G, Sansom OJ, Cheng C, Cordero JB, Ahmed Y., Free PMC Article | 08/5/2017 |
| We conclude that even in the unstimulated state, a pool of Axin forms membrane-proximal puncta that are dependent on Apc, and that membrane association regulates both Axin levels and Axin's role in the rapid activation of signaling that follows Wnt exposure. | Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.
Wang Z, Tacchelly-Benites O, Yang E, Ahmed Y., Free PMC Article | 05/13/2017 |
| Data indicate that Ras is not required for Wnt signaling activation after APC loss. | APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.
Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R. | 07/27/2013 |
| Drosophila and vertebrate APCs exhibit highly related activities and mechanisms and directly collaborate with formins such as diaphanous. | Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly.
Jaiswal R, Stepanik V, Rankova A, Molinar O, Goode BL, McCartney BM., Free PMC Article | 07/13/2013 |
| co-expression experiments reveal that APC displaces Dishevelled from Axin assemblies, promoting degradasome over signalosome formation in the absence of Wnts | The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled.
Mendoza-Topaz C, Mieszczanek J, Bienz M., Free PMC Article | 06/29/2013 |
| Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. | Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut.
Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ. | 02/2/2013 |
| Data show that a loss of function for dapc1 or both dapc1 and dapc2 (dapc) in ovary border (BC) and adjacent follicle cells impaired BC delamination, and this mutant phenotype can be rescued upon overexpression of either dapc1 or dapc2. | Drosophila apc regulates delamination of invasive epithelial clusters.
De Graeve FM, Van de Bor V, Ghiglione C, Cerezo D, Jouandin P, Ueda R, Shashidhara LS, Noselli S. | 09/22/2012 |
| spindle assembly checkpoint is not responsible for the inability of APC(Fzy) to target cyclin B and promote anaphase in metaphase II arrested eggs from cort mutant females | Evidence that the spindle assembly checkpoint does not regulate APC(Fzy) activity in Drosophila female meiosis.
Batiha O, Swan A. | 06/30/2012 |
| Data show that Axin and Apc, but not GSK3, modulate the ligand-independent traffic of Notch. | Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila.
Muñoz-Descalzo S, Tkocz K, Balayo T, Arias AM., Free PMC Article | 05/28/2011 |
| Data show that kinesin-2, and the +TIPS EB1 and APC, are required for uniform dendrite microtubule polarity. | Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.
Mattie FJ, Stackpole MM, Stone MC, Clippard JR, Rudnick DA, Qiu Y, Tao J, Allender DL, Parmar M, Rolls MM., Free PMC Article | 04/9/2011 |
| Data underscore the essential requirement of Apc in exerting regulatory control over stem cell activity, as well as the consequences that disrupting this regulation can have on tissue homeostasis. | Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation.
Lee WC, Beebe K, Sudmeier L, Micchelli CA. | 01/21/2010 |
| APCs are not essential for asymmetric cell division or the stereotyped division axis of central brain (CB) neuroblasts, although they do affect cell cycle progression and spindle architecture. | Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth, and axon targeting?
Rusan NM, Akong K, Peifer M., Free PMC Article | 01/21/2010 |
| Apc activity is not present in vast excess, but instead is near the minimal level required for accurate graded responses to the Wingless morphogen. | Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen.
Benchabane H, Hughes EG, Takacs CM, Baird JR, Ahmed Y. | 01/21/2010 |
| findings demonstrate that Drosophila Apc homologs have an activating role in both physiological and ectopic Wingless signaling; Apc likely promotes Wingless transduction through down-regulation of Axin, a negative regulator of Wingless signaling | Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.
Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y. | 01/21/2010 |
| results show that dividing male germline stem cells use mechanisms involving centrosome function and cortically localized APC to orient mitotic spindles ensuring an asymmetric outcome in which one cell self renews and the other initiates differentiation | Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.
Yamashita YM, Jones DL, Fuller MT. | 01/21/2010 |
| Results show that although complete loss of APC1 and APC2 resulted in activation of Wingless signaling, it did not alter cell viability, cadherin-based adhesion, spindle morphology, orientation or selection of division plane, as predicted. | Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila.
McCartney BM, Price MH, Webb RL, Hayden MA, Holot LM, Zhou M, Bejsovec A, Peifer M. | 01/21/2010 |
| Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. | Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs.
Akong K, Grevengoed EE, Price MH, McCartney BM, Hayden MA, DeNofrio JC, Peifer M. | 01/21/2010 |
| APC1 and APC2 play functionally redundant roles in brain development | Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations.
Akong K, McCartney BM, Peifer M. | 01/21/2010 |
| Mutational inactivation of Drosophila E-APC causes delocalization of Armadillo (the Drosophila beta-catenin) but not DE-cadherin from adhesive plasma membranes. | A Drosophila APC tumour suppressor homologue functions in cellular adhesion.
Hamada F, Bienz M. | 01/21/2010 |
| Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. | Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
Ahmed Y, Nouri A, Wieschaus E. | 01/21/2010 |