| DNMT3a-mediated methylation of PPARgamma promote intervertebral disc degeneration by regulating the NF-kappaB pathway. | DNMT3a-mediated methylation of PPARγ promote intervertebral disc degeneration by regulating the NF-κB pathway.
Cheng P, Wei HZ, Chen HW, Wang ZQ, Mao P, Zhang HH., Free PMC Article | 02/8/2024 |
| miR-199a-3p mediates bone cancer pain through upregulation of dnmt3a expression in spinal dorsal horn neurons. | miR-199a-3p mediates bone cancer pain through upregulation of dnmt3a expression in spinal dorsal horn neurons.
Kuang J, Xu M, Xu C, Wang Y, Ni C, Wei S, Liu Z, Kong M, Zhou Q, Yao M, Ni H. | 11/2/2023 |
| POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment. | POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
Gu YH, Wang J, Lu WC, Cheng Y, Tao R, Zhang SJ, Xu T, Zhai KW, Luo SX, Xin WJ. | 10/30/2023 |
| Identification of Epigenetic Interactions between MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain. | Identification of Epigenetic Interactions between MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain.
Francés R, Mata-Garrido J, de la Fuente R, Carcelén M, Lafarga M, Berciano MT, García R, Hurlé MA, Tramullas M., Free PMC Article | 12/10/2022 |
| DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors. | DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors.
Wei J, Cheng J, Waddell NJ, Wang ZJ, Pang X, Cao Q, Liu A, Chitaman JM, Abreu K, Jasrotia RS, Duffney LJ, Zhang J, Dietz DM, Feng J, Yan Z., Free PMC Article | 01/29/2022 |
| Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity. | Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity.
Chen ZG, Wang YJ, Chen RS, Geng F, Gan CL, Wang WS, Liu X, Zhou H, He L, Hu G, Liu JG. | 06/12/2021 |
| DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats. | DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.
Zhang JJ, Jiang FZ, Zheng W, Duan Y, Jin SB, Shen F, Liang J, Li M, Sui N. | 02/20/2021 |
| our results highlight miR-369-5p mediated DNMT3A epigenetic silencing of Patched1 as a mechanism of fibroblast proliferation in cardiac fibrosis | Epigenetic aberrations of miR-369-5p and DNMT3A control Patched1 signal pathway in cardiac fibrosis.
Tao H, Dai C, Ding JF, Yang JJ, Ding XS, Xu SS, Shi KH. | 05/4/2019 |
| Peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in the injured DRG neurons via the activation of the transcription factor octamer transcription factor 1. Blocking this increase prevents nerve injury-induced methylation of the voltage-dependent potassium (Kv) channel subunit Kcna2 promoter region and rescues Kcna2 expression in the injured DRG and attenuates neuropathic pain. | DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Zhao JY, Liang L, Gu X, Li Z, Wu S, Sun L, Atianjoh FE, Feng J, Mo K, Jia S, Lutz BM, Bekker A, Nestler EJ, Tao YX., Free PMC Article | 11/17/2018 |
| DNMT3A level was upregulated and negatively correlated with miR-200b expression in fibrosis tissues and cardiac fibroblasts. Our results provide a basis for understanding the molecular mechanism by which DNMT3A and miR-200b, in combination with rapamycin, upregulates autophagic activity. | DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis.
Zhao XD, Qin RH, Yang JJ, Xu SS, Tao H, Ding XS, Shi KH. | 10/27/2018 |
| that increased dorsal horn DNMT3a contributes to bone cancer pain through silencing dorsal horn Kv1.2 expression | DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Miao XR, Fan LC, Wu S, Mao Q, Li Z, Lutz B, Xu JT, Lu Z, Tao YX., Free PMC Article | 09/8/2018 |
| These data suggest that DNMT3a is required for nerve injury-induced and MBD1-mediated epigenetic silencing of the MOR and KOR in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management. | Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons.
Sun L, Zhao JY, Gu X, Liang L, Wu S, Mo K, Feng J, Guo W, Zhang J, Bekker A, Zhao X, Nestler EJ, Tao YX., Free PMC Article | 03/10/2018 |
| The authors developed a resistant hepatocyte rat model of liver carcinogenesis showing underexpression of DNMT3a and DNMT3b during the early stages. | DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Valencia Antúnez CA, Taja Chayeb L, Rodríguez-Segura MÁ, López Álvarez GS, García-Cuéllar CM, Villa Treviño S. | 10/31/2015 |
| We have found that during acute inflammatory pain induced by the application of 10% mustard oil on the tongues of rats, levels of DNMT3a and 3b were elevated markedly | Epigenetic regulation of acute inflammatory pain.
Abzianidze E, Kvaratskhelia E, Tkemaladze T, Kankava K, Gurtskaia G, Tsagareli M. | 08/29/2015 |
| A severely altered chromatin structure during retinal degeneration coincided with an increased expression of the DNMT isozyme DNMT3a. | DNA methylation and differential gene regulation in photoreceptor cell death.
Farinelli P, Perera A, Arango-Gonzalez B, Trifunovic D, Wagner M, Carell T, Biel M, Zrenner E, Michalakis S, Paquet-Durand F, Ekström PA., Free PMC Article | 07/4/2015 |
| Topiramate prevented ethanol-induced increase in Dnmt3a expression in rate prefrontal cortex. | Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex.
Echeverry-Alzate V, Giné E, Bühler KM, Calleja-Conde J, Olmos P, Gorriti MA, Nadal R, Rodríguez de Fonseca F, López-Moreno JA., Free PMC Article | 01/24/2015 |
| DNMT3A and RASSF1A may serve as a new mechanism for cardiac fibrosis. | DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2.
Tao H, Yang JJ, Chen ZW, Xu SS, Zhou X, Zhan HY, Shi KH. | 09/27/2014 |
| Matrix has a profound effect on the regulation of SMC phenotype, which is associated with altered expression, localization of DNMTs and discrete changes DNA methylation | Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC).
Jiang JX, Aitken KJ, Sotiropoulos C, Kirwan T, Panchal T, Zhang N, Pu S, Wodak S, Tolg C, Bägli DJ., Free PMC Article | 07/5/2014 |
| Steroid hormone exposures may programme lasting differences in amygdala function by altering the expression of the epigenetic factor, DNMT3a. | Sex difference in the expression of DNA methyltransferase 3a in the rat amygdala during development.
Kolodkin MH, Auger AP., Free PMC Article | 11/12/2011 |
| Suggest that DNMT1 and DNMT3a protein overexpression may be responsible for aberrant DNA methylation of cell adhesion genes in chemically induced lung neoplasms. | Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Liu WB, Cui ZH, Ao L, Zhou ZY, Zhou YH, Yuan XY, Xiang YL, Liu JY, Cao J. | 02/26/2011 |
| results suggest that Dnmt3a expression is subject to dynamic regulation in NAc by two types of chronic emotional stimuli: chronic cocaine use and chronic social defeat stress | Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.
LaPlant Q, Vialou V, Covington HE 3rd, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ., Free PMC Article | 10/23/2010 |
| It was concluded that downregulated DNMT3a protein production during Fas-mediated hepatocyte apoptosis results from inhibition of DNMT3a gene transcription. | DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes.
Vinken M, Snykers S, Fraczek J, Decrock E, Leybaert L, Rogiers V, Vanhaecke T. | 06/14/2010 |
| in the F1 and F2 vinclozolin generation (E16) embryonic testis, but the majority returned to control-generation levels by the F3 generation. The most dramatic effects were on the germ-line-associated Dnmt3A and Dnmt3L | Transgenerational epigenetic programming of the embryonic testis transcriptome.
Anway MD, Rekow SS, Skinner MK., Free PMC Article | 01/21/2010 |