| Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc. | Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc.
Nemoto K, Masuko K, Fuse N, Kurata S. | 12/5/2023 |
| Data observed that Drl is required for the rotation of the DA1/VA1d dendritic pair. Drl is much more highly expressed by the DA1 dendrites than the adjacent VA1d dendrites. Mosaic and epistatic analyses showed that Drl specifically functions in the DA1 dendrites in which it antagonizes the Wnt5-Vang repulsion and mediates the migration of the DA1 glomerulus towards Wnt5. | Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe.
Hing H, Reger N, Snyder J, Fradkin LG., Free PMC Article | 08/1/2020 |
| Wnt5 promotes dendrite termination on the periphery of sternites through the Ryk receptor family kinase Derailed (Drl) and the Rho GTPase guanine nucleotide exchange factor Trio in C4da neurons | Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway.
Yasunaga K, Tezuka A, Ishikawa N, Dairyo Y, Togashi K, Koizumi H, Emoto K., Free PMC Article | 11/7/2015 |
| Drl promotes dorsolateral targeting of projection neuron dendrites in developing antennal lobe. | Wnt5 and drl/ryk gradients pattern the Drosophila olfactory dendritic map.
Wu Y, Helt JC, Wexler E, Petrova IM, Noordermeer JN, Fradkin LG, Hing H., Free PMC Article | 01/24/2015 |
| Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system. | Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B.
Petrova IM, Lahaye LL, Martiáñez T, de Jong AW, Malessy MJ, Verhaagen J, Noordermeer JN, Fradkin LG., Free PMC Article | 11/30/2013 |
| WNT5 interacts with doughnut and derailed to mediate muscle attachment site selection | WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster.
Lahaye LL, Wouda RR, de Jong AW, Fradkin LG, Noordermeer JN., Free PMC Article | 07/14/2012 |
| Derailed protein receptor (Drl) is localized in developing olfactory glomeruli and mediates Wnt5 signaling. | Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development.
Sakurai M, Aoki T, Yoshikawa S, Santschi LA, Saito H, Endo K, Ishikawa K, Kimura K, Ito K, Thomas JB, Hama C., Free PMC Article | 01/21/2010 |
| Src family kinases play novel roles in WNT5/Derailed-mediated signaling | Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system.
Wouda RR, Bansraj MR, de Jong AW, Noordermeer JN, Fradkin LG. | 01/21/2010 |
| Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor. Mutations in both wnt5 and drl result in a significant reduction in the number of synaptic boutons. | Derailed regulates development of the Drosophila neuromuscular junction.
Liebl FL, Wu Y, Featherstone DE, Noordermeer JN, Fradkin L, Hing H., Free PMC Article | 01/21/2010 |
| Both the Wnt4-frizzled pathway and a separate Wnt5-derailed pathway are needed for proper salivary gland migration in Drosophila embryogenesis. | Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration.
Harris KE, Beckendorf SK. | 01/21/2010 |
| WNT5 is required intrinsically within mushroom bodies neurons for proper axonal growth and probably interacts with the extrinsic DRL receptor in order to stop axonal growth. | Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development.
Grillenzoni N, Flandre A, Lasbleiz C, Dura JM. | 01/21/2010 |
| Role of the cytoplasmic domain and the kinase activity of the linotte/derailed receptor tyrosine kinase in adult brain development. | In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase, a Drosophila Ryk ortholog.
Taillebourg E, Moreau-Fauvarque C, Delaval K, Dura JM. | 01/21/2010 |
| Derailed keeps axons out of the posterior commissure by acting as a receptor for Wnt5 | Wnt-mediated axon guidance via the Drosophila Derailed receptor.
Yoshikawa S, McKinnon RD, Kokel M, Thomas JB. | 01/21/2010 |