| IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission. | IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission.
Prakash A, Fenner F, Shit B, Salminen TS, Monteith KM, Khan I, Vale PF., Free PMC Article | 07/10/2024 |
| Relish-mediated C2H2 zinc finger protein IMZF restores Drosophila immune homeostasis via inhibiting the transcription of Imd/Tak1. | Relish-mediated C2H2 zinc finger protein IMZF restores Drosophila immune homeostasis via inhibiting the transcription of Imd/Tak1.
Zhou H, Liu L, Pang Y, Xu Y, Wu J, Ma F, Jin P, Zhou X. | 06/27/2024 |
| Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2. | Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2.
Li R, Zhou H, Jia C, Jin P, Ma F., Free PMC Article | 09/26/2020 |
| Invertebrate Iridescent Virus-6 is capable of inhibiting the two Drosophila NF-kappaB signaling pathways, Imd and Toll. | IIV-6 Inhibits NF-κB Responses in Drosophila.
West C, Rus F, Chen Y, Kleino A, Gangloff M, Gammon DB, Silverman N., Free PMC Article | 07/25/2020 |
| Data suggest that the immune deficiency protein (Imd)-Nuclear Factor kappa B (NF-kappaB) pathway is central to the intestinal antibacterial response by mediating both antimicrobial peptides (AMPs) production and the maintenance of barrier integrity. | Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection.
Zhai Z, Boquete JP, Lemaitre B. | 02/2/2019 |
| Protofibrils of peptidoglycan receptors PGRP-LC and PGRP-LE seed immune deficiency protein (Imd) amyloid polymerization via Imd RIP homotypic interaction motif (RHIM), and the formation of functional Imd amyloid fibril is required for NF-kappaB signaling. | Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.
Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N., Free PMC Article | 11/11/2017 |
| the IMD/Relish signaling pathway is a central regulator of microbiota-mediated transcriptional response | Drosophila microbiota modulates host metabolic gene expression via IMD/NF-κB signaling.
Erkosar B, Defaye A, Bozonnet N, Puthier D, Royet J, Leulier F., Free PMC Article | 01/24/2015 |
| interdomain cleavage of Dredd is not required for Imd or Relish processing and is not observed during immune stimulation | The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35.
Kim CH, Paik D, Rus F, Silverman N., Free PMC Article | 10/11/2014 |
| Faf inhibits the IMD pathway by modulating the state of Imd ubiquitination and/or stability. | fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila.
Yagi Y, Lim YM, Tsuda L, Nishida Y. | 08/9/2014 |
| Using the Drosophila model and mutations in the Toll and Imd pathways, authors showed that neither pathway is required for expression of the dengue virus-blocking phenotype in the Drosophila host. | The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference.
Rancès E, Johnson TK, Popovici J, Iturbe-Ormaetxe I, Zakir T, Warr CG, O'Neill SL., Free PMC Article | 11/30/2013 |
| Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria. | Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila.
Nelson B, Freisinger T, Ishii K, Okado K, Shinzawa N, Fukumoto S, Kanuka H. | 07/27/2013 |
| Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling. | Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells.
Ragab A, Buechling T, Gesellchen V, Spirohn K, Boettcher AL, Boutros M., Free PMC Article | 05/21/2011 |
| We show that an imd-regulated immune response is important for fighting F. novicida infections | Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune response.
Moule MG, Monack DM, Schneider DS., Free PMC Article | 12/4/2010 |
| members of the imd pathway might be targets of entomopathogenic bacteria through synthesis of antimicrobial peptides induced by Xenorhabdus nematophila as well as Photorhabdus luminescens | Imd pathway is involved in the interaction of Drosophila melanogaster with the entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus luminescens.
Aymeric JL, Givaudan A, Duvic B. | 09/6/2010 |
| the death protein dFADD was isolated as a molecule that associates with IMD | The Drosophila immune defense against gram-negative infection requires the death protein dFADD.
Naitza S, Rossé C, Kappler C, Georgel P, Belvin M, Gubb D, Camonis J, Hoffmann JA, Reichhart JM. | 01/21/2010 |
| Gram-negative diaminopimelic acid-type peptidoglycan is the most potent inducer of the Imd pathway and that the Toll pathway is predominantly activated by Gram-positive lysine-type peptidoglycan. | The Drosophila immune system detects bacteria through specific peptidoglycan recognition.
Leulier F, Parquet C, Pili-Floury S, Ryu JH, Caroff M, Lee WJ, Mengin-Lecreulx D, Lemaitre B. | 01/21/2010 |
| in larvae, the imd-mediated antibacterial defense is activated by peptidoglycan-recognition protein (PGRP)-LE | Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae.
Takehana A, Katsuyama T, Yano T, Oshima Y, Takada H, Aigaki T, Kurata S., Free PMC Article | 01/21/2010 |
| The Toll and Imd pathways are the major regulators of the immune response in Drosophila | The Toll and Imd pathways are the major regulators of the immune response in Drosophila.
De Gregorio E, Spellman PT, Tzou P, Rubin GM, Lemaitre B., Free PMC Article | 01/21/2010 |