| Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease. | Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease.
Nam J, Richie CT, Harvey BK, Voutilainen MH., Free PMC Article | 08/16/2024 |
| Cerebral dopamine neurotrophic factor reduces alpha-synuclein aggregation and propagation and alleviates behavioral alterations in vivo. | Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.
Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M., Free PMC Article | 02/12/2022 |
| Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by microRNAs. | Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by microRNAs.
Konovalova J, Gerasymchuk D, Arroyo SN, Kluske S, Mastroianni F, Pereyra AV, Domanskyi A., Free PMC Article | 10/30/2021 |
| Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. | Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon.
Jaumotte JD, Saarma M, Zigmond MJ., Free PMC Article | 09/11/2021 |
| Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential. | Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential.
Eremin DV, Ilchibaeva TV, Tsybko AS. | 08/7/2021 |
| Cerebral dopamine neurotrophic factor gene expression was significantly reduced in stroke patients relative to control subjects. | Decreased Expression of Cerebral Dopamine Neurotrophic Factor in Platelets of Stroke Patients.
Joshi H, McIntyre WB, Kooner S, Rathbone M, Gabriele S, Gabriele J, Baranowski D, Frey BN, Mishra RK. | 02/15/2020 |
| Polymorphisms in CDN,F identified in a Han Chinese population, were associated with increased susceptibility to schizophrenia. | Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population.
Yang Y, Yu H, Li W, Liu B, Zhang H, Ding S, Lu Y, Jiang T, Lv L., Free PMC Article | 09/29/2018 |
| In various animal models of Parkinson Disease, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, euroinflammation, and apoptosis. | Cerebral Dopamine Neurotrophic Factor: A Potential Therapeutic Agent for Parkinson's Disease.
Tang T, Li Y, Jiao Q, Du X, Jiang H., Free PMC Article | 06/30/2018 |
| The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion). | Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression.
Wang L, Wang Z, Zhu R, Bi J, Feng X, Liu W, Wu J, Zhang H, Wu H, Kong W, Yu B, Yu X., Free PMC Article | 09/16/2017 |
| Results suggest that CDNF treatment selectively enhances long-term memory consolidation | Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.
Kemppainen S, Lindholm P, Galli E, Lahtinen HM, Koivisto H, Hämäläinen E, Saarma M, Tanila H. | 04/2/2016 |
| showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers | The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers.
Latge C, Cabral KM, de Oliveira GA, Raymundo DP, Freitas JA, Johanson L, Romão LF, Palhano FL, Herrmann T, Almeida MS, Foguel D., Free PMC Article | 12/12/2015 |
| Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease. | Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra.
Nadella R, Voutilainen MH, Saarma M, Gonzalez-Barrios JA, Leon-Chavez BA, Jiménez JM, Jiménez SH, Escobedo L, Martinez-Fong D., Free PMC Article | 11/21/2015 |
| Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found. | Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease.
Choi JM, Hong JH, Chae MJ, Ngyuen PH, Kang HS, Ma HI, Kim YJ. | 09/3/2011 |
| structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain | The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.
Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A. | 01/21/2010 |
| Study suggests that there is no association between variants in the CDNF gene and cocaine dependence. | Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence.
Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, O'Brien CP, Kampman KM, Oslin DW, Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, O'Brien CP, Kampman KM, Oslin DW., Free PMC Articles: PMC2680755, PMC2680755 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence.
Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, O'Brien CP, Kampman KM, Oslin DW, Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, O'Brien CP, Kampman KM, Oslin DW., Free PMC Articles: PMC2680755, PMC2680755 | 05/17/2009 |
| expressed in several tissues; might be beneficial for the treatment of Parkinson's disease | Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.
Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M. | 01/21/2010 |