| Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila. | Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.
Han Y, Zhuang N, Wang T. | 01/29/2022 |
| Our findings identify a novel PTEN/dPLCXD pathway that controls PtdIns(4,5)P2 levels on endosomes. They also point to a potential new strategy for the treatment of Lowe syndrome. | PTEN reduces endosomal PtdIns(4,5)P(2) in a phosphatase-independent manner via a PLC pathway.
Mondin VE, Ben El Kadhi K, Cauvin C, Jackson-Crawford A, Bélanger E, Decelle B, Salomon R, Lowe M, Echard A, Carréno S., Free PMC Article | 05/16/2020 |
| Here we show that PTEN mutation impacts aPKC and Lgl protein levels also in Drosophila. Moreover, we demonstrate that PI3K activation is not sufficient to trigger tumourigenesis, while aPKC promotes hyperplastic growth of the neuroepithelium and a noticeable expansion of the type II neuroblasts. | Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila.
Paglia S, Sollazzo M, Di Giacomo S, de Biase D, Pession A, Grifoni D., Free PMC Article | 08/18/2018 |
| Ectopic expression of dPTEN (a phosphatase and tensin homologue) in the fat body prolongs fruit fly life. | Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes.
Proshkina EN, Shaposhnikov MV, Sadritdinova AF, Kudryavtseva AV, Moskalev AA. | 12/17/2016 |
| PTEN deficient cells proliferate under conditions of nutrient restriction. | Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues.
Nowak K, Seisenbacher G, Hafen E, Stocker H., Free PMC Article | 04/16/2016 |
| loss of the tumor suppressor PTEN disrupts cell rearrangements by preventing the lengthening of newly formed junctions that become unstable and keep on rearranging | PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue.
Bardet PL, Guirao B, Paoletti C, Serman F, Léopold V, Bosveld F, Goya Y, Mirouse V, Graner F, Bellaïche Y. | 08/31/2013 |
| study demonstrates that in the Drosophila lymph gland the tumor suppressors TSC and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway | Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors.
Dragojlovic-Munther M, Martinez-Agosto JA., Free PMC Article | 12/8/2012 |
| Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. | Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Song Y, Ori-McKenney KM, Zheng Y, Han C, Jan LY, Jan YN., Free PMC Article | 09/29/2012 |
| Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells. | Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines.
Justiniano SE, Mathew A, Mitra S, Manivannan SN, Simcox A., Free PMC Article | 06/30/2012 |
| A mutation in the pleckstrin homology (PH) domain of Akt that reduces its affinity for PIP3 sufficed to rescue the lethality of flies devoid of PTEN activity. | Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.
Stocker H, Andjelkovic M, Oldham S, Laffargue M, Wymann MP, Hemmings BA, Hafen E. | 01/21/2010 |
| dPTEN3 is the predominant spliced form that participates in PI(3,4,5)P(3)-mediated signaling pathways | Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN.
Maehama T, Kosaka N, Okahara F, Takeuchi K, Umeda M, Dixon JE, Kanaho Y. | 01/21/2010 |
| PTEN genes participate in mechanisms that regulate organ and organism size in animals (REVIEW) | The tuberous sclerosis complex (TSC) pathway and mechanism of size control.
Potter CJ, Pedraza LG, Huang H, Xu T. | 01/21/2010 |
| Pten is indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis. | The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A., Free PMC Article | 01/21/2010 |
| Our study confirms the redox regulation of PTEN through disulfide bond formation with the hTrx-1 in Drosophila and suggests conserved mechanisms for thioredoxins and their interactions with the PI3-kinase signaling pathway in humans and fruit flies. | Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster.
Song Z, Saghafi N, Gokhale V, Brabant M, Meuillet EJ., Free PMC Article | 01/21/2010 |
| Data show that DJ-1 is a key negative regulator of PTEN that may be a useful prognostic marker for cancer. | DJ-1, a novel regulator of the tumor suppressor PTEN.
Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, Binari RC, Manoukian AS, Bray MR, Liu FF, Tsao MS, Mak TW. | 01/21/2010 |