| Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila. | Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila.
Li Y, Jiang Z, Xu Y, Yan J, Wu Q, Huang S, Wang L, Xie Y, Wu X, Wang Y, Li Y, Fan X, Li F, Yuan W., Free PMC Article | 07/18/2024 |
| Structure and function of Pygo in organ development dependent and independent Wnt signalling. | Structure and function of Pygo in organ development dependent and independent Wnt signalling.
Shi Y, Wu X, Zhu S, Huang H, Zhuang J, Yuan H, Yuan W, Zhu P. | 06/5/2021 |
| The authors use a proteomics approach to discover the Chip/LDB-SSDP (ChiLS) complex as the ligand specifically binding to NPF motif of Pygo proteins. | An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.
Fiedler M, Graeb M, Mieszczanek J, Rutherford TJ, Johnson CM, Bienz M., Free PMC Article | 06/11/2016 |
| results are consistent with the idea that pygo functions independently of canonical Wnt signaling in the differentiation of the adult interchamber cardiac valves | The role of pygopus in the differentiation of intracardiac valves in Drosophila.
Tang M, Yuan W, Bodmer R, Wu X, Ocorr K., Free PMC Article | 09/27/2014 |
| humanized fly Pygo derepresses Notch targets, implying an inherent Notch-related function of classical Pygo orthologs, disabled in fly Pygo, which thus appears dedicated to Wnt signaling. | Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2.
Miller TC, Mieszczanek J, Sánchez-Barrena MJ, Rutherford TJ, Fiedler M, Bienz M., Free PMC Article | 09/20/2014 |
| Double knockdown of pygo and Ca2+/calmodulin-dependent protein kinase II caused additional arrhythmia compared with pygo knockdown alone, suggesting that some of the effects of pygo are mediated by Ca2+ signaling. | Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.
Tang M, Yuan W, Fan X, Liu M, Bodmer R, Ocorr K, Wu X., Free PMC Article | 05/17/2014 |
| the PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 | The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.
Kessler R, Hausmann G, Basler K. | 01/21/2010 |
| Pygo predisposes Drosophila T cell factor target genes for rapid Wingless-induced transcription, or it protects them against premature shut-down | A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.
Mieszczanek J, de la Roche M, Bienz M., Free PMC Article | 01/21/2010 |
| Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me). | Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.
Fiedler M, Sánchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P, Bienz M., Free PMC Article | 01/21/2010 |
| Pygopus promotes Wnt target gene transcription by recruiting the mediator complex through interactions with Med12 and Med13. | Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.
Carrera I, Janody F, Leeds N, Duveau F, Treisman JE., Free PMC Article | 01/21/2010 |
| nuclear PHD-finger protein required for Wingless signaling in Drosophila. | Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila.
Parker DS, Jemison J, Cadigan KM. | 01/21/2010 |
| Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. | Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin.
Hoffmans R, Städeli R, Basler K. | 01/21/2010 |
| identifed conserved residues within Pygopus that are required for binding to Legless in vitro and for their activity in development | Pygopus residues required for its binding to Legless are critical for transcription and development.
Townsley FM, Thompson B, Bienz M. | 01/21/2010 |
| Pygo is an essential component in the Wg/Wnt signal transduction pathway and is likely to act as a transcription co-activator required for the nuclear function of Arm/beta-catenin | pygopus Encodes a nuclear protein essential for wingless/Wnt signaling.
Belenkaya TY, Han C, Standley HJ, Lin X, Houston DW, Heasman J, Lin X. | 01/21/2010 |
| Pygo and Lgs function in targeting Armadillo/beta-catenin to the nucleus, thus ensuring its availability to TCF during Wnt signalling. | Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.
Townsley FM, Cliffe A, Bienz M. | 01/21/2010 |
| nuclear component of the Wnt signalling pathway; presence of a PHD domain implicates Pygo protein in a chromatin-related function | A new nuclear component of the Wnt signalling pathway.
Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M. | 01/21/2010 |