| Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin. | Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin.
Gammons MV, Renko M, Flack JE, Mieszczanek J, Bienz M., Free PMC Article | 02/20/2021 |
| Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. | Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.
Schaefer KN, Pronobis MI, Williams CE, Zhang S, Bauer L, Goldfarb D, Yan F, Major MB, Peifer M., Free PMC Article | 02/6/2021 |
| Iduna-mediated regulation of Axin proteolysis is essential for tissue homeostasis in the Drosophila midgut | Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila.
Gultekin Y, Steller H., Free PMC Article | 01/11/2020 |
| Novel requirement for APC in Axin regulation through phosphorylation both prevents signaling in the Wnt-off state and promotes signaling immediately following Wnt stimulation. | Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.
Tacchelly-Benites O, Wang Z, Yang E, Benchabane H, Tian A, Randall MP, Ahmed Y., Free PMC Article | 07/21/2018 |
| We conclude that even in the unstimulated state, a pool of Axin forms membrane-proximal puncta that are dependent on Apc, and that membrane association regulates both Axin levels and Axin's role in the rapid activation of signaling that follows Wnt exposure. | Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.
Wang Z, Tacchelly-Benites O, Yang E, Ahmed Y., Free PMC Article | 05/13/2017 |
| The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells. | Wnt pathway activation by ADP-ribosylation.
Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y., Free PMC Article | 09/10/2016 |
| Daxin physically interacts with DTNKS, and its protein levels are elevated in the absence of DTNKS in the eye discs. | The Drosophila tankyrase regulates Wg signaling depending on the concentration of Daxin.
Feng Y, Li X, Ray L, Song H, Qu J, Lin S, Lin X., Free PMC Article | 01/10/2015 |
| co-expression experiments reveal that APC displaces Dishevelled from Axin assemblies, promoting degradasome over signalosome formation in the absence of Wnts | The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled.
Mendoza-Topaz C, Mieszczanek J, Bienz M., Free PMC Article | 06/29/2013 |
| Data show that Axin and Apc, but not GSK3, modulate the ligand-independent traffic of Notch. | Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila.
Muñoz-Descalzo S, Tkocz K, Balayo T, Arias AM., Free PMC Article | 05/28/2011 |
| This result implies that Dishevelled has the potential to act as a "natural" dominant-negative, binding to the polymerization interface of Axin's DIX domain to interfere with its self-assembly | Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin.
Fiedler M, Mendoza-Topaz C, Rutherford TJ, Mieszczanek J, Bienz M., Free PMC Article | 03/26/2011 |
| differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin. | In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin.
Kremer SA, Erdeniz N, Peterson-Nedry W, Swanson EA, Wehrli M., Free PMC Article | 01/21/2010 |
| membrane-tethered Axin is sufficient for the proper transduction of Wg signal in the patterning of the Drosophila embryo | Membrane bound axin is sufficient for Wingless signaling in Drosophila embryos.
Tolwinski NS., Free PMC Article | 01/21/2010 |
| Axin complex is assembled through cooperative tripartite interactions among the binding partners, making the assembly of functional complexes surprisingly robust. | Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.
Peterson-Nedry W, Erdeniz N, Kremer S, Yu J, Baig-Lewis S, Wehrli M., Free PMC Article | 01/21/2010 |
| mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin | A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.
Penton A, Wodarz A, Nusse R., Free PMC Article | 01/21/2010 |
| Axin synergizes with Notch to regulate the activity of armadillo in Drosophila. | Notch synergizes with axin to regulate the activity of armadillo in Drosophila.
Hayward P, Balayo T, Martinez Arias A. | 01/21/2010 |