| we show that during the development of epithelial cells in the imaginal discs, the G2/M transition, and hence cell proliferation, is controlled by Emc via Da. In eukaryotic cells, the main activator of this transition is the Cdc25 phosphatase, string | The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase string.
Andrade-Zapata I, Baonza A., Free PMC Article | 11/29/2014 |
| The degradation rate of String protein gradually increases during the late syncytial cycles in a manner dependent on the nuclear-to-cytoplasmic ratio and on the DNA replication checkpoints. | Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program.
Di Talia S, She R, Blythe SA, Lu X, Zhang QF, Wieschaus EF., Free PMC Article | 08/10/2013 |
| Premature removal of cdc25 transcripts by RNAi did not affect progression to the midblastula transition. | Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling.
Farrell JA, O'Farrell PH., Free PMC Article | 08/10/2013 |
| findings suggest that high Cdc25 and Cdk1 contribute to the speed of the rapid, pre-midblastula transition (MBT) S phases and that down-regulation of these activities plays a broader role in MBT-associated changes than was previously suspected | Embryonic onset of late replication requires Cdc25 down-regulation.
Farrell JA, Shermoen AW, Yuan K, O'Farrell PH., Free PMC Article | 05/19/2012 |
| String (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis. | String (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis.
Inaba M, Yuan H, Yamashita YM., Free PMC Article | 01/7/2012 |
| SIN3 and STG are linked in a genetic pathway that affects cell cycle progression in a developing tissue | Regulation of cell proliferation and wing development by Drosophila SIN3 and String.
Swaminathan A, Pile LA. | 05/10/2010 |
| Thereby, we show that abdominal histoblasts, which grow while in G2 arrest during larval stages, enter a proliferative stage in the pupal period that is initiated by ecdysone-dependent string/Cdc25 phosphatase transcription. | Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts.
Ninov N, Manjón C, Martín-Blanco E., Free PMC Article | 01/21/2010 |
| double-stranded RNA-mediated depletion of dPrp38 or dMFAP1 causes cells to arrest in G(2)/M, and this is paralleled by a reduction in mRNA levels of the mitotic phosphatase string/cdc25. | Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression.
Andersen DS, Tapon N., Free PMC Article | 01/21/2010 |
| String and dappled were identified as being important for the proper formation of adult external sensory (ES) organs. | A mis-expression study of factors affecting Drosophila PNS cell identity.
O'Farrell F, Kylsten P. | 01/21/2010 |
| EYA and SO may influence cell proliferation through transcriptional regulation of stg. | Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent.
Jemc J, Rebay I., Free PMC Article | 01/21/2010 |
| string(cdc25) and cyclin E control patterned histone expression at different stages of Drosophila embryonic development. | string(cdc25) and cyclin E are required for patterned histone expression at different stages of Drosophila embryonic development.
Lanzotti DJ, Kupsco JM, Marzluff WF, Duronio RJ. | 01/21/2010 |
| Induction of stg rescues the neuroblast proliferation defect in trol mutant animals. | Induction of string rescues the neuroblast proliferation defect in trol mutant animals.
Park Y, Ng C, Datta S. | 01/21/2010 |
| Pointed, an activator, and Tramtrack69, a repressor, directly regulate the transcription of string and thereby cell proliferation | Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis.
Baonza A, Murawsky CM, Travers AA, Freeman M. | 01/21/2010 |