| Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma. | Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma.
Zheng E, Cai Z, Li W, Ni C, Fang Q., Free PMC Article | 09/3/2022 |
| TET2-BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter. | TET2-BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter.
Shang Y, Jiang T, Ran L, Hu W, Wu Y, Ye J, Peng Z, Chen L, Wang R., Free PMC Article | 07/30/2022 |
| ASCL2 Affects the Efficacy of Immunotherapy in Colon Adenocarcinoma Based on Single-Cell RNA Sequencing Analysis. | ASCL2 Affects the Efficacy of Immunotherapy in Colon Adenocarcinoma Based on Single-Cell RNA Sequencing Analysis.
Wu L, Sun S, Qu F, Liu X, Sun M, Pan Y, Zheng Y, Su G., Free PMC Article | 07/16/2022 |
| Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer. | Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer.
Yang Q, Huang G, Li L, Li E, Xu L., Free PMC Article | 10/16/2021 |
| ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. | ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development.
Varberg KM, Iqbal K, Muto M, Simon ME, Scott RL, Kozai K, Choudhury RH, Aplin JD, Biswell R, Gibson M, Okae H, Arima T, Vivian JL, Grundberg E, Soares MJ., Free PMC Article | 08/21/2021 |
| High ASCL2 expression is associated with colon cancer. | WiNTRLINC1/ASCL2/c-Myc Axis Characteristics of Colon Cancer with Differentiated Histology at Young Onset and Essential for Cell Viability.
Yokota K, Tanaka Y, Harada H, Kaida T, Nakamoto S, Soeno T, Fujiyama Y, Yokota M, Kojo K, Miura H, Yamanashi T, Sato T, Nakamura T, Watanabe M, Yamashita K. | 04/18/2020 |
| Ascl2 negatively modulates pathogenic Th17cell differentiation via promoting IL-10 production, and alleviates intestinal inflammation. | Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease.
Yi Q, Wang J, Song Y, Guo Z, Lei S, Yang X, Li L, Gao C, Zhou Z. | 11/9/2019 |
| R-spondin1/Wnt activated Ascl2 expression dose-dependently in the CD133(+)CD44(+) colorectal cancer population. | R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells.
Ye J, Liu S, Shang Y, Chen H, Wang R., Free PMC Article | 11/2/2019 |
| Study uncovers that SMYD3 controls Wnt induced activation of ASCL2 in cancer stem cells (CSCs) by regulating H3K4me3 status. These findings suggest that Wnt signals through a SMYD3-mediated epigenetic switch to promote ASCL2 expression and CSC maintenance in human gastric carcinoma (GC). Overexpression of SMYD3 and ASCL2 are associated with poor prognosis in GC patients. | SMYD3 controls a Wnt-responsive epigenetic switch for ASCL2 activation and cancer stem cell maintenance.
Wang T, Wu H, Liu S, Lei Z, Qin Z, Wen L, Liu K, Wang X, Guo Y, Liu Q, Liu L, Wang J, Lin L, Mao C, Zhu X, Xiao H, Bian X, Chen D, Xu C, Wang B. | 08/10/2019 |
| High ASCL2 expression is associated with Drug Resistance in Colorectal Cancer. | Comprehensive Genetic Search to Clarify the Molecular Mechanism of Drug Resistance Identifies ASCL2-LEF1/TSPAN8 Axis in Colorectal Cancer.
Tanaka T, Kojima K, Yokota K, Tanaka Y, Ooizumi Y, Ishii S, Nishizawa N, Yokoi K, Ushiku H, Kikuchi M, Kojo K, Minatani N, Katoh H, Sato T, Nakamura T, Sawanobori M, Watanabe M, Yamashita K. | 08/10/2019 |
| SNP rs1335532 associated with multiple sclerosis is located in active CD58 enhancer region and creates a strong functional Ascl2-binding site. | Protective C allele of the single-nucleotide polymorphism rs1335532 is associated with strong binding of Ascl2 transcription factor and elevated CD58 expression in B-cells.
Mitkin NA, Muratova AM, Korneev KV, Pavshintsev VV, Rumyantsev KA, Vagida MS, Uvarova AN, Afanasyeva MA, Schwartz AM, Kuprash DV. | 07/6/2019 |
| ASCL2 increase by L1 overexpression enhanced its expression, cell motility, tumorigenesis and metastasis, similar to L1 overexpression. Its suppression in cells expressing L1 blocked these tumorigenic properties. In CRC tissue, ASCL2 was detected in the nuclei of cells at invasive areas of the tumor that also expressed L1. Results suggest that increased ASCL2 expression is a critical step in L1-mediated CRC progression. | The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
Basu S, Gavert N, Brabletz T, Ben-Ze'ev A. | 06/15/2019 |
| ASCL2 was able to downregulate the expression level of miR223, contribute to Epithelial-Mesenchymal Transition and promote gastric tumor metastasis. | ASCL2 expression contributes to gastric tumor migration and invasion by downregulating miR223 and inducing EMT.
Zuo Q, Wang J, Chen C, Zhang Y, Feng DX, Zhao R, Chen T., Free PMC Article | 01/12/2019 |
| We address this paradox using basic helix-loop-helix (bHLH) transcription factors ASCL1, ASCL2, and MYOD1, crucial mediators of lineage specification..Although the ASCL factors and MYOD1 have some distinct DNA motif preference, it is not sufficient to explain the extent of the differential binding. All three factors can bind inaccessible chromatin and induce changes in chromatin accessibility and H3K27ac | Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors.
Casey BH, Kollipara RK, Pozo K, Johnson JE., Free PMC Article | 10/6/2018 |
| this study shows that Ascl2 level was higher in peripheral blood mononuclear cells from Sjogren's syndrome patients compared with those from healthy controls | Achaete-scute complex homologue 2 accelerates the development of Sjögren's syndrome-like disease in the NOD/ShiLtJ mouse.
Kim SM, Kwon JE, Park JS, Seo HB, Jung KA, Moon YM, Lee J, Kwok SK, Cho ML, Park SH. | 07/14/2018 |
| A novel HIF-1alpha/Ascl2/miR-200b regulatory feedback circuit in modulating EMT-MET plasticity of CRC cells, which could serve as a possible therapeutic target. | HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
Shang Y, Chen H, Ye J, Wei X, Liu S, Wang R. | 11/11/2017 |
| WiNTRLINC1 interacts with TCF4/beta-catenin to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2. | A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate.
Giakountis A, Moulos P, Zarkou V, Oikonomou C, Harokopos V, Hatzigeorgiou AG, Reczko M, Hatzis P. | 10/14/2017 |
| Ascl2 over-expression is associated with colorectal neoplasms. | Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation.
Shang Y, Pan Q, Chen L, Ye J, Zhong X, Li X, Meng L, Guo J, Tian Y, He Y, Chen W, Peng Z, Wang R., Free PMC Article | 08/27/2016 |
| expression of ASCL2 may identify an aggressive subgroup in lung squamous cell carcinoma | Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma.
Hu XG, Chen L, Wang QL, Zhao XL, Tan J, Cui YH, Liu XD, Zhang X, Bian XW. | 08/6/2016 |
| SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis. | SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
Zhou ZH, Rao J, Yang J, Wu F, Tan J, Xu SL, Ding Y, Zhan N, Hu XG, Cui YH, Zhang X, Dong W, Liu XD, Bian XW. | 10/10/2015 |
| SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. | SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.
Rönsch K, Jägle S, Rose K, Seidl M, Baumgartner F, Freihen V, Yousaf A, Metzger E, Lassmann S, Schüle R, Zeiser R, Michoel T, Hecht A., Free PMC Article | 09/26/2015 |
| ASCL2 gene expression is regulated by miR-200a/b/c, miR-141 and miR429 levels in colon cancer. | MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells.
Tian Y, Pan Q, Shang Y, Zhu R, Ye J, Liu Y, Zhong X, Li S, He Y, Chen L, Zhao J, Chen W, Peng Z, Wang R., Free PMC Article | 04/18/2015 |
| Ascl2 directly initiates follicular T-helper cell development | Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.
Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C., Free PMC Article | 04/26/2014 |
| These results suggest that ASCL2 might play an important role in gastric tumor growth and chemoresistance. | Aberrant upregulation of ASCL2 by promoter demethylation promotes the growth and resistance to 5-fluorouracil of gastric cancer cells.
Kwon OH, Park JL, Baek SJ, Noh SM, Song KS, Kim SY, Kim YS., Free PMC Article | 04/27/2013 |
| Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells | Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.
Zhu R, Yang Y, Tian Y, Bai J, Zhang X, Li X, Peng Z, He Y, Chen L, Pan Q, Fang D, Chen W, Qian C, Bian X, Wang R., Free PMC Article | 09/1/2012 |