| Crumbs complex-directed apical membrane dynamics in epithelial cell ingression. | Crumbs complex-directed apical membrane dynamics in epithelial cell ingression.
Simões S, Lerchbaumer G, Pellikka M, Giannatou P, Lam T, Kim D, Yu J, Ter Stal D, Al Kakouni K, Fernandez-Gonzalez R, Tepass U., Free PMC Article | 05/28/2022 |
| Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye. | Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
Pojer JM, Saiful Hilmi AJ, Kondo S, Harvey KF., Free PMC Article | 10/30/2021 |
| Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila. | Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
Jung J, Yeom E, Choi KW., Free PMC Article | 04/13/2021 |
| Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay. | Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
Arefin B, Parvin F, Bahrampour S, Stadler CB, Thor S. | 09/26/2020 |
| Crumbs as an essential hub required to maintain the organization of the apical membrane and the physiological activity of the larval salivary gland. | Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P(2) in Drosophila.
Lattner J, Leng W, Knust E, Brankatschk M, Flores-Benitez D., Free PMC Article | 05/16/2020 |
| Results show that Crb redistributes to the subapical region during pupal wing development and is not required for apical/basal and planar polarities of the pupal wing epithelium, but participates in prehair formation and hexagonal packing during morphogenesis. Crb is required during wing morphogenesis for the integrity and stability of adherens junctions and circumferential actomyosin belt. | Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.
Salis P, Payre F, Valenti P, Bazellieres E, Le Bivic A, Mottola G., Free PMC Article | 07/20/2019 |
| Consistent with the role of Crb in apical membrane growth, RNAi-mediated knockdown of Crb results in decreased apical surface growth of tracheal cells and impaired axial elongation of the dorsal trunk. We conclude that Apn is a novel regulator of tracheal tube expansion in larval tracheae, the function of which is mediated by Crb. | The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.
Skouloudaki K, Papadopoulos DK, Tomancak P, Knust E., Free PMC Article | 03/16/2019 |
| Suggest a model in which Src42A would sense the inherent anisotropic mechanical tension of the tracheal tube and translate it into a polarised Crumbs accumulation, which may promote a bias towards longitudinal membrane expansion, orienting cell elongation and, as a consequence, longitudinal growth at the tissue level. | Anisotropic Crb accumulation, modulated by Src42A, is coupled to polarised epithelial tube growth in Drosophila.
Olivares-Castiñeira I, Llimargas M., Free PMC Article | 03/2/2019 |
| Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues, is reported. | A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues.
Parsons LM, Grzeschik NA, Amaratunga K, Burke P, Quinn LM, Richardson HE., Free PMC Article | 06/30/2018 |
| Results demonstrate that the apical membrane localization of Crumbs is promoted by Dlg5. | Dlg5 maintains apical polarity by promoting membrane localization of Crumbs during Drosophila oogenesis.
Luo J, Wang H, Kang D, Guo X, Wan P, Wang D, Chen J., Free PMC Article | 05/26/2018 |
| Several Crb mutant proteins accumulated abnormally in the rhabdomere and affected rhodopsin trafficking, suggesting that abnormal rhodopsin physiology contributes to Crb/CRB1-associated retinal degeneration. | Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.
Pellikka M, Tepass U. | 03/31/2018 |
| The regulation of Crumbs by Neur is not strictly essential, it contributes to epithelium remodeling in the posterior midgut and thereby facilitates the trans-epithelial migration of the primordial germ cells in early embryos. | Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms.
Perez-Mockus G, Roca V, Mazouni K, Schweisguth F., Free PMC Article | 10/7/2017 |
| The data provide a molecular basis to explain how the apical determinant Crb can regulate homeostasis of epithelial cells by stabilising Notch at the apical membrane, thereby finetuning Notch pathway activity. | Drosophila Crumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis.
Nemetschke L, Knust E. | 09/16/2017 |
| Study proposes that the interplay of Crb expression in the DV boundary and ubiquitin-dependent Crb downregulation by Ebi provides a mechanism for the maintenance of Notch signaling during wing development. | Ebi modulates wing growth by ubiquitin-dependent downregulation of Crumbs in Drosophila.
Nguyen MB, Vuong LT, Choi KW. | 09/9/2017 |
| we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded | EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation.
Olivares-Castiñeira I, Llimargas M., Free PMC Article | 08/5/2017 |
| Data presented here point to a critical role of Crumbs in regulating actomyosin dynamics, cell junctions and morphogenesis. | Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila.
Flores-Benitez D, Knust E., Free PMC Article | 10/22/2016 |
| The adaptor protein 2 (AP-2) complex binds to a motif in the cytoplasmic tail of Crumbs that overlaps with the binding site of Stardust, a protein known to stabilize Crumbs on the surface. | AP-2-complex-mediated endocytosis of Drosophila Crumbs regulates polarity by antagonizing Stardust.
Lin YH, Currinn H, Pocha SM, Rothnie A, Wassmer T, Knust E. | 09/24/2016 |
| The Crumbs:Par-6 crystal structure reveals specific PDZ-peptide contacts that contribute to its higher affinity. | Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.
Whitney DS, Peterson FC, Kittell AW, Egner JM, Prehoda KE, Volkman BF., Free PMC Article | 08/20/2016 |
| regulation of Crumbs alternative splicing by the Obelus helicase modulates epithelial polarity during development | The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity.
Vichas A, Laurie MT, Zallen JA., Free PMC Article | 04/9/2016 |
| RNKR motif in Crumbs mediates interaction with Sar1 and contributes to efficient ER export. | A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export.
Kumichel A, Kapp K, Knust E., Free PMC Article | 02/6/2016 |
| A novel Crb-Galla-Xpd complex and its function for proper chromosome segregation. | Crumbs interacts with Xpd for nuclear division control in Drosophila.
Yeom E, Hong ST, Choi KW. | 08/29/2015 |
| phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin | Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin.
Wei Z, Li Y, Ye F, Zhang M., Free PMC Article | 07/25/2015 |
| Early endocytosis maintains normal steady-state levels of Crumbs, which recruits apical phosphorylated (active) Moesin, which in turn regulates seamless tube shape through modulation of cortical actin filaments. | Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin.
Schottenfeld-Roames J, Rosa JB, Ghabrial AS., Free PMC Article | 04/4/2015 |
| Crumbs localisation in the principal cells of the hindgut depends on Stardust. In contrast, localisation of Crumbs in the boundary cells does not require Stardust and is independent of its PDZ domain- and FERM-domain binding motifs. | Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust.
Kumichel A, Knust E., Free PMC Article | 01/24/2015 |
| As well as repressing Yki by recruiting Ex to the apical membrane, Crb promotes phosphorylation-dependent ubiquitin-mediated degradation of Ex. | Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.
Ribeiro P, Holder M, Frith D, Snijders AP, Tapon N., Free PMC Article | 07/12/2014 |