| Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells. | Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells.
Wozny MR, Nelea V, Siddiqui IFS, Wanga S, de Waard V, Strauss M, Reinhardt DP., Free PMC Article | 07/11/2024 |
| Presence of microfibril associated glycoprotein 4 and type V collagen and the possible absence of fibrillin-1 in bead-like structures in elastofibroma. | Presence of microfibril associated glycoprotein 4 and type V collagen and the possible absence of fibrillin-1 in bead-like structures in elastofibroma.
Nishida H, Sasaki T, Taga Y, Murasawa Y, Simizu S, Matsushita S, Isogai Z, Hattori S, Daa T, Nagamine N, Sekine A, Fujiwara S. | 01/3/2024 |
| Tumor-suppressive role of microfibrillar associated protein 4 and its clinical significance as prognostic factor and diagnostic biomarker in hepatocellular carcinoma. | Tumor-suppressive role of microfibrillar associated protein 4 and its clinical significance as prognostic factor and diagnostic biomarker in hepatocellular carcinoma.
Li J, Wang J, Liu Z, Guo H, Wei X, Wei Q, Zheng S, Xu X. | 01/21/2023 |
| Microfibrillar-associated protein 4 in health and disease. | Microfibrillar-associated protein 4 in health and disease.
Kanaan R, Medlej-Hashim M, Jounblat R, Pilecki B, Sorensen GL. | 09/17/2022 |
| Exploration of the Important Role of Microfibril-Associated Protein 4 Gene in Oral Squamous Cell Carcinoma. | Exploration of the Important Role of Microfibril-Associated Protein 4 Gene in Oral Squamous Cell Carcinoma.
Han Y, Xia K, Su T., Free PMC Article | 12/11/2021 |
| Relationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney Disease. | Relationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney Disease.
Kara SP, Özkan G, Gür DÖ, Emeksiz GK, Yılmaz A, Bayrakçı N, Güzel S. | 08/14/2021 |
| Microfibril associated protein 4 (MFAP4) is a carrier of the tumor associated carbohydrate sialyl-Lewis x (sLe(x)) in pancreatic adenocarcinoma. | Microfibril associated protein 4 (MFAP4) is a carrier of the tumor associated carbohydrate sialyl-Lewis x (sLe(x)) in pancreatic adenocarcinoma.
Guerrero PE, Duran A, Ortiz MR, Castro E, Garcia-Velasco A, Llop E, Peracaula R. | 07/3/2021 |
| Human Microfibrillar-Associated Protein 4 (MFAP4) Gene Promoter: A TATA-Less Promoter That Is Regulated by Retinol and Coenzyme Q10 in Human Fibroblast Cells. | Human Microfibrillar-Associated Protein 4 (MFAP4) Gene Promoter: A TATA-Less Promoter That Is Regulated by Retinol and Coenzyme Q10 in Human Fibroblast Cells.
Lin YJ, Chen AN, Yin XJ, Li C, Lin CC., Free PMC Article | 03/6/2021 |
| The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 4. | The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 4.
Osada Y, Suzuki T, Mizuta H, Mori K, Miura K, Dohmae N, Simizu S. | 12/12/2020 |
| High plasma microfibrillar-associated protein 4 is associated with reduced surgical repair in abdominal aortic aneurysms. | High plasma microfibrillar-associated protein 4 is associated with reduced surgical repair in abdominal aortic aneurysms.
Lindholt JS, Madsen M, Kirketerp-Møller KL, Schlosser A, Kristensen KL, Andersen CB, Sorensen GL. | 11/21/2020 |
| MFAP4 increases from diagnostic baseline despite intensive treatment but does not associate with synovitis at early or late stages of rheumatoid arthritis | Increased serum levels of microfibrillar-associated protein 4 (MFAP4) are not associated with clinical synovitis in rheumatoid arthritis but may reflect underlying cardiovascular comorbidity.
Issa SF, Lindegaard HM, Lorenzen T, Junker K, Christensen AF, Hørslev-Petersen K, Holmskov U, Sorensen GL, Junker P. | 07/18/2020 |
| ResultS suggest that microfibril associated protein 4 (MFAP4) plays a role in the pathogenesis of asthma. | Microfibrillar-associated protein 4 in serum is associated with asthma in Danish adolescents and young adults.
Hoffmann-Petersen B, Suffolk R, Petersen JJH, Petersen TH, Arendt K, Høst A, Halken S, Sorensen GL, Agertoft L., Free PMC Article | 01/18/2020 |
| MFAP4 was frequently downregulated in the most human cancers and high mRNA expression of MFAP4 significantly correlated with better overall survival in breast cancer. DNA hypermethylation in the promoter of MFAP4 decreased its mRNA expression. MFAP4 strongly associated with pathway in impairment and alteration of the elastic fibers | Integrated analysis of microfibrillar-associated proteins reveals MFAP4 as a novel biomarker in human cancers.
Yang J, Song H, Chen L, Cao K, Zhang Y, Li Y, Hao X. | 08/17/2019 |
| MFAP4 was present in synovial biopsies from both rheumatoid arthritis and osteoarthritis patients, particularly prominent in deep arterioles where it colocalized with elastin. The findings may suggest that MFAP4 is involved in adaptive vessel wall remodeling associated with chronic joint disease. | Site-specific absence of microfibrillar-associated protein 4 (MFAP4) from the internal elastic membrane of arterioles in the rheumatoid arthritis synovial membrane: an immunohistochemical study in patients with advanced rheumatoid arthritis versus osteoarthritis.
Christensen AF, Sorensen GL, Junker K, Revald P, Varnum C, Issa SF, Junker P, Sorensen FB. | 07/27/2019 |
| the relationship between serum MFAP4 (sMFAP4) and symptomatic peripheral artery disease outcomes, was investigated. | Microfibrillar-associated protein 4 variation in symptomatic peripheral artery disease.
Hemstra LE, Schlosser A, Lindholt JS, Sorensen GL., Free PMC Article | 06/15/2019 |
| the applicability of MFAP4 as a novel serum biomarker for assessment of hepatic fibrosis and identification of high-risk patients with severe fibrosis stages in hepatitis C, is reported. | Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients.
Bracht T, Mölleken C, Ahrens M, Poschmann G, Schlosser A, Eisenacher M, Stühler K, Meyer HE, Schmiegel WH, Holmskov U, Sorensen GL, Sitek B., Free PMC Article | 10/21/2017 |
| No association between pMFAP4 and macrovascular vascular complications was found. However, high levels of pMFAP4 correlated independently with diabetic neuropathy. | Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus.
Blindbæk SL, Schlosser A, Green A, Holmskov U, Sorensen GL, Grauslund J. | 05/6/2017 |
| These studies have identified and validated new factors enriched in juvenile chondrocytes as compared to adult chondrocytes including secreted extracellular matrix factors chordin-like 1 (CHRDL1) and microfibrillar-associated protein 4 (MFAP4). | Identification of Human Juvenile Chondrocyte-Specific Factors that Stimulate Stem Cell Growth.
Taylor SE, Lee J, Smeriglio P, Razzaque A, Smith RL, Dragoo JL, Maloney WJ, Bhutani N. | 01/14/2017 |
| plasma MFAP4 was significantly increased among patients with a previous diagnosis of liver disease or congestive heart failure compared to patients with other diagnoses. | Microfibrillar-Associated Protein 4: A Potential Biomarker for Screening for Liver Fibrosis in a Mixed Patient Cohort.
Sækmose SG, Mössner B, Christensen PB, Lindvig K, Schlosser A, Holst R, Barington T, Holmskov U, Sorensen GL., Free PMC Article | 06/11/2016 |
| Data suggest that MFAP4 specifically binds tropoelastin and fibrillin-1/-2, as well as elastin cross-linking amino acid desmosine; MFAP4 co-localizes with fibrillin-1-positive fibers; MFAP4 actively promotes tropoelastin self-assembly. | Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.
Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL., Free PMC Article | 06/4/2016 |
| MFAP4 regulates integrin alphaVbeta3-induced VSMC proliferation and migration, as well as monocyte chemotaxis, and accelerates neointimal hyperplasia after vascular injury. | MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.
Schlosser A, Pilecki B, Hemstra LE, Kejling K, Kristmannsdottir GB, Wulf-Johansson H, Moeller JB, Füchtbauer EM, Nielsen O, Kirketerp-Møller K, Dubey LK, Hansen PB, Stubbe J, Wrede C, Hegermann J, Ochs M, Rathkolb B, Schrewe A, Bekeredjian R, Wolf E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Lindholt JS, Holmskov U, Sorensen GL. | 05/7/2016 |
| Serum MFAP4 varies in groups of patients with different cardiovascular conditions. | Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular conditions.
Wulf-Johansson H, Lock Johansson S, Schlosser A, Trommelholt Holm A, Rasmussen LM, Mickley H, Diederichsen AC, Munkholm H, Poulsen TS, Tornøe I, Nielsen V, Marcussen N, Vestbo J, Sækmose SG, Holmskov U, Sorensen GL., Free PMC Article | 10/18/2014 |
| The findings support the biomarker potential of systemic MFAP4, with elevated levels in the serum reflecting pathological processes involving ECM remodeling and degradation. | Enzyme-linked immunosorbent assay characterization of basal variation and heritability of systemic microfibrillar-associated protein 4.
Sækmose SG, Schlosser A, Holst R, Johansson SL, Wulf-Johansson H, Tornøe I, Vestbo J, Kyvik KO, Barington T, Holmskov U, Sørensen GL., Free PMC Article | 08/9/2014 |
| skin with enhanced MFAP-4 expression was protected from UVB-induced photodamage/photoaging accompanied by the prevention of ECM degradation and aggravated elasticity | Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection.
Kasamatsu S, Hachiya A, Fujimura T, Sriwiriyanont P, Haketa K, Visscher MO, Kitzmiller WJ, Bello A, Kitahara T, Kobinger GP, Takema Y., Free PMC Article | 09/14/2013 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)., Free PMC Article | 09/15/2010 |