| MEN1 Deficiency-Driven Activation of the beta-Catenin-MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance. | MEN1 Deficiency-Driven Activation of the β-Catenin-MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance.
Xu J, Lou X, Wang F, Zhang W, Xu X, Ye Z, Zhuo Q, Wang Y, Jing D, Fan G, Chen X, Zhang Y, Zhou C, Chen J, Qin Y, Yu X, Ji S., Free PMC Article | 10/1/2024 |
| Menin signaling and therapeutic targeting in breast cancer. | Menin signaling and therapeutic targeting in breast cancer.
Liu P, Shi C, Qiu L, Shang D, Lu Z, Tu Z, Liu H. | 08/19/2024 |
| Investigating the Effects of Amino Acid Variations in Human Menin. | Investigating the Effects of Amino Acid Variations in Human Menin.
Biancaniello C, D'Argenio A, Giordano D, Dotolo S, Scafuri B, Marabotti A, d'Acierno A, Tagliaferri R, Facchiano A., Free PMC Article | 08/11/2024 |
| Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice. | Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice.
Fuentes ME, Lu X, Flores NM, Hausmann S, Mazur PK., Free PMC Article | 04/17/2024 |
| Multiple endocrine neoplasia type 1 with Zollinger-Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry. | Multiple endocrine neoplasia type 1 with Zollinger-Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry.
Kimura N, Hirata Y, Iwashiro N, Kijima H, Takayasu S, Yamagata S, Sakihara S, Uchino S, Ohara M., Free PMC Article | 12/6/2023 |
| Dependency of B-Cell Acute Lymphoblastic Leukemia and Multiple Myeloma Cell Lines on MEN1 Extends beyond MEN1-KMT2A Interaction. | Dependency of B-Cell Acute Lymphoblastic Leukemia and Multiple Myeloma Cell Lines on MEN1 Extends beyond MEN1-KMT2A Interaction.
Wolffhardt TM, Ketzer F, Telese S, Wirth T, Ushmorov A., Free PMC Article | 12/4/2023 |
| Blood-based Proteomic Signatures Associated With MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression. | Blood-based Proteomic Signatures Associated With MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression.
Fahrmann JF, Wasylishen AR, Pieterman CRC, Irajizad E, Vykoukal J, Wu R, Dennison JB, Peterson CB, Zhao H, Do KA, Halperin DM, Agarwal SK, Blau JE, Jha S, Rivero JD, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM, Katayama H., Free PMC Article | 11/22/2023 |
| MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation. | MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation.
Jin B, Zhu J, Pan T, Yang Y, Liang L, Zhou Y, Zhang T, Teng Y, Wang Z, Wang X, Tian Q, Guo B, Li H, Chen T., Free PMC Article | 08/30/2023 |
| Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover. | Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover.
Duan S, Sheriff S, Elvis-Offiah UB, Witten BL, Sawyer TW, Sundaresan S, Cierpicki T, Grembecka J, Merchant JL., Free PMC Article | 07/27/2023 |
| Evaluating the role of MEN1 gene expression and its clinical significance in breast cancer patients. | Evaluating the role of MEN1 gene expression and its clinical significance in breast cancer patients.
Massey S, Khan MA, Rab SO, Mustafa S, Khan A, Malik Z, Shaik R, Verma MK, Deo S, Husain SA., Free PMC Article | 07/17/2023 |
| MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression. | MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression.
Xu J, Ye Z, Zhuo Q, Gao H, Qin Y, Lou X, Zhang W, Wang F, Wang Y, Jing D, Fan G, Zhang Y, Chen X, Chen J, Xu X, Yu X, Ji S. | 07/7/2023 |
| MENIN-mediated regulation of gastrin gene expression and its role in gastrinoma development. | MENIN-mediated regulation of gastrin gene expression and its role in gastrinoma development.
Elvis-Offiah UB, Duan S, Merchant JL. | 05/11/2023 |
| MEN1 mutations mediate clinical resistance to menin inhibition. | MEN1 mutations mediate clinical resistance to menin inhibition.
Perner F, Stein EM, Wenge DV, Singh S, Kim J, Apazidis A, Rahnamoun H, Anand D, Marinaccio C, Hatton C, Wen Y, Stone RM, Schaller D, Mowla S, Xiao W, Gamlen HA, Stonestrom AJ, Persaud S, Ener E, Cutler JA, Doench JG, McGeehan GM, Volkamer A, Chodera JD, Nowak RP, Fischer ES, Levine RL, Armstrong SA, Cai SF., Free PMC Article | 04/6/2023 |
| Multiple Endocrine Neoplasia Type 1 Syndrome Pancreatic Neuroendocrine Tumor Genotype/Phenotype: Is There Any Advance on Predicting or Preventing? | Multiple Endocrine Neoplasia Type 1 Syndrome Pancreatic Neuroendocrine Tumor Genotype/Phenotype: Is There Any Advance on Predicting or Preventing?
Ramamoorthy B, Nilubol N., Free PMC Article | 03/22/2023 |
| Menin "reads" H3K79me2 mark in a nucleosomal context. | Menin "reads" H3K79me2 mark in a nucleosomal context.
Lin J, Wu Y, Tian G, Yu D, Yang E, Lam WH, Liu Z, Jing Y, Dang S, Bao X, Wong JWH, Zhai Y, Li XD. | 03/2/2023 |
| [Casuistic cases of parathyroid carcinoma with a verified mutation in the MEN1 gene]. | [Casuistic cases of parathyroid carcinoma with a verified mutation in the MEN1 gene].
Pylina SV, Kim EI, Bondarenko EV, Krupinova JA, Eremkina AK, Mokrysheva NG., Free PMC Article | 03/1/2023 |
| MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors. | MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors.
Ye Z, Chen H, Ji S, Hu Y, Lou X, Zhang W, Jing D, Fan G, Zhang Y, Chen X, Zhuo Q, Chen J, Xu X, Yu X, Xu J, Qin Y, Gao H., Free PMC Article | 01/14/2023 |
| Loss of MEN1 leads to renal fibrosis and decreases HGF-Adamts5 pathway activity via an epigenetic mechanism. | Loss of MEN1 leads to renal fibrosis and decreases HGF-Adamts5 pathway activity via an epigenetic mechanism.
Jin B, Zhu J, Zhou Y, Liang L, Yang Y, Xu L, Zhang T, Li P, Pan T, Guo B, Chen T, Li H., Free PMC Article | 08/20/2022 |
| Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity. | Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity.
Dreijerink KMA, Ozyerli-Goknar E, Koidl S, van der Lelij EJ, van den Heuvel P, Kooijman JJ, Biniossek ML, Rodenburg KW, Nizamuddin S, Timmers HTM., Free PMC Article | 08/20/2022 |
| MEN1 silencing triggers the dysregulation of mTORC1 and MYC pathways in ER+ breast cancer cells. | MEN1 silencing triggers the dysregulation of mTORC1 and MYC pathways in ER+ breast cancer cells.
Abou Ziki R, Teinturier R, Luo Y, Cerutti C, Vanacker JM, Poulard C, Bachelot T, Diab-Assaf M, Treilleux I, Zhang CX, Le Romancer M. | 08/6/2022 |
| Multiple endocrine neoplasia type 1 caused by mosaic mutation: clinical follow-up and genetic counseling? | Multiple endocrine neoplasia type 1 caused by mosaic mutation: clinical follow-up and genetic counseling?
Coppin L, Giraud S, Pasmant E, Lagarde A, North MO, Le-Collen L, Aubert V, Mougel G, Ladsous M, Louboutin A, Brixi H, Haissaguerre M, Scheyer N, Klein M, Tabarin A, Delemer B, Barlier A, Odou MF, Romanet P. | 05/28/2022 |
| Distinct clinical phenotypes in a family with a novel truncating MEN1 frameshift mutation. | Distinct clinical phenotypes in a family with a novel truncating MEN1 frameshift mutation.
Welsch C, Flügel AK, Rondot S, Schulze E, Sircar I, Nußbaumer J, Bojunga J., Free PMC Article | 05/14/2022 |
| A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis. | A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.
Zeng J, Xiao XQ, Zhou ZY., Free PMC Article | 05/7/2022 |
| Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors. | Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors.
Lakiza O, Lutze J, Vogle A, Williams J, Abukdheir A, Miller P, Liao C', Pitroda SP, Martinez C, Olivas A, Setia N, Kron SJ, Weichselbaum RR, Keutgen XM., Free PMC Article | 04/23/2022 |
| Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells. | Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells.
Wagener N, Buchholz M, Bertolino P, Zhang CX, Di Fazio P., Free PMC Article | 03/26/2022 |