| Apoptosis Signal-Regulated Kinase-1 Promotes Nucleus Pulposus Cell Senescence and Apoptosis to Regulate Intervertebral Disc Degeneration. | Apoptosis Signal-Regulated Kinase-1 Promotes Nucleus Pulposus Cell Senescence and Apoptosis to Regulate Intervertebral Disc Degeneration.
Zou M, Chen W, Li J, Qi X, Wang X, Liu F, Hu J, Zhang Q. | 08/31/2024 |
| Multiple Pathway-Dephosphorylated ASK-1 Confers Temozolomide-Resistance to Human Glioma Cells. | Multiple Pathway-Dephosphorylated ASK-1 Confers Temozolomide-Resistance to Human Glioma Cells.
Gao K, She K, Fan J, Shao L, Ji Z. | 02/7/2024 |
| [Tumor antigen-loaded dendritic cells combined with cytokine-induced killer (CIK) enhance the killing activity of human esophageal cancer cells by promoting ASK1 activation]. | [Tumor antigen-loaded dendritic cells combined with cytokine-induced killer (CIK) enhance the killing activity of human esophageal cancer cells by promoting ASK1 activation].
Duan Z, Li H, Hu B, Li Y, Huang L. | 06/23/2023 |
| Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology. | Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology.
Shen WB, Elahi M, Wang B, Zhan M, Yang P, Yang P. | 11/26/2022 |
| Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability. | Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability.
Giri H, Srivastava AK, Naik UP., Free PMC Article | 10/1/2022 |
| Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study. | Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study.
Xie Y, Cao P, Qin Y, Wu X, Huang B, Liu K, Liu Y. | 08/13/2022 |
| Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target. | Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target.
Singh V, Huang E, Pathak V, Willard BB, Allende DS, Nagy LE., Free PMC Article | 07/30/2022 |
| Clinical investigation of lipopolysaccharide in the persistence of metabolic syndrome (MS) through the activation of GRP78-IRE1alpha-ASK1 signaling pathway. | Clinical investigation of lipopolysaccharide in the persistence of metabolic syndrome (MS) through the activation of GRP78-IRE1α-ASK1 signaling pathway.
Wang X, Zhang H, Zhang P, Hao S, Yang X, Zhou X. | 03/26/2022 |
| Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway. | Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway.
Zhang Z, Wang L, Liu Y, Luan Y, Zhu K, Tian Y, Liu Y, Zheng X. | 03/26/2022 |
| Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions. | Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions.
Obsilova V, Honzejkova K, Obsil T., Free PMC Article | 01/22/2022 |
| A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis. | A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis.
Wang T, Liu Z, She Y, Deng J, Zhong Y, Zhao M, Li S, Xie D, Sun X, Hu X, Chen C. | 01/8/2022 |
| ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes. | ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes.
Fang PP, Pan CW, Lin W, Li J, Huang SS, Zhou GY, Du WJ, Li Q., Free PMC Article | 11/6/2021 |
| Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases. | Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.
Trevelyan SJ, Brewster JL, Burgess AE, Crowther JM, Cadell AL, Parker BL, Croucher DR, Dobson RCJ, Murphy JM, Mace PD. | 11/6/2021 |
| MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway. | MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway.
Dinesh P, Kalaiselvan S, Sujitha S, Rasool M. | 10/9/2021 |
| Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge. | Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge.
Miller MR, Koch SR, Choi H, Lamb FS, Stark RJ., Free PMC Article | 08/14/2021 |
| Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease. | Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease.
Morris BJ, Chen R, Donlon TA, Masaki KH, Willcox DC, Allsopp RC, Willcox BJ., Free PMC Article | 07/24/2021 |
| Redundant role of ASK1-mediated p38MAPK activation in human platelet function. | Redundant role of ASK1-mediated p38MAPK activation in human platelet function.
Sledz KM, Moore SF, Vijayaragavan V, Mallah S, Goudswaard LJ, Williams CM, Hunter RW, Hers I. | 06/12/2021 |
| Mechanisms of Trx2/ASK1-Mediated Mitochondrial Injury in Pemphigus Vulgaris. | Mechanisms of Trx2/ASK1-Mediated Mitochondrial Injury in Pemphigus Vulgaris.
Wei B, Li F., Free PMC Article | 05/29/2021 |
| The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress. | The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress.
Psenakova K, Hexnerova R, Srb P, Obsilova V, Veverka V, Obsil T. | 01/23/2021 |
| these results suggest that in resting platelets ASK1 is bound to CIB1 at low Ca2+ concentrations. Agonist-induced platelet activation causes an increase in intracellular Ca2+ concentration that leads to the dissociation of CIB1 from ASK1, allowing for proper dimerization through ASK1 N-terminal coiled-coil (NCC) domains. | Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets.
Patel P, Naik MU, Golla K, Shaik NF, Naik UP., Free PMC Article | 07/11/2020 |
| The discovery of novel ASK1 inhibitors would have a wide range of applications in medical science. In-silico techniques have been successfully used in the design of some novel ASK1 inhibitors. The use of machine learning-based approaches in combination with structure-based virtual screening (SBVS) and ligand-based virtual screening (LBVS) will be helpful toward the development of potent ASK1 inhibitors | ASK1 and its role in cardiovascular and other disorders: available treatments and future prospects.
Baig MH, Baker A, Ashraf GM, Dong JJ. | 06/13/2020 |
| This review summarized experimental evidences regarding the association between ASK1 and the pathogenesis of various diseases. [review] | Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders.
Cheon SY, Cho KJ. | 05/30/2020 |
| Herein, the authors identify apoptosis signal-regulating kinase 1 (ASK1) as a suppressor of non-alcoholic steatohepatitis and fibrosis formation. | Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis.
Challa TD, Wueest S, Lucchini FC, Dedual M, Modica S, Borsigova M, Wolfrum C, Blüher M, Konrad D., Free PMC Article | 04/18/2020 |
| Increased ASK1 expression level inhibited cell migration and proliferation of gastric cancer cells. | The Elevated ASK1 Expression Inhibits Proliferation and Invasion in Gastric Cancer HGC-27 Cells.
Wan X, Shi L, Ma X, Tang H, Wu G. | 10/26/2019 |
| LATS2 interacts with ASK1 and increases ASK1-mediated signaling to promote apoptosis and activate the JNK mitogen-activated protein kinase (MAPK). | Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.
Rusnak L, Tang C, Qi Q, Mo X, Fu H., Free PMC Article | 09/21/2019 |