| A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism. | A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism.
Thapa N, Chen M, Cryns VL, Anderson R., Free PMC Article | 06/13/2024 |
| MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma. | MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma.
Xia X, Ge Y, Ge F, Gu P, Liu Y, Li P, Xu P., Free PMC Article | 02/16/2024 |
| Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology. | Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.
Nishida K, Matsumura K, Tamura M, Nakamichi T, Shimamori K, Kuragano M, Kabir AMR, Kakugo A, Kotani S, Nishishita N, Tokuraku K., Free PMC Article | 06/2/2023 |
| Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4. | Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4.
Thapa N, Chen M, Horn HT, Choi S, Wen T, Anderson RA., Free PMC Article | 02/2/2021 |
| study reveals a molecular mechanism by which HPV16E7 perturbs host mitotic progression by interfering Mps1-MAP4 signaling cascade, which results in an extended infection window and may facilitate the persistent HPV16 infection | Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade.
Guo Y, Zhang X, Xu Q, Gong F, Shi X, Li C, Huang R, Nie F, Zhu W, Li J, Tang J, Li R, Zhang L, Chen L, Ma RZ. | 02/15/2020 |
| The strongest bond of MAP4 was found around the intertubulin-dimer interface such that MAP4 coexists on the microtubule with kinesin-1 bound to the intratubulin-dimer interface as well. | Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs.
Shigematsu H, Imasaki T, Doki C, Sumi T, Aoki M, Uchikubo-Kamo T, Sakamoto A, Tokuraku K, Shirouzu M, Nitta R., Free PMC Article | 09/28/2019 |
| Further experiments revealed that MAP4 regulates microtubule dynamics and promotes epidermal cell migration through Tctex-1. MAP4 and Tctex-1 play important roles in regulating the migration of epidermal cells under hypoxia. | MAP4 regulates Tctex-1 and promotes the migration of epidermal cells in hypoxia.
Chen X, Zhou X, Shi X, Xia X, Zhang Y, Fan D. | 08/17/2019 |
| Results suggest that Syk, MAP4, and calpain-1 expression are correlated with each other and these proteins may be involved in early stages of tumour spread. | Expression of Syk and MAP4 proteins in ovarian cancer.
Zhang S, Deen S, Storr SJ, Yao A, Martin SG., Free PMC Article | 04/20/2019 |
| Expression level of MAP4 mRNA and protein in lung adenocarcinoma tissues were significantly higher than those in noncancerous tissues. MAP4 expression significantly correlated with tumor progression. | Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.
Xia X, He C, Wu A, Zhou J, Wu J., Free PMC Article | 09/22/2018 |
| Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. | MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1-IRF3 signaling axis.
Seo M, Lee SO, Kim JH, Hong Y, Kim S, Kim Y, Min DH, Kong YY, Shin J, Ahn K., Free PMC Article | 04/7/2018 |
| an intratumoral injection of MAP4-small interfering RNA (siRNA) remarkably inhibited the growth of the tumors that formed by the MAP4-expressing ESCC cells in nude mice, and a combination of MAP4-siRNA and Bevacizumab significantly enhanced the inhibition effect. Our data suggest that MAP4 is probably a useful prognostic biomarker and a potential therapeutic target for the disease. | Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma.
Jiang YY, Shang L, Shi ZZ, Zhang TT, Ma S, Lu CC, Zhang Y, Hao JJ, Shi C, Shi F, Xu X, Cai Y, Jia XM, Zhan QM, Wang MR. | 09/9/2017 |
| MAP4 acts as a checkpoint molecule that balances positive and negative hallmarks of T cell activation. | Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation.
Bustos-Morán E, Blas-Rus N, Martin-Cófreces NB, Sánchez-Madrid F., Free PMC Article | 08/5/2017 |
| Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure. | Filtering genetic variants and placing informative priors based on putative biological function.
Friedrichs S, Malzahn D, Pugh EW, Almeida M, Liu XQ, Bailey JN., Free PMC Article | 11/5/2016 |
| We demonstrated that the MAP4 (Ser696 and Ser787) phosphorylation increased concomitantly with the p38/MAPK pathway activation by the LPS and TNF-alpha stimulation of HPMECs, which induced MT disassembly followed by hyperpermeability. | P38/MAPK contributes to endothelial barrier dysfunction via MAP4 phosphorylation-dependent microtubule disassembly in inflammation-induced acute lung injury.
Li L, Hu J, He T, Zhang Q, Yang X, Lan X, Zhang D, Mei H, Chen B, Huang Y., Free PMC Article | 12/5/2015 |
| Results demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature. | MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and Golgi architecture as a central mechanism in growth regulation.
Zahnleiter D, Hauer NN, Kessler K, Uebe S, Sugano Y, Neuhauss SC, Giessl A, Ekici AB, Blessing H, Sticht H, Dörr HG, Reis A, Thiel CT. | 09/12/2015 |
| Data show that cAMP/alpha isoform of the catalytic subunit of human PKA (PKAc-alpha) signaling can disrupt microtubule (MT) cytoskeleton by the phosphorylation of microtubule-Associated Protein 4 (MAP4). | Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics.
Ou Y, Zheng X, Gao Y, Shu M, Leng T, Li Y, Yin W, Zhu W, Huang Y, Zhou Y, Tang J, Qiu P, Yan G, Hu J, Ruan H, Hu H. | 09/27/2014 |
| MAP4, which is a binding partner of SEPT2. | Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length.
Ghossoub R, Hu Q, Failler M, Rouyez MC, Spitzbarth B, Mostowy S, Wolfrum U, Saunier S, Cossart P, Jamesnelson W, Benmerah A., Free PMC Article | 03/1/2014 |
| there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization | MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1.
Fang YD, Xu X, Dang YM, Zhang YM, Zhang JP, Hu JY, Zhang Q, Dai X, Teng M, Zhang DX, Huang YS., Free PMC Article | 07/21/2012 |
| DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation. | Knockdown of MAP4 and DNAL1 produces a post-fusion and pre-nuclear translocation impairment in HIV-1 replication.
Gallo DE, Hope TJ., Free PMC Article | 01/21/2012 |
| Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis. | MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.
Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD. | 12/10/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK., Free PMC Article | 12/2/2009 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC. | 12/2/2009 |
| Data found the ratio of MAP4 to stathmin mRNA was found to be higher in diseased lung tissues compared to normal lung tissues, suggesting this ratio might also be used as a clinically relevant biomarker for NSCLCs. | Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas.
Cucchiarelli V, Hiser L, Smith H, Frankfurter A, Spano A, Correia JJ, Lobert S. | 01/21/2010 |
| activity of MAP4 is downregulated by reduced free tubulin concentrations | Interphase and monoastral-mitotic phenotypes of overexpressed MAP4 are modulated by free tubulin concentrations.
Holmfeldt P, Brattsand G, Gullberg M. | 01/21/2010 |
| MAP4 microtubule decoration interferes with beta-adrenergic receptor recycling and that this may be one mechanism for beta-adrenergic receptor downregulation in heart failure. | Inhibition of beta-adrenergic receptor trafficking in adult cardiocytes by MAP4 decoration of microtubules.
Cheng G, Qiao F, Gallien TN, Kuppuswamy D, Cooper G 4th. | 01/21/2010 |