| MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients. | MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients.
Zheng R, Yao B, Ye Y, Luo R, Wu Z, Hu X, Yuan Y, Pan X, Liu C, Huang L, Luo Y, Yang D, Shang N, Tian Y, Jia J. | 05/8/2024 |
| MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2. | MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2.
Sinha A, Ghosh A, Ghosh A, Mathai S, Bhaumik J, Mukhopadhyay A, Maitra A, Biswas NK, Sengupta S., Free PMC Article | 03/28/2024 |
| MAL protein suppresses the metastasis and invasion of GC cells by interfering with the phosphorylation of STAT3. | MAL protein suppresses the metastasis and invasion of GC cells by interfering with the phosphorylation of STAT3.
Geng Z, Li J, Li S, Wang Y, Zhang L, Hu Q, Wang X, Zuo L, Song X, Zhang X, Ge S, Hu J., Free PMC Article | 03/26/2022 |
| Differentiation and activation of human CD4 T cells is associated with a gradual loss of myelin and lymphocyte protein. | Differentiation and activation of human CD4 T cells is associated with a gradual loss of myelin and lymphocyte protein.
Leitner J, Mahasongkram K, Schatzlmaier P, Pfisterer K, Leksa V, Pata S, Kasinrerk W, Stockinger H, Steinberger P., Free PMC Article | 09/25/2021 |
| Clostridium perfringens epsilon toxin binds to erythrocyte MAL receptors and triggers phosphatidylserine exposure. | Clostridium perfringens epsilon toxin binds to erythrocyte MAL receptors and triggers phosphatidylserine exposure.
Geng Z, Huang J, Kang L, Gao S, Yuan Y, Li Y, Wang J, Xin W, Wang J., Free PMC Article | 05/1/2021 |
| Experiments on lymphocytic cell lines revealed that MAL protein-expressing T cells, but not B cells, are sensitive to Epsilon toxin (Etx) from Clostridium perfringens and reveal that the toxin may be used as a molecular tool to distinguish subpopulations of lymphocytes. | The Cytotoxicity of Epsilon Toxin from Clostridium perfringens on Lymphocytes Is Mediated by MAL Protein Expression.
Blanch M, Dorca-Arévalo J, Not A, Cases M, Gómez de Aranda I, Martínez-Yélamos A, Martínez-Yélamos S, Solsona C, Blasi J., Free PMC Article | 06/29/2019 |
| In high-grade serous ovarian carcinoma patients, MAL was overexpressed in platinum-resistant compared to platinum-sensitive patients and resulted as an independent prognostic marker of survival. | MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis.
Zanotti L, Romani C, Tassone L, Todeschini P, Tassi RA, Bandiera E, Damia G, Ricci F, Ardighieri L, Calza S, Marchini S, Beltrame L, Tognon G, D'Incalci M, Pecorelli S, Sartori E, Odicino F, Ravaggi A, Bignotti E., Free PMC Article | 03/3/2018 |
| MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer. | MAL and TMEM220 are novel DNA methylation markers in human gastric cancer.
Choi B, Han TS, Min J, Hur K, Lee SM, Lee HJ, Kim YJ, Yang HK. | 02/4/2017 |
| This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas | Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.
Iwasaki T, Matsushita M, Nonaka D, Nagata K, Kato M, Kuwamoto S, Murakami I, Hayashi K. | 06/11/2016 |
| CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia | CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies.
van Baars R, van der Marel J, Snijders PJ, Rodriquez-Manfredi A, ter Harmsel B, van den Munckhof HA, Ordi J, del Pino M, van de Sandt MM, Wentzensen N, Meijer CJ, Quint WG. | 05/28/2016 |
| Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. | DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer.
Kalmár A, Péterfia B, Hollósi P, Galamb O, Spisák S, Wichmann B, Bodor A, Tóth K, Patai ÁV, Valcz G, Nagy ZB, Kubák V, Tulassay Z, Kovalszky I, Molnár B., Free PMC Article | 04/23/2016 |
| Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL. | The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.
Rumah KR, Ma Y, Linden JR, Oo ML, Anrather J, Schaeren-Wiemers N, Alonso MA, Fischetti VA, McClain MS, Vartanian T., Free PMC Article | 04/9/2016 |
| The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus. | Methylation Levels of CADM1, MAL, and MIR124-2 in Cervical Scrapes for Triage of HIV-Infected, High-Risk HPV-Positive Women in Kenya.
De Vuyst H, Franceschi S, Plummer M, Mugo NR, Sakr SR, Meijer CJ, Heideman DA, Tenet V, Snijders PJ, Hesselink AT, Chung MH. | 01/30/2016 |
| MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells. | Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells.
Ventimiglia LN, Fernández-Martín L, Martínez-Alonso E, Antón OM, Guerra M, Martínez-Menárguez JA, Andrés G, Alonso MA. | 10/31/2015 |
| MAL hypermethylation is associated with esophageal carcinoma progression. | MAL hypermethylation is a tissue-specific event that correlates with MAL mRNA expression in esophageal carcinoma.
Jin Z, Wang L, Zhang Y, Cheng Y, Gao Y, Feng X, Dong M, Cao Z, Chen S, Yu H, Zhao Z, Zhang X, Liu J, Mori Y, Fan X, Meltzer SJ., Free PMC Article | 10/17/2015 |
| Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women. | Follow-up of high-risk HPV positive women by combined cytology and bi-marker CADM1/MAL methylation analysis on cervical scrapes.
Verhoef VM, van Kemenade FJ, Rozendaal L, Heideman DA, Bosgraaf RP, Hesselink AT, Melchers WJ, Massuger LF, Bekkers RL, Steenbergen RD, Berkhof J, Snijders PJ, Meijer CJ. | 05/30/2015 |
| DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer | CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer.
De Strooper LM, van Zummeren M, Steenbergen RD, Bleeker MC, Hesselink AT, Wisman GB, Snijders PJ, Heideman DA, Meijer CJ. | 01/24/2015 |
| The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer. | Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality.
Kurashige J, Sawada G, Takahashi Y, Eguchi H, Sudo T, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Kawanaka H, Uchiyama H, Yamashita Y, Morita M, Oki E, Saeki H, Sugimachi K, Watanabe M, Mori M, Baba H, Mimori K. | 04/5/2014 |
| CADM1 and MAL methylation levels increased proportional to severity of the underlying lesion | CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease.
Bierkens M, Hesselink AT, Meijer CJ, Heideman DA, Wisman GB, van der Zee AG, Snijders PJ, Steenbergen RD. | 09/14/2013 |
| hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. | Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer.
Suzuki M, Shiraishi K, Eguchi A, Ikeda K, Mori T, Yoshimoto K, Ohba Y, Yamada T, Ito T, Baba Y, Baba H., Free PMC Article | 09/14/2013 |
| MAL protein plays an important role during oral carcinogenesis, MAL gene expression was significantly decreased in oral squamous cell carcinoma compared with normal epithelium. | Expression of myelin and lymphocyte protein (MAL) in oral carcinogenesis.
Pal SK, Noguchi S, Yamamoto G, Yamada A, Isobe T, Hayashi S, Tanaka J, Tanaka Y, Kamijo R, Yamane GY, Tachikawa T. | 07/27/2013 |
| Data indicate that DNA methylation status of multiple genes CADM1, MAL and hsa-miR-124-2 was analyzed in human papillomavirus (hrHPV)-positive cervical scrape. | Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape.
Snellenberg S, De Strooper LM, Hesselink AT, Meijer CJ, Snijders PJ, Heideman DA, Steenbergen RD., Free PMC Article | 05/25/2013 |
| the methylation marker panel CADM1-M18 and MAL-M1 may serve as an alternative molecular triage tool for hrHPV-positive women. | Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women.
Overmeer RM, Louwers JA, Meijer CJ, van Kemenade FJ, Hesselink AT, Daalmeijer NF, Wilting SM, Heideman DA, Verheijen RH, Zaal A, van Baal WM, Berkhof J, Snijders PJ, Steenbergen RD. | 01/26/2013 |
| Data show that a combination of CADM1 and MAL methylation could represent a promising candidate triage tool for hrHPV-positive women. | Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women.
Hesselink AT, Heideman DA, Steenbergen RD, Coupé VM, Overmeer RM, Rijkaart D, Berkhof J, Meijer CJ, Snijders PJ. | 10/1/2011 |
| Data show that MAL regulates membrane order and the distribution of microtubule and transport vesicle docking machinery at the IS and, by doing so, ensures correct protein sorting of Lck and LAT to the cSMAC. | MAL protein controls protein sorting at the supramolecular activation cluster of human T lymphocytes.
Antón OM, Andrés-Delgado L, Reglero-Real N, Batista A, Alonso MA. | 08/13/2011 |