| Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-kappaB pathway, and elevated MMP13 expression. | Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression.
Jin Y, Eum DY, Lee C, Park SY, Shim JW, Choi YJ, Choi SH, Kim JG, Heo K, Park SJ. | 03/15/2024 |
| TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC. | TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC.
Yang SB, Zhou ZH, Lei J, Li XW, Chen Q, Li B, Zhang YW, Ge YZ, Zuo S., Free PMC Article | 04/26/2023 |
| Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension. | Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension.
Hong J, Wong B, Huynh C, Tang B, Ruffenach G, Li M, Umar S, Yang X, Eghbali M., Free PMC Article | 04/5/2023 |
| MicroRNA-501-3p targeting TM4SF1 facilitates tumor-related behaviors of gastric cancer cells via EMT signaling pathway. | MicroRNA-501-3p targeting TM4SF1 facilitates tumor-related behaviors of gastric cancer cells via EMT signaling pathway.
Wei Y, Yin L, Xie X, Wu Z, Zhang J, Gao Y, Tang J. | 12/17/2022 |
| TM4SF1 promotes glioma malignancy through multiple mechanisms. | TM4SF1 promotes glioma malignancy through multiple mechanisms.
Zheng YW, Wang M, Zhong ZM, Wu GQ, Zhang T, Chen LL, Li M. | 08/20/2022 |
| TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin alpha6. | TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin α6.
Hou S, Hao X, Li J, Weng S, Wang J, Zhao T, Li W, Hu X, Deng B, Gu J, Hang Q., Free PMC Article | 07/30/2022 |
| Long Noncoding RNA BCYRN1 Recruits BATF to Promote TM4SF1 Upregulation and Enhance HCC Cell Proliferation and Invasion. | Long Noncoding RNA BCYRN1 Recruits BATF to Promote TM4SF1 Upregulation and Enhance HCC Cell Proliferation and Invasion.
Liu Y, Liu MJ, Jiao M, Jiang LL, Fu X, Wang WJ., Free PMC Article | 06/25/2022 |
| Hyper-expression and hypomethylation of TM4SF1 are associated with lymph node metastases in papillary thyroid carcinoma patients. | Hyper-expression and hypomethylation of TM4SF1 are associated with lymph node metastases in papillary thyroid carcinoma patients.
Wang K, Zheng J, Wu Z, Fang JG, Zhao JY, Yao JM, Dong JJ, Bai J, Liao L. | 04/16/2022 |
| HIF-1alpha-activated TM4SF1-AS1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by enhancing TM4SF1 expression. | HIF-1α-activated TM4SF1-AS1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by enhancing TM4SF1 expression.
Zeng Z, Shi Z, Liu Y, Zhao J, Lu Q, Guo J, Liu X, Huang D, Xu Q. | 11/22/2021 |
| TM4SF1, a binding protein of DVL2 in hepatocellular carcinoma, positively regulates beta-catenin/TCF signalling. | TM4SF1, a binding protein of DVL2 in hepatocellular carcinoma, positively regulates beta-catenin/TCF signalling.
Zhu C, Luo X, Wu J, Liu Y, Liu L, Ma S, Xie R, Wang S, Ji W., Free PMC Article | 09/25/2021 |
| TM4SF1 promotes EMT and cancer stemness via the Wnt/beta-catenin/SOX2 pathway in colorectal cancer. | TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer.
Tang Q, Chen J, Di Z, Yuan W, Zhou Z, Liu Z, Han S, Liu Y, Ying G, Shu X, Di M., Free PMC Article | 08/7/2021 |
| TM4SF1 facilitates non-small cell lung cancer progression through regulating YAP-TEAD pathway. | TM4SF1 facilitates non-small cell lung cancer progression through regulating YAP-TEAD pathway.
Fu XY, Zhou WB, Xu J. | 03/20/2021 |
| found miR-1-3p and miR-214-5p targeted TM4SF1, inhibited TM4SF1 expression, cell proliferation, migration, and induced apoptosis in human keloid fibroblasts | TM4SF1 involves in miR-1-3p/miR-214-5p-mediated inhibition of the migration and proliferation in keloid by regulating AKT/ERK signaling.
Xu M, Sun J, Yu Y, Pang Q, Lin X, Barakat M, Lei R, Xu J. | 08/1/2020 |
| High TM4SF1 expression is associated with metastasis in prostate cancer. | Over-expression of TM4SF1 improves cell metastasis and growth by activating ERK1/2 signaling pathway in human prostate cancer.
Chen J, Wang F, Xu H, Chen D, Liu W, Wang J. | 06/20/2020 |
| These data suggested that low expression of TM4SF1 is associated with carcinogenesis and development, tumor progression and invasion of gastric cancer, and poor overall survival of patients with GC. TM4SF1 is a tumor suppressor for GC and a novel prognostic marker for patients with GC. | Clinical significance of TM4SF1 as a tumor suppressor gene in gastric cancer.
Peng XC, Zeng Z, Huang YN, Deng YC, Fu GH., Free PMC Article | 11/2/2019 |
| our data provide the first evidence that TM4SF1 is a direct target of miR-30a/c and miR-30a/c inhibits the stemness and proliferation of NSCLC cells by targeting TM4SF1, suggesting that miR-30a/c and TM4SF1 may be useful as tumor biomarkers for the diagnosis and treatment of NSCLC patients. | miR-30 Family Reduction Maintains Self-Renewal and Promotes Tumorigenesis in NSCLC-Initiating Cells by Targeting Oncogene TM4SF1.
Ma YS, Yu F, Zhong XM, Lu GX, Cong XL, Xue SB, Xie WT, Hou LK, Pang LJ, Wu W, Zhang W, Cong LL, Liu T, Long HD, Sun R, Sun HY, Lv ZW, Wu CY, Fu D., Free PMC Article | 10/5/2019 |
| Results find that TM4SF1 has selective expression features in epithelial ovarian tumors, can mediate tumor cell growth and invasion, as well as metastasis, and is closely associated with anti-tumor immune responses. | TM4SF1 is a potential target for anti-invasion and metastasis in ovarian cancer.
Gao C, Yao H, Liu H, Feng Y, Yang Z., Free PMC Article | 07/6/2019 |
| These results could be reversed by the overexpression of TM4SF1. At last, up-regulation of miR-206 suppressed expression of p-AKT and p-ERK by targetting TM4SF1 in PGE2-induced cells.Our results provide further evidence that miR-206 has a protective effect on PGE2-induced colon carcinogenesis. | MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1.
Park YR, Seo SY, Kim SL, Zhu SM, Chun S, Oh JM, Lee MR, Kim SH, Kim IH, Lee SO, Lee ST, Kim SW., Free PMC Article | 05/18/2019 |
| our study provides a novel regulatory pathway involving TM4SF1, DDR1, MMP2 and MMP9, which promotes the formation and function of invadopodia to support cell migration and invasion in pancreatic cancer. | TM4SF1 Promotes Metastasis of Pancreatic Cancer via Regulating the Expression of DDR1.
Yang JC, Zhang Y, He SJ, Li MM, Cai XL, Wang H, Xu LM, Cao J., Free PMC Article | 12/1/2018 |
| Regulation of transmembrane-4-L-six-family-1 (TM4SF1) on bladder cancer cell could be induced by peroxisome proliferator-activated receptor gamma (PPARgamma)-sirtuin 1 (SIRT1) feedback loop. | TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARγ-SIRT1 feedback loop in human bladder cancer cells.
Cao R, Wang G, Qian K, Chen L, Ju L, Qian G, Wu CL, Dan HC, Jiang W, Wu M, Xiao Y, Wang X. | 10/27/2018 |
| TM4SF1 was recognized as a direct target for miR-520f in hepatocellular carcinoma (HCC) cells where its expression was found up-regulated and inversely correlated with that of mir-520f. | microRNA-520f inhibits hepatocellular carcinoma cell proliferation and invasion by targeting TM4SF1.
Du X, Fan W, Chen Y. | 04/21/2018 |
| Results suggest that miR-30a is an important regulator of TM4SF1, VEGF, and E-cadherin for CRC lymph node metastasis, a potential new therapeutic target in CRC. | MicroRNA-30a-5p (miR-30a) regulates cell motility and EMT by directly targeting oncogenic TM4SF1 in colorectal cancer.
Park YR, Kim SL, Lee MR, Seo SY, Lee JH, Kim SH, Kim IH, Lee SO, Lee ST, Kim SW. | 11/25/2017 |
| High TM4SF1 expression is associated with esophageal cancer. | TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141.
Xue L, Yu X, Jiang X, Deng X, Mao L, Guo L, Fan J, Fan Q, Wang L, Lu SH., Free PMC Article | 10/7/2017 |
| Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels. | Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.
Cheong JG, Song DG, Song HE, Berditchevski F, Nam SH, Jung JW, Kim HJ, Kim JE, Kim S, Ryu J, Cho CY, Lee KM, Lee JW., Free PMC Article | 08/19/2017 |
| Results indicate that the expression of transmembrane 4 L6 family member 1 (TM4SF1) is higher in pancreatic cancer tissues and pancreatic cancer cell lines than controls. | TM4SF1 Regulates Pancreatic Cancer Migration and Invasion In Vitro and In Vivo.
Cao J, Yang JC, Ramachandran V, Arumugam T, Deng DF, Li ZS, Xu LM, Logsdon CD. | 02/18/2017 |