| IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2. | IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2.
Mitra R, Richhariya S, Jayakumar S, Notani D, Hasan G. | 08/7/2021 |
| Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons. | Modulation of flight and feeding behaviours requires presynaptic IP(3)Rs in dopaminergic neurons.
Sharma A, Hasan G., Free PMC Article | 02/27/2021 |
| slow imaginal disc intercellular calcium waves (SIDICs) are mediated by the inositol-3-phosphate receptor, the endoplasmic reticulum (ER) calcium pump SERCA and the key gap junction component Inx2. | Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves.
Restrepo S, Basler K., Free PMC Article | 09/8/2018 |
| Study found that phototransduction was quantitatively unaffected not only after IP3R-RNAi, but also in IP3R-null mutants; describes novel phenotypes in photoreceptors from flies expressing the transcription factor (Gal4) used to drive RNAi expression. Results indicate that IP3R plays no significant role in Drosophila phototransduction while emphasizing the need for caution when using Gal4 drivers. | Phototransduction in Drosophila Is Compromised by Gal4 Expression but not by InsP(3) Receptor Knockdown or Mutation.
Bollepalli MK, Kuipers ME, Liu CH, Asteriti S, Hardie RC., Free PMC Article | 04/7/2018 |
| cell-specific regulation of protein synthesis by IP3R in neuroendocrine cells influences protein metabolism. | IP(3)R-mediated Ca(2+) release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress.
Megha, Hasan G., Free PMC Article | 09/16/2017 |
| after depletion of Ca(2+) stores in Drosophila, translocation of the IP3R to Endoplasmic reticulum-plasma-membrane junctions facilitates the coupling of STIM to Orai that leads to activation of Store-operated Ca(2+) entry. | Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM-Orai interactions in Drosophila neurons.
Chakraborty S, Deb BK, Chorna T, Konieczny V, Taylor CW, Hasan G., Free PMC Article | 08/5/2017 |
| The positive feedback between PLCbeta and IP3R found here may represent a common feature of the inositol-lipid signaling | Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.
Kohn E, Katz B, Yasin B, Peters M, Rhodes E, Zaguri R, Weiss S, Minke B., Free PMC Article | 04/18/2015 |
| The present study shows that itpr function in peptidergic neurons is not only necessary but also sufficient for maintaining normal lipid metabolism in Drosophila. | Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila.
Subramanian M, Jayakumar S, Richhariya S, Hasan G., Free PMC Article | 04/12/2014 |
| InsP3R function alters lipid metabolism and causes hyperphagia. | Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia.
Subramanian M, Metya SK, Sadaf S, Kumar S, Schwudke D, Hasan G., Free PMC Article | 11/2/2013 |
| Studies show that expression of transcripts related to carbohydrate and amine metabolism is altered in InsP(3) receptor mutant larvae. | Patterns of gene expression in Drosophila InsP3 receptor mutant larvae reveal a role for InsP3 signaling in carbohydrate and energy metabolism.
Kumar S, Dey D, Hasan G., Free PMC Article | 04/14/2012 |
| SelK elevates release of Ca2+ from endoplasmic reticulum by upregulating expression of inositol 1,4,5-tris-phosphate receptor. | Selenoprotein dSelK in Drosophila elevates release of Ca2+ from endoplasmic reticulum by upregulating expression of inositol 1,4,5-tris-phosphate receptor.
Ben SB, Wang QY, Xia L, Xia JZ, Cui J, Wang J, Yang F, Bai H, Shim MS, Lee BJ, Sun LG, Chen CL. | 03/3/2012 |
| Restoring InsP(3)R-mediated Ca(2+) release and SOCE in neuromodulatory cells influences systemic behaviors such as flight by regulating intracellular Ca(2+) homeostasis in a large population of neurons through a non-cell-autonomous mechanism. | Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight.
Agrawal N, Venkiteswaran G, Sadaf S, Padmanabhan N, Banerjee S, Hasan G., Free PMC Article | 07/12/2010 |
| ommatidia with a null mutation of IP(3)R degenerate by a process associated with intermittent lipid peroxidation and apoptotic activities | Time course of retinal degeneration associated with the absence of 1, 4, 5-inositol trisphosphate receptor in Drosophila melanogaster.
Vázquez-Martínez O, Loranca A, Palma-Tirado L, Wischin-Fuentes S, Villalobos-Leal M, Antaramián A, Riesgo-Escovar J, Hernández-Muñoz R, Díaz-Muñoz M. | 05/31/2010 |
| data support a model where InsP(3)R activity in non-overlapping neuronal domains independently rescues larval itpr phenotypes by non-cell autonomous mechanisms | Inositol 1,4,5- trisphosphate receptor function in Drosophila insulin producing cells.
Agrawal N, Padmanabhan N, Hasan G., Free PMC Article | 01/25/2010 |
| Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene exhibit delays in molting while stronger alleles are also larval lethal. There is a critical period for itpr gene function in second instar larvae. | Genetic dissection of itpr gene function reveals a vital requirement in aminergic cells of Drosophila larvae.
Joshi R, Venkatesh K, Srinivas R, Nair S, Hasan G., Free PMC Article | 01/21/2010 |
| ectopic expression of the Ka901 mutant channel in aminergic cells alters electrophysiological properties of a flight circuit and results in defective flight behavior | Ectopic expression of a Drosophila InsP(3)R channel mutant has dominant-negative effects in vivo.
Srikanth S, Banerjee S, Hasan G. | 01/21/2010 |
| Mutants of itpr, encoding inositol (1,4,5)-trisphosphate receptor (IP(3)R), attenuate response to diuretic peptides of Drosophila melanogaster renal (Malpighian) tubules | NorpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)- trisphosphate receptor in Drosophila melanogaster renal function.
Pollock VP, Radford JC, Pyne S, Hasan G, Dow JA, Davies SA. | 01/21/2010 |
| Results describe single channel properties of a point mutant (G2630S) in the pore-forming region of the Drosophila inositol (1,4,5)-trisphosphate receptor . | Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor.
Srikanth S, Wang Z, Hasan G, Bezprozvanny I. | 01/21/2010 |
| The InsP(3) receptor functions to modulate flight specifically through serotonergic interneurons. InsP(3) receptor action appears to be important for normal development of the flight circuit and its central pattern generator. | Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila.
Banerjee S, Lee J, Venkatesh K, Wu CF, Hasan G., Free PMC Article | 01/21/2010 |