| Muscle Psn gene combined with exercise contribute to healthy aging of skeletal muscle and lifespan by adaptively regulating Sirt1/PGC-1alpha and arm pathway. | Muscle Psn gene combined with exercise contribute to healthy aging of skeletal muscle and lifespan by adaptively regulating Sirt1/PGC-1α and arm pathway.
Gao YH, Wen DT, Du ZR, Wang JF, Wang SJ., Free PMC Article | 06/13/2024 |
| Psn is required for neuronal survival during aging and normal lifespan. | An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.
Kang J, Shin S, Perrimon N, Shen J., Free PMC Article | 10/21/2017 |
| findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Diseaseprecursor protein (APP) vesicles | Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.
Gunawardena S, Yang G, Goldstein LS., Free PMC Article | 03/22/2014 |
| a conserved role for presenilin in mediating copper uptake | Presenilin promotes dietary copper uptake.
Southon A, Greenough MA, Ganio G, Bush AI, Burke R, Camakaris J., Free PMC Article | 12/14/2013 |
| The interaction of Sanpodo with Presenilin, a component of the gamma-secretase complex, is required for Notch activation. | Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase.
Upadhyay A, Kandachar V, Zitserman D, Tong X, Roegiers F., Free PMC Article | 06/29/2013 |
| Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein. | Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
Singh J, Mlodzik M., Free PMC Article | 10/13/2012 |
| Loss of presenilin causes significantly decreased Notch signaling and neuron apoptosis and increased cytoplasm calcium. | [Advances on Drosophila presenilin gene].
Zhang Y, Zheng ZZ, Ge J, Zhang HY, Huang YW, Song HS. | 01/28/2012 |
| Psn regulates CBP levels in the adult fly brain in a manner that is independent of Notch signaling | Presenilin controls CBP levels in the adult Drosophila central nervous system.
Boyles RS, Lantz KM, Poertner S, Georges SJ, Andres AJ., Free PMC Article | 07/9/2011 |
| loss of ept alters nuclear cell cycle control in developing imaginal discs and the DaPKC, presenilin, and rbf1 genes as modifiers of molecular and cellular phenotypes that result from loss of ept | Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors.
Gilbert MM, Robinson BS, Moberg KH., Free PMC Article | 02/8/2010 |
| presenilin plays a role in regulating intracellular calcium stores | Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin.
Michno K, Knight D, Campusano JM, van de Hoef D, Boulianne GL., Free PMC Article | 02/8/2010 |
| Results demonstrate that 53 of the modifiers genetically interacted with APP, and characterization of these genes may provide valuable insights into Presenilin function in development and disease. | Identifying genes that interact with Drosophila presenilin and amyloid precursor protein.
van de Hoef DL, Hughes J, Livne-Bar I, Garza D, Konsolaki M, Boulianne GL. | 01/21/2010 |
| Study shows that Drosophila Ubiquilin (Ubqn) binds to Drosophila Presenilin (Psn), and that loss of ubqn function suppresses phenotypes that arise from loss of psn function in vivo. | ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila.
Ganguly A, Feldman RM, Guo M. | 01/21/2010 |
| evidence of learning and synaptic defects in a Drosophila psn mutant and strongly suggest a presynaptic role for presenilin in normal neuronal function. | Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant.
Knight D, Iliadi K, Charlton MP, Atwood HL, Boulianne GL. | 01/21/2010 |
| Drosophila PS (Psn) protein undergoes endoproteolytic cleavage and forms a stable high molecular weight (HMW) complex | The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.
Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. | 01/21/2010 |
| presenilin, nicastrin, APH-1, and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes | Gamma-secretase is a functional component of phagosomes.
Jutras I, Laplante A, Boulais J, Brunet S, Thinakaran G, Desjardins M. | 01/21/2010 |
| APH-1 stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex. | The role of presenilin cofactors in the gamma-secretase complex.
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. | 01/21/2010 |
| specific diaspartyl groups within the presenilin catalytic core of gamma-secretase mediate the cleavage of different substrates | Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
Cervantes S, Saura CA, Pomares E, Gonzàlez-Duarte R, Marfany G. | 01/21/2010 |
| Psn familial Alzheimer's disease mutant activities were tightly linked to their age-of-onset values, providing evidence that disease severity in humans primarily reflects differences in PS mutant lesions. | Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila.
Seidner GA, Ye Y, Faraday MM, Alvord WG, Fortini ME. | 01/21/2010 |