| Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway. | Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Zhang YR, Liu SM, Chen Y, Zhang LS, Ji DR, Zhao J, Yu YR, Jia MZ, Tang CS, Huang W, Zhou YB, Chai SB, Qi YF. | 11/29/2023 |
| Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1alpha in Cardiac Fibrosis. | Intermedin(1-53) Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis.
Zhang LS, Zhang JS, Hou YL, Lu WW, Ni XQ, Lin F, Liu XY, Wang XJ, Yu YR, Jia MZ, Tang CS, Han L, Chai SB, Qi YF. | 06/18/2022 |
| Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats. | Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats.
Wang Y, Mi Y, Tian J, Qiao X, Su X, Kang J, Wu Z, Wang G, Zhou X, Zhou Y, Li R., Free PMC Article | 08/28/2021 |
| Intermedin protects thapsigargininduced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca(2+)ATPase. | Intermedin protects thapsigargin‑induced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca(2+)‑ATPase.
Li Z, Guo J, Bian Y, Zhang M., Free PMC Article | 05/8/2021 |
| Intermedin could be a potential candidate treatment for renal fibrosis. | The protective role of intermedin in promoting angiogenesis during renal fibrosis.
Dong H, Zhou Y, Wang Y, Zhou Q, Zhang Y, Gan X, Luo Y, Li R. | 02/9/2019 |
| Study shows that intermedin has a similar effect as 3-methyladenine, can reduce pathological neuronal injury and protect the brain against cerebral ischemia/reperfusion injury in rats by attenuating the effects of autophagy. Our findings provide evidence for intermedin's protective effects in relation to ischemic cerebrovascular diseases. | Effects of intermedin on autophagy in cerebral ischemia/reperfusion injury.
Wang M, Wang J, Liu Z, Guo X, Wang N, Jia N, Zhang Y, Yuan J. | 09/8/2018 |
| Intermedin attenuated neointima formation in the rat model of carotid-artery balloon injury. IMD protection may be mediated by maintaining a vascular smooth muscle cell contractile phenotype via the cAMP/PKA pathway. | Intermedin reduces neointima formation by regulating vascular smooth muscle cell phenotype via cAMP/PKA pathway.
Zhu Q, Ni XQ, Lu WW, Zhang JS, Ren JL, Wu D, Chen Y, Zhang LS, Yu YR, Tang CS, Qi YF. | 06/30/2018 |
| Results indicate that intermedin exerts anti-oxidant effects by inhibition of Nox4, and the effect can be mediated by cAMP-PKA pathway in unilateral ureteral obstruction induced renal fibrosis. | Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms.
Qiao X, Wang L, Wang Y, Su X, Qi Y, Fan Y, Peng Z., Free PMC Article | 04/21/2018 |
| Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP. | Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.
Soultanova A, Mikulski Z, Pfeil U, Grau V, Kummer W., Free PMC Article | 05/20/2017 |
| Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia. | Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.
Meng Q, Shi D, Feng J, Su Y, Long Y, He S, Wang S, Wang Y, Zhang X, Chen X. | 12/17/2016 |
| Intermedin plays a protective role in renal fibrosis via its antioxidant effects. | Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction.
Qiao X, Wang L, Wang Y, Zhao N, Zhang R, Han W, Peng Z. | 04/16/2016 |
| These findings are the first direct evidence that IMD protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase. | Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase.
Lu WW, Zhao L, Zhang JS, Hou YL, Yu YR, Jia MZ, Tang CS, Qi YF. | 04/9/2016 |
| ADM2-like immunoreactivity is localized in granulosa cells, blood vessels, oocytes, cumulous oophorus, and corpus luteum of pregnant ovaries, suggesting a potential role for ADM2 in the ovary | Adrenomedullin2 (ADM2)/intermedin (IMD) in rat ovary: changes in estrous cycle and pregnancy and its role in ovulation and steroidogenesis.
Chauhan M, Balakrishnan M, Blesson CS, Yallampalli C., Free PMC Article | 10/24/2015 |
| TSH induced AM2/IMD expression in the thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries. | Induction of adrenomedullin 2/intermedin expression by thyroid stimulating hormone in thyroid.
Nagasaki S, Fukui M, Asano S, Ono K, Miki Y, Araki S, Isobe M, Nakashima N, Takahashi K, Sasano H, Sato J. | 05/16/2015 |
| Suggest intermedin protects against diabetic ischemic heart disease by reducing oxidative stress, inflammation, and apoptosis. | Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats.
Li H, Bian Y, Zhang N, Guo J, Wang C, Lau WB, Xiao C., Free PMC Article | 04/4/2015 |
| Intermedin in the paraventricular nucleus attenuates cardiac sympathetic afferent reflex in chronic heart failure rats | Intermedin in the paraventricular nucleus attenuates cardiac sympathetic afferent reflex in chronic heart failure rats.
Gan XB, Sun HJ, Chen D, Zhang LL, Zhou H, Chen LY, Zhou YB., Free PMC Article | 12/6/2014 |
| These data indicate that IMD in the paraventricular nucleus of hypothalamus inhibits cardiac sympathetic afferent reflex via adrenomedullin receptor, and both nitric oxide and gamma-amino butyric acid are involve in the effect. | Cardiac sympathetic afferent reflex response to intermedin microinjection into paraventricular nucleus is mediated by nitric oxide and γ-amino butyric acid in hypertensive rats.
Zhou H, Sun HJ, Chang JR, Ding L, Gao Q, Tang CS, Zhu GQ, Zhou YB. | 11/29/2014 |
| the gene expression of IMD, its receptor components and its protein localization in the testes | Intermedin attenuates LPS-induced inflammation in the rat testis.
Li L, Ma P, Liu Y, Huang C, O WS, Tang F, Zhang JV., Free PMC Article | 10/4/2014 |
| These results indicate that IMD in the paraventricular nucleus inhibits sympathetic activity and attenuates hypertension in 2K1C rats. | Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats.
Zhou YB, Sun HJ, Chen D, Liu TY, Han Y, Wang JJ, Tang CS, Kang YM, Zhu GQ. | 03/8/2014 |
| IMD and gene expression of its receptor components are differentially regulated in the uterus during the estrous cycle. | Intermedin in rat uterus: changes in gene expression and peptide levels across the estrous cycle and its effects on uterine contraction.
Wong CW, O WS, Tang F., Free PMC Article | 12/21/2013 |
| In conclusion, intermedin1-53 attenuated vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress through cyclic adenosine monophosphate/protein kinase A pathway. | Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway.
Chang JR, Duan XH, Zhang BH, Teng X, Zhou YB, Liu Y, Yu YR, Zhu Y, Tang CS, Qi YF. | 11/30/2013 |
| the downregulation of IMD at early stage of reperfusion might augment myocardium injury. | Downregulation of endogenous intermedin augmented myocardial injury in rats with ischemia/reperfusion.
Teng X, Bian Y, Cai Y, Duan X, Yuan F, Du J, Wu W, Wang X, Tang C, Qi Y. | 09/28/2013 |
| This is the first report to demonstrate opposite myocardial action of IMD(1-47) between normal and pressure-overloaded myocardium, suggesting a potential stimulatory effect of IMD(1-47) on cardiac function during heart disease. | Reverse myocardial effects of intermedin in pressure-overloaded hearts: role of endothelial nitric oxide synthase activity.
Pires AL, Pinho M, Alves BS, Pinho S, Sena C, Seica RM, Leite-Moreira AF., Free PMC Article | 08/3/2013 |
| The expression of IMD/ADM2 peptides in plasma, right ventricular and pulmonary tissues are different in the early-middle pathological stage of pulmonary hypertension induced by two-week hypoxia in rats. | [Effect of hypoxia on the expressions of intermedin/ adrenomedullin2 in plasma and the tissues of heart and lung in rats].
Gong YS, Zhang L, Guo YM, Hu LG, Mao SZ, Fan XF, Huang P, Hong L. | 10/6/2012 |
| The level of IMD/ADM2 increases in rats with chronic hypoxia-induced pulmonary hypertension. | [Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension].
Gong YS, Fan XF, Wu XM, Hu LG, Tang CS, Pang YZ, Qi YF. | 08/25/2012 |