| LIMK2 Is a Novel Prognostic Biomarker and Correlates With Tumor Immune Cell Infiltration in Lung Squamous Cell Carcinoma. | LIMK2 Is a Novel Prognostic Biomarker and Correlates With Tumor Immune Cell Infiltration in Lung Squamous Cell Carcinoma.
Su Y, Xu B, Shen Q, Lei Z, Zhang W, Hu T., Free PMC Article | 05/7/2022 |
| The Diagnostic and Prognostic Value of LIMK1/2: A Pan-Cancer Analysis. | The Diagnostic and Prognostic Value of LIMK1/2: A Pan-Cancer Analysis.
Li J, Liu Y, Zheng L. | 02/12/2022 |
| Involvement of LIMK2 in actin cytoskeleton remodeling during the definitive endoderm differentiation. | Involvement of LIMK2 in actin cytoskeleton remodeling during the definitive endoderm differentiation.
He Y, Zhang L, He Y, Yu H, Li S, Li Q. | 12/25/2021 |
| Negative cross talk between LIMK2 and PTEN promotes castration resistant prostate cancer pathogenesis in cells and in vivo. | Negative cross talk between LIMK2 and PTEN promotes castration resistant prostate cancer pathogenesis in cells and in vivo.
Nikhil K, Kamra M, Raza A, Shah K., Free PMC Article | 05/1/2021 |
| NUDT21 inhibits bladder cancer progression through ANXA2 and LIMK2 by alternative polyadenylation. | NUDT21 inhibits bladder cancer progression through ANXA2 and LIMK2 by alternative polyadenylation.
Xiong M, Chen L, Zhou L, Ding Y, Kazobinka G, Chen Z, Hou T., Free PMC Article | 09/19/2020 |
| It has been found that LIMK1/LIMK2 is critical for GPER activation-induced breast cancer cell migration. | GPER stabilizes F-actin cytoskeleton and activates TAZ via PLCβ-PKC and Rho/ROCK-LIMK-Cofilin pathway.
Wang Z, Sun L, Liang S, Liu ZC, Zhao ZY, Yang J, Wang D, Yang DQ. | 07/11/2020 |
| LIMK1and LIMK2 expression status is associated with glioblastoma (GBM) grade and poor prognosis. Simultaneous knockdown of both isoforms strongly reduced the invasive motility of continuous culture models and human GBM tumor-initiating cells. LIMK1/2 functionally regulated cell invasiveness, in part, by disrupting polarized cell motility under confinement and cell chemotaxis. | Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion.
Chen J, Ananthanarayanan B, Springer KS, Wolf KJ, Sheyman SM, Tran VD, Kumar S., Free PMC Article | 06/20/2020 |
| LIM domain kinase 2 isoform LIMK2-1 (LIMK2-1) has a protein phosphatase 1 (PP1) inhibitory domain at its C-terminus which its two isoenzymes LIMK2a and LIMK2b do not. | LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b.
Vallée B, Cuberos H, Doudeau M, Godin F, Gosset D, Vourc'h P, Andres CR, Bénédetti H. | 06/8/2019 |
| Analysis localized LIMK2 SNP rs2073859 (G-to-A allele) within the microRNA-135a binding region and revealed lower LIMK2 G allele expression. The frequency of A genotypes was higher in the bladder cancer (BC) group than normal controls and correlated with risks of higher grade and stage BC. LIMK2 may function as an oncogene in human BC, while allele-specific regulation by microRNA-135a may influence disease risk. | LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA-135a binding site affects bladder cancer risk.
Wang W, Yang C, Nie H, Qiu X, Zhang L, Xiao Y, Zhou W, Zeng Q, Zhang X, Wu Y, Liu J, Ying M., Free PMC Article | 06/8/2019 |
| Compared to the other LIMK2 isoforms, LIMK2-1 contains a supplementary C-terminal phosphatase 1 inhibitory domain (PP1i). This isoform was hominidae-specific and showed that it was expressed in human fetal brain and faintly in adult brain. An association of a rare missense variant in the PP1i domain was found in patients with sporadic non-syndromic intellectual disability. | LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability.
Tastet J, Cuberos H, Vallée B, Toutain A, Raynaud M, Marouillat S, Thépault RA, Laumonnier F, Bonnet-Brilhault F, Vourc'h P, Andres CR, Bénédetti H. | 03/16/2019 |
| rs4141404:A>C(LIMK2) may be a marker of risk of grade 2/3 paclitaxel-induced peripheral sensory neuropathy. | Single Nucleotide Polymorphisms of Paclitaxel-induced Peripheral Sensory Neuropathy in Chinese Han Population.
Dou XL, Mai YL, Sun Z, Wang YY, Shao YJ, Cheng YJ, Zhou N, Luo F, Zhang B, Bai CM, Ma SQ. | 02/16/2019 |
| In turn, LIMK1 and LIMK2 are required for MT1-MMP-dependent matrix degradation and cell invasion in a three-dimensional type I collagen environment. | LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.
Lagoutte E, Villeneuve C, Lafanechère L, Wells CM, Jones GE, Chavrier P, Rossé C., Free PMC Article | 01/20/2018 |
| High LIMK2 expression is associated with alcoholic hepatitis. | The role of the IL-8 signaling pathway in the infiltration of granulocytes into the livers of patients with alcoholic hepatitis.
French SW, Mendoza AS, Afifiyan N, Tillman B, Vitocruz E, French BA. | 11/26/2017 |
| these results suggested that TUG1 mediates cell growth and chemoresistance of SCLC by regulating LIMK2b via EZH2. | Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2.
Niu Y, Ma F, Huang W, Fang S, Li M, Wei T, Guo L., Free PMC Article | 07/29/2017 |
| LIMK2 (rs149034313) is associated with Behcet's disease. The LIMK2 association is a missense variant with predicted protein damage that may influence functional interactions with proteins involved in cytoskeletal regulation by Rho GTPase, inflammation mediated by chemokine and cytokine signaling pathways, T cell activation, and angiogenesis. | Whole Exome Sequencing Identifies Rare Protein-Coding Variants in Behçet's Disease.
Ognenovski M, Renauer P, Gensterblum E, Kötter I, Xenitidis T, Henes JC, Casali B, Salvarani C, Direskeneli H, Kaufman KM, Sawalha AH. | 07/8/2017 |
| We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients. | Evidence for elevated (LIMK2 and CFL1) and suppressed (ICAM1, EZR, MAP2K2, and NOS3) gene expressions in metabolic syndrome.
Tabur S, Oztuzcu S, Oguz E, Demiryürek S, Dagli H, Alasehirli B, Ozkaya M, Demiryürek AT. | 07/1/2017 |
| This study showed that LIMK2 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. | Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.
Datta D, Arion D, Corradi JP, Lewis DA., Free PMC Article | 08/13/2016 |
| Actin remodelling factor LIMK2 is a key player in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. | Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
Kim J, Jo H, Hong H, Kim MH, Kim JM, Lee JK, Heo WD, Kim J. | 04/9/2016 |
| Results show that in addition to a potential role in promoting metastasis, changes in LIMK1 and LIMK2 expression and/or activity might contribute to AR function in prostate cancer via regulation of microtubule cytoskeletal dynamics. | Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation.
Mardilovich K, Gabrielsen M, McGarry L, Orange C, Patel R, Shanks E, Edwards J, Olson MF., Free PMC Article | 10/3/2015 |
| results highlight the exciting possibility of combining specific LIMK2 inhibitors with anticancer drugs in the treatment of multi-drug resistant cancers | LIMK2 mediates resistance to chemotherapeutic drugs in neuroblastoma cells through regulation of drug-induced cell cycle arrest.
Gamell C, Schofield AV, Suryadinata R, Sarcevic B, Bernard O., Free PMC Article | 06/21/2014 |
| LIMK2 expression was reduced in intestinal tumours of cancer-prone mice and in human colorectal cancer cell lines and tumours. LIMK2 expression progressively decreased with advancing stage of colorectal cancer. | Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.
Lourenço FC, Munro J, Brown J, Cordero J, Stefanatos R, Strathdee K, Orange C, Feller SM, Sansom OJ, Vidal M, Murray GI, Olson MF., Free PMC Article | 04/19/2014 |
| Overexpression of LIMK2 is associated with breast cancer growth and invasiveness. | LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice.
Li R, Doherty J, Antonipillai J, Chen S, Devlin M, Visser K, Baell J, Street I, Anderson RL, Bernard O. | 06/15/2013 |
| Nf1/LIMK2 interaction and inhibition allows to directly connect neurofibromatosis type I to actin cytoskeleton remodeling. | Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.
Vallée B, Doudeau M, Godin F, Gombault A, Tchalikian A, de Tauzia ML, Bénédetti H., Free PMC Article | 04/13/2013 |
| A novel activity of Rho in promoting a complex between fascin-1 and LIMK1/2 that modulates the interaction of fascin-1 with actin, was identified. | A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.
Jayo A, Parsons M, Adams JC., Free PMC Article | 03/16/2013 |
| LIMK2 is a key regulator that acts through different substrates to provide functional links between the actin cytoskeleton and spindle dynamics. | TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.
Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT, Koh CG. | 02/16/2013 |