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    LIF LIF interleukin 6 family cytokine [ Homo sapiens (human) ]

    Gene ID: 3976, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.

    Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.
    Xie H, Jiang Y, Xiang Y, Wu B, Zhao J, Huang R, Wang M, Wang Y, Liu J, Wu D, Tian D, Bian E.,

    09/11/2024
    Cancer-associated fibroblasts promote the malignant development of lung cancer through the FOXO1 protein/LIF signaling.

    Cancer-associated fibroblasts promote the malignant development of lung cancer through the FOXO1 protein/LIF signaling.
    Shen J, Wu W, Zhang X, Xie X, Shen W, Wang Q.

    08/21/2024
    Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor.

    Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor.
    Diallo M, Pimenta C, Murtinheira F, Martins-Alves D, Pinto FR, da Costa AA, Letra-Vilela R, Martin V, Rodriguez C, Rodrigues MS, Herrera F., Free PMC Article

    07/24/2024
    The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer.

    The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer.
    Di Giorgio C, Bellini R, Lupia A, Massa C, Urbani G, Bordoni M, Marchianò S, Rosselli R, De Gregorio R, Rapacciuolo P, Sepe V, Morretta E, Monti MC, Moraca F, Cari L, Ullah KRS, Natalizi N, Graziosi L, Distrutti E, Biagioli M, Catalanotti B, Donini A, Zampella A, Fiorucci S., Free PMC Article

    06/11/2024
    Human Seminal Extracellular Vesicles Enhance Endometrial Receptivity Through Leukemia Inhibitory Factor.

    Human Seminal Extracellular Vesicles Enhance Endometrial Receptivity Through Leukemia Inhibitory Factor.
    Wang H, Lin Y, Chen R, Zhu Y, Wang H, Li S, Yu L, Zhang K, Liu Y, Jing T, Sun F.

    04/22/2024
    LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages.

    LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages.
    Guo D, Dong W, Cong Y, Liu Y, Liang Y, Ye Z, Zhang J, Zhou Y.

    02/1/2024
    MDM2-p53 mediate a miR-181c-3p/LIF axis to regulate low dose-rate radiation-induced DNA damage in human B lymphocytes.

    MDM2-p53 mediate a miR-181c-3p/LIF axis to regulate low dose-rate radiation-induced DNA damage in human B lymphocytes.
    Chen Y, Gong Y, Qin H, Wei S, Wei Y, Yu Y, Lin X, Shuai P, Wang T, Guo C, Wang Q, Li G, Meng L, Yi L.

    01/29/2024
    Interplay of "leukemia inhibitory factor receptor gene" (rs3099124) polymorphism, leukemia inhibitory factor and ovarian steroids with unexplained infertility.

    Interplay of "leukemia inhibitory factor receptor gene" (rs3099124) polymorphism, leukemia inhibitory factor and ovarian steroids with unexplained infertility.
    Ali R, Iqbal MUN, Rehman R, Khan TA.

    07/26/2023
    Relevance of leukaemia inhibitory factor to anti-melanoma differentiation-associated gene 5 antibody-positive interstitial lung disease.

    Relevance of leukaemia inhibitory factor to anti-melanoma differentiation-associated gene 5 antibody-positive interstitial lung disease.
    Ichimura Y, Ikei H, Konishi R, Zeniya M, Okai T, Nomura T, Negishi K, Okiyama N.

    06/7/2023
    The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights.

    The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights.
    Halder S, Parte S, Kshirsagar P, Muniyan S, Nair HB, Batra SK, Seshacharyulu P., Free PMC Article

    08/13/2022
    Myeloid cell-mediated targeting of LIF to dystrophic muscle causes transient increases in muscle fiber lesions by disrupting the recruitment and dispersion of macrophages in muscle.

    Myeloid cell-mediated targeting of LIF to dystrophic muscle causes transient increases in muscle fiber lesions by disrupting the recruitment and dispersion of macrophages in muscle.
    Flores I, Welc SS, Wehling-Henricks M, Tidball JG., Free PMC Article

    04/16/2022
    Endometrial injury concurrent with hysteroscopy increases the expression of Leukaemia inhibitory factor: a preliminary study.

    Endometrial injury concurrent with hysteroscopy increases the expression of Leukaemia inhibitory factor: a preliminary study.
    Ersahin SS, Ersahin A., Free PMC Article

    03/26/2022
    PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.

    PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
    Wen YC, Liu CL, Yeh HL, Chen WH, Jiang KC, Tram VTN, Hsiao M, Huang J, Chen WY, Liu YN., Free PMC Article

    03/12/2022
    Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer.

    Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer.
    Liu S, Gandler HI, Tošić I, Ye DQ, Giaccone ZT, Frank DA., Free PMC Article

    02/12/2022
    The expression and significance of leukemia inhibitory factor, interleukin-6 and vascular endothelial growth factor in Chinese patients with endometriosis.

    The expression and significance of leukemia inhibitory factor, interleukin-6 and vascular endothelial growth factor in Chinese patients with endometriosis.
    Li C, Zhao HL, Li YJ, Zhang YY, Liu HY, Feng FZ, Yan H.

    11/13/2021
    Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance.

    Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance.
    Loriot Y, Marabelle A, Guégan JP, Danlos FX, Besse B, Chaput N, Massard C, Planchard D, Robert C, Even C, Khettab M, Tselikas L, Friboulet L, André F, Nafia I, Le Loarer F, Soria JC, Bessede A, Italiano A.

    11/6/2021
    Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers.

    Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers.
    Yu S, Li Q, Wang Y, Cui Y, Yu Y, Li W, Liu F, Liu T.

    10/23/2021
    Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation.

    Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation.
    Kawazoe T, Saeki H, Oki E, Oda Y, Maehara Y, Mori M, Taniguchi K.

    10/2/2021
    Leukemia inhibitory factor: A main controller of breast cancer.

    Leukemia inhibitory factor: A main controller of breast cancer.
    Vaziri N, Shariati L, Javanmard SH.

    10/2/2021
    LIF in embryo culture medium is a predictive marker for clinical pregnancy following IVF-ET of patients with fallopian tube obstruction.

    LIF in embryo culture medium is a predictive marker for clinical pregnancy following IVF-ET of patients with fallopian tube obstruction.
    Li Z, Li R, Li X, Dai H, Han X, Wang X, Yang A.

    09/25/2021
    Association of novel stop-gained leukaemia inhibitory factor receptor gene (rs121912501) variant, leukaemia inhibitory factor and ovarian steroids with unexplained infertility among Pakistani women.

    Association of novel stop-gained leukaemia inhibitory factor receptor gene (rs121912501) variant, leukaemia inhibitory factor and ovarian steroids with unexplained infertility among Pakistani women.
    Ali R, Iqbal MUN, Rehman R, Khan TA.

    08/28/2021
    Polymorphism in the 3'-UTR of LIF but Not in the ATF6B Gene Associates with Schizophrenia Susceptibility: a Case-Control Study and In Silico Analyses.

    Polymorphism in the 3'-UTR of LIF but Not in the ATF6B Gene Associates with Schizophrenia Susceptibility: a Case-Control Study and In Silico Analyses.
    Moudi M, Sargazi S, Heidari Nia M, Saravani R, Shirvaliloo M, Shakiba M.

    08/21/2021
    Leukemia inhibitory factor is a novel biomarker to predict lymph node and distant metastasis in pancreatic cancer.

    Leukemia inhibitory factor is a novel biomarker to predict lymph node and distant metastasis in pancreatic cancer.
    Jiang W, Bai W, Li J, Liu J, Zhao K, Ren L.

    07/17/2021
    Induced Pluripotent Stem Cell-Derived Conditioned Medium Promotes Endogenous Leukemia Inhibitory Factor to Attenuate Endotoxin-Induced Acute Lung Injury.

    Induced Pluripotent Stem Cell-Derived Conditioned Medium Promotes Endogenous Leukemia Inhibitory Factor to Attenuate Endotoxin-Induced Acute Lung Injury.
    Su VY, Chiou SH, Chen WC, Yu WK, Wu HH, Chen H, Yang KY., Free PMC Article

    06/26/2021
    Impact of IFN-beta and LIF overexpression on human adipose-derived stem cells properties.

    Impact of IFN-β and LIF overexpression on human adipose-derived stem cells properties.
    Ashja-Arvan M, Dehbashi M, Eslami A, Salehi H, Yoosefi M, Ganjalikhani-Hakemi M.

    03/20/2021
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