| The Drosophila gene encoding JIG protein (CG14850) is critical for CrebA nuclear trafficking during development. | The Drosophila gene encoding JIG protein (CG14850) is critical for CrebA nuclear trafficking during development.
Bhuiyan SH, Bordet G, Bamgbose G, Tulin AV., Free PMC Article | 06/29/2023 |
| CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila. | CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.
Lin HW, Chen CC, de Belle JS, Tully T, Chiang AS., Free PMC Article | 12/25/2021 |
| CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators. | CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators.
Johnson DM, Wells MB, Fox R, Lee JS, Loganathan R, Levings D, Bastien A, Slattery M, Andrew DJ., Free PMC Article | 05/8/2021 |
| Loss of CrebA also partially suppresses mHtt effects on behavior and cell loss and restoration of CrebA can suppress Atx2 effects. Our results indicate a prominent role of Atx2 in mediating mHtt pathology, specifically via its regulation of CrebA, defining a novel molecular pathway in Huntington's disease pathogenesis. | Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons.
Xu F, Kula-Eversole E, Iwanaszko M, Lim C, Allada R., Free PMC Article | 02/1/2020 |
| Data suggest that CrebA is involved in regulation of infection tolerance in this species; expression of CrebA is regulated in the fat body upon infection; CrebA is required to survive infection and promotes tolerance of bacterial infection; CrebA deficiency leads to ER (endoplasmic reticulum) stress upon bacterial challenge. | Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster.
Troha K, Im JH, Revah J, Lazzaro BP, Buchon N, Troha K, Im JH, Revah J, Lazzaro BP, Buchon N., Free PMC Articles: PMC5812652, PMC5812652 | 06/23/2018 |
| CrebA deficiency leads to ER stress upon bacterial challenge | Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster.
Troha K, Im JH, Revah J, Lazzaro BP, Buchon N, Troha K, Im JH, Revah J, Lazzaro BP, Buchon N., Free PMC Articles: PMC5812652, PMC5812652 | 03/26/2018 |
| Drosophila CrebA directly binds the enhancers of secretory pathway genes and is both necessary and sufficient to activate expression of every secretory pathway component gene examined thus far. | The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity.
Fox RM, Hanlon CD, Andrew DJ., Free PMC Article | 12/11/2010 |
| direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP, proteasome, Drosophila inhibitor of apoptosis protein 1 (DIAP1) | Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models.
Mallik M, Lakhotia SC., Free PMC Article | 08/23/2010 |
| The CREB binding protein transcriptional cofactor is necessary and sufficient for down-regulation of DIAP1. | Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death.
Yin VP, Thummel CS, Bashirullah A., Free PMC Article | 01/21/2010 |
| CrebA activity is linked to secretory function in multiple tissues | CrebA regulates secretory activity in the Drosophila salivary gland and epidermis.
Abrams EW, Andrew DJ. | 01/21/2010 |
| cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity. | cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila.
Iijima-Ando K, Wu P, Drier EA, Iijima K, Yin JC., Free PMC Article | 01/21/2010 |
| AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila | AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila.
Sanyal S, Sandstrom DJ, Hoeffer CA, Ramaswami M. | 01/21/2010 |