| ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways. | ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways.
Xie J, Li Y, Zeng T, Fan T, Shan H, Shi G, Zhou W, Zou J, Lei X., Free PMC Article | 10/11/2024 |
| Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus. | Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus.
Seifert CT, Unverdorben L, Knabl J, Hutter S, Keckstein S, Schmoeckel E, Kessler M, Jeschke U, Mahner S, Kolben T, Ganster F., Free PMC Article | 10/2/2024 |
| Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer. | Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
Sun L, Liu R, Wu ZJ, Liu ZY, Wan AH, Yan S, Liu C, Liang H, Xiao M, You N, Lou Y, Deng Y, Bu X, Chen D, Huang J, Zhang X, Kuang DM, Wan G. | 02/26/2024 |
| Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions. | Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.
Liang Y, Wang Y, Zhu X, Cai J, Shi A, Huang J, Zhu Q, Si Y., Free PMC Article | 11/5/2022 |
| Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes. | Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes.
Fujimoto N, Akiyama M, Satoh Y, Tajima S. | 05/14/2022 |
| CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury. | CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury.
Sun X, Shen W, Li Z, Zhang W. | 01/8/2022 |
| Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7. | Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
Pham NTH, Létourneau M, Fortier M, Bégin G, Al-Abdul-Wahid MS, Pucci F, Folch B, Rooman M, Chatenet D, St-Pierre Y, Lagüe P, Calmettes C, Doucet N., Free PMC Article | 12/18/2021 |
| Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7. | Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.
Chapman JR, Liu A, Yi SS, Hernandez E, Ritorto MS, Jungbluth AA, Pulitzer M, Dogan A., Free PMC Article | 11/13/2021 |
| Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis. | Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.
Umayahara T, Shimauchi T, Iwasaki M, Sakabe JI, Aoshima M, Nakazawa S, Yatagai T, Yamaguchi H, Phadungsaksawasdi P, Kurihara K, Tokura Y., Free PMC Article | 11/6/2021 |
| Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity. | Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
Ludwig AK, Michalak M, Gabba A, Kutzner TJ, Beckwith DM, FitzGerald FG, García Caballero G, Manning JC, Kriegsmann M, Kaltner H, Murphy PV, Cudic M, Kopitz J, Gabius HJ., Free PMC Article | 10/23/2021 |
| Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression. | Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression.
St-Pierre Y., Free PMC Article | 09/25/2021 |
| Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis. | Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.
Chen HL, Lo CH, Huang CC, Lu MP, Hu PY, Chen CS, Chueh DY, Chen P, Lin TN, Lo YH, Hsiao YP, Hsu DK, Liu FT., Free PMC Article | 09/11/2021 |
| Degraded Arabinogalactans and Their Binding Properties to Cancer-Associated Human Galectins. | Degraded Arabinogalactans and Their Binding Properties to Cancer-Associated Human Galectins.
Pfeifer L, Baumann A, Petersen LM, Höger B, Beitz E, Classen B., Free PMC Article | 05/15/2021 |
| Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice. | Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice.
Menkhorst E, Zhou W, Santos LL, Delforce S, So T, Rainczuk K, Loke H, Syngelaki A, Varshney S, Williamson N, Pringle K, Young MJ, Nicolaides KH, St-Pierre Y, Dimitriadis E. | 05/1/2021 |
| Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function. | Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function.
Miller MC, Nesmelova IV, Daragan VA, Ippel H, Michalak M, Dregni A, Kaltner H, Kopitz J, Gabius HJ, Mayo KH., Free PMC Article | 02/27/2021 |
| A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis. | A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis.
Saigusa R, Yamashita T, Miura S, Hirabayashi M, Nakamura K, Miyagawa T, Fukui Y, Yoshizaki A, Sato S, Asano Y. | 10/3/2020 |
| Gal-7 knockdown attenuates TGF-beta1-induced apoptosis in bronchial epithelial cells through inactivation of JNK pathway. | Silencing of Gal-7 inhibits TGF-β(1)-induced apoptosis of human airway epithelial cells through JNK signaling pathway.
Sun X, Zhang W. | 05/23/2020 |
| Herein, the authors first revealed that Galectin-7 was one of the Tid1-interacting client proteins. An inverse association of protein expression profile between Tid1 and Galectin-7 was determined in head and neck squamous cell carcinoma patients. Low Tid1 and high Galectin-7 expression predicted poor overall survival in head and neck squamous cell carcinoma. | HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling.
Chen YS, Chang CW, Tsay YG, Huang LY, Wu YC, Cheng LH, Yang CC, Wu CH, Teo WH, Hung KF, Huang CY, Lee TC, Lo JF., Free PMC Article | 08/31/2019 |
| We further demonstrated using the NMR-based hydrogen-deuterium exchange (HDX) that lactose binding increases the exchange rates of residues located on the opposite side of the ligand-binding pocket for hGal1 and hGal8(NTD), indicative of allostery. Additionally, lactose binding induces significant stabilisation of hGal8(CTD) across the entire domain | Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen-Deuterium Exchange.
Chien CH, Ho MR, Lin CH, Hsu SD., Free PMC Article | 04/28/2018 |
| Increased O-linked N-Acetyl-glucosamine (O-GlcNAc) is responsible for reduced Gal-7 expression in cultured human keratinocytes exposed to high glucose environment. | High-glucose environment induced intracellular O-GlcNAc glycosylation and reduced galectin-7 expression in keratinocytes: Implications on impaired diabetic wound healing.
Huang SM, Wu CS, Chiu MH, Yang HJ, Chen GS, Lan CE. | 04/14/2018 |
| We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. | Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients.
Schulz H, Schmoeckel E, Kuhn C, Hofmann S, Mayr D, Mahner S, Jeschke U., Free PMC Article | 03/31/2018 |
| Data suggest that evaluation of galectin-7 could help guide postsurgical management for non-metastatic clear cell renal cell carcinoma (ccRCC). | High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma.
Wang J, Liu Y, Yang Y, Xu Z, Zhang G, Liu Z, Fu H, Wang Z, Liu H, Xu J., Free PMC Article | 01/20/2018 |
| these findings reveal the existence of a positive self-amplification pathway that regulates intracellular gal-7 expression in breast and ovarian cancer cells. | Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7.
Bibens-Laulan N, St-Pierre Y., Free PMC Article | 12/2/2017 |
| Gal-7 re-expression affects the regulation of molecular networks in cervical cancer that are involved in diverse cancer hallmarks, such as metabolism, growth control, invasion and evasion of apoptosis | Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment.
Higareda-Almaraz JC, Ruiz-Moreno JS, Klimentova J, Barbieri D, Salvador-Gallego R, Ly R, Valtierra-Gutierrez IA, Dinsart C, Rabinovich GA, Stulik J, Rösl F, Rincon-Orozco B., Free PMC Article | 10/21/2017 |
| Measurement of scGal-7 content in tape-stripped samples was useful for the evaluation of the skin barrier function in dry skin conditions such as AD | Galectin-7 in the stratum corneum: a biomarker of the skin barrier function.
Niiyama S, Yoshino T, Yasuda C, Yu X, Izumi R, Ishiwatari S, Matsukuma S, Mukai H. | 04/22/2017 |