| A gradient of Wnt activity positions the neurosensory domains of the inner ear. | A gradient of Wnt activity positions the neurosensory domains of the inner ear.
Żak M, Daudet N., Free PMC Article | 12/11/2021 |
| Neural-fated self-renewing cells regulated by Sox2 during secondary neurulation in chicken tail bud. | Neural-fated self-renewing cells regulated by Sox2 during secondary neurulation in chicken tail bud.
Kawachi T, Shimokita E, Kudo R, Tadokoro R, Takahashi Y. | 12/19/2020 |
| SNP g.32828A>G of RB1 is an obesity-associated variant that directly affects binding with NF-KB and SOX2, leading to changes in RB1 expression which in turn may influence chicken abdominal fat deposition. | Functional Intronic Variant in the Retinoblastoma 1 Gene Underlies Broiler Chicken Adiposity by Altering Nuclear Factor-kB and SRY-Related HMG Box Protein 2 Binding Sites.
Cheng B, Zhang H, Liu C, Chen X, Chen Y, Sun Y, Leng L, Li Y, Luan P, Li H. | 10/5/2019 |
| Sox2 participates in the regulation of Cped1. | Cped1 promotes chicken SSCs formation with the aid of histone acetylation and transcription factor Sox2.
Zhang C, Wang F, Zuo Q, Sun C, Jin J, Li T, Wang M, Zhao R, Yu X, Sun H, Zhang Y, Chen G, Li B., Free PMC Article | 06/29/2019 |
| Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. | Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation.
Panaliappan TK, Wittmann W, Jidigam VK, Mercurio S, Bertolini JA, Sghari S, Bose R, Patthey C, Nicolis SK, Gunhaga L., Free PMC Article | 04/14/2018 |
| Data obtained in this study deciphers a novel role of hindbrain boundaries as repetitive pools of neural stem/progenitor cells, which provide proliferating progenitors and differentiating neurons in a Sox2-dependent regulation. | A new role of hindbrain boundaries as pools of neural stem/progenitor cells regulated by Sox2.
Peretz Y, Eren N, Kohl A, Hen G, Yaniv K, Weisinger K, Cinnamon Y, Sela-Donenfeld D., Free PMC Article | 10/21/2017 |
| Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system. | Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system.
Lee KE, Seo J, Shin J, Ji EH, Roh J, Kim JY, Sun W, Muhr J, Lee S, Kim J., Free PMC Article | 04/19/2014 |
| Data indicate that cultured embryonic stem cells (cESCs) expressed pluripotency transcription factors, POUV, Sox-2, Nanog and Lin28 exhibited typical characteristics of pluripotency, even after six generations of rapid doubling. | Four recombinant pluripotency transcriptional factors containing a protein transduction domain maintained the in vitro pluripotency of chicken embryonic stem cells.
Yu M, Lian S, Han H, Yu K, Li G, Lian Z, Li N. | 07/6/2013 |
| The results of this study suggested that high levels of Sox2 inhibit progression of neurogenesis in the developing inner ear | Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by neurogenin1 and neurod1.
Evsen L, Sugahara S, Uchikawa M, Kondoh H, Wu DK., Free PMC Article | 04/27/2013 |
| Sensory competence is established early in otic development through the activation of Atoh1 by Sox2, however, hair cell differentiation is prevented until later stages by the parallel activation of negative regulators of Atoh1 function. | The prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1.
Neves J, Uchikawa M, Bigas A, Giraldez F., Free PMC Article | 06/9/2012 |
| suggest that the prosensory function of Jag1 resides in its ability to generate discrete domains of Notch activity that maintain Sox2 expression within restricted areas of an extended neurosensory-competent domain | Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification.
Neves J, Parada C, Chamizo M, Giráldez F. | 03/5/2011 |
| A 110-bp minimal essential sequence of SOX2 regulatory enhancer element N-4 is identified, containing 9 regulatory elements involved in activation in cephalic ectoderm, in CNS and in mesencephalon. | Regulation of Sox2 in the pre-placodal cephalic ectoderm and central nervous system by enhancer N-4.
Saigou Y, Kamimura Y, Inoue M, Kondoh H, Uchikawa M. | 01/1/2011 |
| More mature neurogenic progenitor cells express Sox2 and the bHLH transcription factor, E2A, and not Delta1 | Progenitor cell maturation in the developing vertebrate retina.
Yang HJ, Silva AO, Koyano-Nakagawa N, McLoon SC. | 02/15/2010 |
| Sox2 can initiate a reprogramming of retinal pigment epithelium cells to differentiate toward retinal neurons and may engage bFGF during the process. | Reprogramming retinal pigment epithelium to differentiate toward retinal neurons with Sox2.
Ma W, Yan RT, Li X, Wang SZ., Free PMC Article | 01/21/2010 |
| Sox2 and SF1 may mediate basal nestin expression in undifferentiated cells, whereas Sox2, Brn1, and Brn2 bind to the enhancer in neural progenitor cells. | Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.
Jin Z, Liu L, Bian W, Chen Y, Xu G, Cheng L, Jing N., Free PMC Article | 01/21/2010 |
| interactions between three coiled-coil domain proteins (ERNI, Geminin, and BERT), the heterochromatin proteins HP1alpha and HP1gamma acting as repressors, and the chromatin-remodeling enzyme Brm acting as activator control the N2 enhancer. | A mechanism regulating the onset of Sox2 expression in the embryonic neural plate.
Papanayotou C, Mey A, Birot AM, Saka Y, Boast S, Smith JC, Samarut J, Stern CD., Free PMC Article | 01/21/2010 |
| The present study shows that SOX2 protein is expressed in a spatially and temporally restricted manner throughout development of the chick inner ear. | Differential expression of Sox2 and Sox3 in neuronal and sensory progenitors of the developing inner ear of the chick.
Neves J, Kamaid A, Alsina B, Giraldez F. | 01/21/2010 |
| Wnt and FGF signals converge to activate Sox2 expression through the enhancer N-1c, revealing the direct involvement of the Wnt signal in the initiation of neural plate development. | Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1.
Takemoto T, Uchikawa M, Kamachi Y, Kondoh H. | 01/21/2010 |
| inhibits neural crest formation as a transcriptional activator and regulates proliferation and differentiation in developing peripheral nervous system | Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development.
Wakamatsu Y, Endo Y, Osumi N, Weston JA. | 01/21/2010 |
| involvement of Group B1 Sox functions in N-cadherin regulation via enhancers having activity in the early CNS and/or sensory placodes but with unique spatiotemporal specificities | Multiple N-cadherin enhancers identified by systematic functional screening indicate its Group B1 SOX-dependent regulation in neural and placodal development.
Matsumata M, Uchikawa M, Kamachi Y, Kondoh H. | 01/21/2010 |