| RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia. | RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia.
Song G, Jin F. | 08/20/2022 |
| miR-497 promotes the migration and invasion of human medulloblast Daoy cell line through targeted regulation of ARHGDIA in vitro. | miR-497 promotes the migration and invasion of human medulloblast Daoy cell line through targeted regulation of ARHGDIA in vitro.
Zhou KY, Zhou YH, Ji HL, Luo YK. | 03/26/2022 |
| Downregulation of miR4835p inhibits TGFbeta1induced EMT by targeting RhoGDI1 in pulmonary fibrosis. | Downregulation of miR‑483‑5p inhibits TGF‑β1‑induced EMT by targeting RhoGDI1 in pulmonary fibrosis.
Huang G, Zhang J, Qing G, Liu D, Wang X, Chen Y, Wu Y, Li Y, Guo S., Free PMC Article | 11/13/2021 |
| connects the interaction between RhoGDI1 and ephrinB1 to the promotion of cancer cell behavior associated with tumor progression | EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.
Cho HJ, Hwang YS, Yoon J, Lee M, Lee HG, Daar IO., Free PMC Article | 03/9/2019 |
| Results indicate that protein phosphatase 1B (PPM1B) negatively regulates cancer cell motility and invasiveness through dephosphorylating Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1). | Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion.
Cho HJ, Kim JT, Lee SJ, Hwang YS, Park SY, Kim BY, Yoo J, Hong KS, Min JK, Lee CH, Lim JS, Yoon SR, Choi I, Choe YK, Lee HG. | 10/27/2018 |
| RhoGDIalpha is involved in the maintenance of glioma stem cells | RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells.
Wu F, Hu P, Li D, Hu Y, Qi Y, Yin B, Jiang T, Yuan J, Han W, Peng X., Free PMC Article | 03/24/2018 |
| analysis of the Kindlin-2-RhoGDIalpha-Rac1 signaling axis that is critical for regulation of podocyte structure and function in vivo | Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury.
Sun Y, Guo C, Ma P, Lai Y, Yang F, Cai J, Cheng Z, Zhang K, Liu Z, Tian Y, Sheng Y, Tian R, Deng Y, Xiao G, Wu C., Free PMC Article | 12/30/2017 |
| Data suggest that the interaction between PCBP2 and the 3'UTR of the ARHGDIA mRNA may induce a local change in RNA structure that favors subsequent binding of miR-151-5p and miR-16, thus leading to the suppression of ARHGDIA expression. | Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.
Lin X, Yang B, Liu W, Tan X, Wu F, Hu P, Jiang T, Bao Z, Yuan J, Qiang B, Peng X, Han W., Free PMC Article | 12/2/2017 |
| These molecular changes are indicative of long-term premature endothelial dysfunction and provide a mechanistic framework to the epidemiological data showing increased risk of cardiovascular disease at 0.5 Gy. | Proteome analysis of irradiated endothelial cells reveals persistent alteration in protein degradation and the RhoGDI and NO signalling pathways.
Azimzadeh O, Subramanian V, Ständer S, Merl-Pham J, Lowe D, Barjaktarovic Z, Moertl S, Raj K, Atkinson MJ, Tapio S. | 09/30/2017 |
| our results suggest that RhoGDIalpha regulate TRF1 and telomere length and may be novel prognostic biomarkers in colorectal cancer | Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer.
Huang D, Lu W, Zou S, Wang H, Jiang Y, Zhang X, Li P, Songyang Z, Wang L, Wang J, Huang J, Fang L., Free PMC Article | 09/16/2017 |
| Together, our results suggest a role for Ly-GDI in the localized regulation of Rho GTPases in platelets and hypothesize a link between the PKC and Rho GTPase signaling systems in platelet function. | Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach.
Ngo AT, Thierheimer ML, Babur Ö, Rocheleau AD, Huang T, Pang J, Rigg RA, Mitrugno A, Theodorescu D, Burchard J, Nan X, Demir E, McCarty OJ, Aslan JE., Free PMC Article | 06/10/2017 |
| MiR-25 is activated by the WNT/beta-catenin signaling pathway, and exerts its pro-metastatic function by directly inhibiting the Rho GDP dissociation inhibitor alpha (RhoGDI1). Downregulation of RhoGDI1 enhances expression of Snail, thereby promoting EMT. | MiR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1.
Wang C, Wang X, Su Z, Fei H, Liu X, Pan Q., Free PMC Article | 10/29/2016 |
| RIP2 and RhoGDI bind to p75(NTR) death domain at partially overlapping epitopes with over 100-fold difference in affinity, revealing the mechanism by which RIP2 recruitment displaces RhoGDI upon ligand binding. | Structural basis of death domain signaling in the p75 neurotrophin receptor.
Lin Z, Tann JY, Goh ET, Kelly C, Lim KB, Gao JF, Ibanez CF., Free PMC Article | 10/8/2016 |
| Downregulation of RhoGDI could be a critical mechanism of breast tumor development, which may involve the hyperactivation of Rho GTPases and upregulation of COX-2 activity. | RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression.
Bozza WP, Zhang Y, Hallett K, Rivera Rosado LA, Zhang B., Free PMC Article | 08/13/2016 |
| This study showed that ARHGD1A messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. | Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.
Datta D, Arion D, Corradi JP, Lewis DA., Free PMC Article | 08/13/2016 |
| RHOGDI alpha acetylation interferes with Rho signaling, resulting in alteration of cellular filamentous actin. | Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation.
Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Zienert AY, Meyer-Teschendorf K, Praefcke GJK, Nolte H, Krüger M, Schacherl M, Baumann U, James LC, Chin JW, Lammers M., Free PMC Article | 08/6/2016 |
| the present study has identified loss of ARHGDIA contributed to the processes of hepatic tumorigenesis, in particular invasion and metastasis | Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells.
Liang L, Li Q, Huang LY, Li DW, Wang YW, Li XX, Cai SJ. | 01/31/2015 |
| Results identify a critical role for 14-3-3tau in promoting breast cancer metastasis, in part through binding to and inhibition of RhoGDIalpha, a negative regulator of Rho GTPases and a metastasis suppressor. | 14-3-3τ promotes breast cancer invasion and metastasis by inhibiting RhoGDIα.
Xiao Y, Lin VY, Ke S, Lin GE, Lin FT, Lin WC., Free PMC Article | 12/20/2014 |
| new mechanistic insights into the understanding of essential role of SUMOylation at Lys-138 in RhoGDIalpha's biological function. | SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells.
Cao Z, Li X, Li J, Kang B, Chen J, Luo W, Huang C., Free PMC Article | 10/18/2014 |
| By directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM). | miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.
Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Lin J, Li M, Ma W, Luo S, Bai X. | 08/30/2014 |
| A significant trend was identified between loss of RhoGDI expression in hepatocellular carcinoma and worsening clinical prognosis. | Loss of RhoGDI is a novel independent prognostic factor in hepatocellular carcinoma.
Li W, Wang H, Jin X, Zhao L., Free PMC Article | 07/19/2014 |
| Our findings suggest that RhoGDI overexpression is a predictor of distant metastasis and plays an important role in the progression of hepatocellular carcinoma | Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma.
Wang H, Wang B, Liao Q, An H, Li W, Jin X, Cui S, Zhao L. | 03/29/2014 |
| the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation. | TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite outgrowth.
Lu Y, Liu X, Zhou J, Huang A, Zhou J, He C., Free PMC Article | 02/8/2014 |
| It was found that the silencing of RhoGDIalpha in MCF7 and MDA-MB-231 cells significantly increased migration and invasion of these cells into the lower surface of porous membrane of the transwell chambers. | Downregulation of RhoGDIα increased migration and invasion of ER (+) MCF7 and ER (-) MDA-MB-231 breast cancer cells.
Hooshmand S, Ghaderi A, Yusoff K, Karrupiah T, Rosli R, Mojtahedi Z., Free PMC Article | 02/8/2014 |
| GDIalpha suppresses AR signaling through inhibition of AR expression, nuclear translocation, and recruitment to androgen-responsive genes. GDIalpha regulatory pathway may play a critical role in regulating AR signaling and prostate cancer growth and progression. | RhoGDIα downregulates androgen receptor signaling in prostate cancer cells.
Zhu Y, Liu C, Tummala R, Nadiminty N, Lou W, Gao AC., Free PMC Article | 11/30/2013 |