| Screen for novel regulators of synapse morphogenesis at the larval neuromuscular junction in Drosophila identified miR-34 as conserved synapse-regulatory miRNA and junctional receptor CNTNAP4/Neurexin-IV (Nrx-IV) and the membrane cytoskeletal effector Adducin/Hu-li tai shao (Hts) as proteins whose synaptic expression is restricted by miR-34. | The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells.
McNeill EM, Warinner C, Alkins S, Taylor A, Heggeness H, DeLuca TF, Fulga TA, Wall DP, Griffith LC, Van Vactor D., Free PMC Article | 05/9/2020 |
| DNrx promotes ephrin clustering and reveals that ephrin/Eph signaling from adjacent L4 neurons restricts axonal branches of L4 neurons in columns. | Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering.
Liu L, Tian Y, Zhang XY, Zhang X, Li T, Xie W, Han J. | 06/24/2017 |
| Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation in part by restricting the expression of the cell adhesion molecule Neurexin.[Tcf4] | Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.
D'Rozario M, Zhang T, Waddell EA, Zhang Y, Sahin C, Sharoni M, Hu T, Nayal M, Kutty K, Liebl F, Hu W, Marenda DR., Free PMC Article | 12/31/2016 |
| Neurexin mediates retinoid transport and subsequent rhodopsin maturation in visual function; the Drosophila homolog of alpha-neurexin is critical for fly visual function. | Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation.
Tian Y, Li T, Sun M, Wan D, Li Q, Li P, Zhang ZC, Han J, Xie W. | 03/23/2013 |
| The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. | The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity.
Rodrigues F, Thuma L, Klämbt C. | 06/9/2012 |
| The first Laminin G-EGF-Laminin G module in the extracellular region of Neurexin IV is necessary for the localization of and association with Contactin. | A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctions.
Banerjee S, Paik R, Mino RE, Blauth K, Fisher ES, Madden VJ, Fanning AS, Bhat MA., Free PMC Article | 02/18/2012 |
| Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV. | Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions.
Slováková J, Carmena A. | 05/28/2011 |
| The possibility that neurexin is present postsynaptically raises new hypotheses regarding neurexin function in synapses, and our results provide new insights into the role of neurexin in synapse development | Neurexin in embryonic Drosophila neuromuscular junctions.
Chen K, Gracheva EO, Yu SC, Sheng Q, Richmond J, Featherstone DE., Free PMC Article | 09/6/2010 |
| Nrx IV is essential for proper Robo localization and repulsive axon guidance, and is a novel interacting partner of the Slit/Robo signaling pathway. | Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance.
Banerjee S, Blauth K, Peters K, Rogers SL, Fanning AS, Bhat MA., Free PMC Article | 05/10/2010 |
| Although both Neurexin IV isoforms are able to bind Wrapper, the neuronal isoform has a higher affinity for Wrapper | Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper.
Stork T, Thomas S, Rodrigues F, Silies M, Naffin E, Wenderdel S, Klämbt C. | 01/21/2010 |
| Drosophila FERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins | Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.
Laprise P, Lau KM, Harris KP, Silva-Gagliardi NF, Paul SM, Beronja S, Beitel GJ, McGlade CJ, Tepass U. | 01/21/2010 |
| neuronal-expressed Neurexin IV and midline glial-expressed Wrapper act as heterophilic adhesion molecules that mediate multiple cellular events involved in glia-neuron interactions | Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment.
Wheeler SR, Banerjee S, Blauth K, Rogers SL, Bhat MA, Crews ST., Free PMC Article | 01/21/2010 |
| Data show that the lateral mobility of cell adhesion molecules neurexin IV, neuroglian, and contactin is highly restricted at septate junctions in Drosophila. | The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in Drosophila.
Laval M, Bel C, Faivre-Sarrailh C., Free PMC Article | 01/21/2010 |
| Loss of Nrx IV leads to defects in ommatidial morphology and integrity. | Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila.
Banerjee S, Bainton RJ, Mayer N, Beckstead R, Bhat MA., Free PMC Article | 01/21/2010 |