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    LCP1 lymphocyte cytosolic protein 1 [ Homo sapiens (human) ]

    Gene ID: 3936, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer.

    Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer.
    Giri K, Maity S, Ambatipudi K.

    10/1/2022
    Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer.

    Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer.
    Bao W, Zhu Z, Gao Y, Chen J.

    06/11/2022
    LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer.

    LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer.
    Zeng Q, Li L, Feng Z, Luo L, Xiong J, Jie Z, Cao Y, Li Z.

    10/23/2021
    The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer.

    The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer.
    Schaffner-Reckinger E, Machado RAC.

    08/28/2021
    Among the proteins found to preferentially bind clasped rather than the isolated alphaM and beta2 subunits was L-plastin (LCP1, also known as plastin-2), which binds to and maintains the inactive state of alphaMbeta2 integrin in vivo and thereby regulates leukocyte adhesion to integrin ligands under flow.

    LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.
    Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT., Free PMC Article

    01/11/2020
    LPL oxidation diminishes its actin-bundling capacity.

    Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.
    Balta E, Hardt R, Liang J, Kirchgessner H, Orlik C, Jahraus B, Hillmer S, Meuer S, Hübner K, Wabnitz GH, Samstag Y., Free PMC Article

    12/21/2019
    LCP1-positive oral squamous cell carcnome samples were correlated closely with the primary tumor size and regional lymph node metastasis.

    Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.
    Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K., Free PMC Article

    11/17/2018
    MOLP8/R cells display a very high overexpression of LCP1 gene (l-Plastin) controlled by HIF1&alpha.

    Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy.
    Bosseler M, Marani V, Broukou A, Lequeux A, Kaoma T, Schlesser V, François JH, Palissot V, Berchem GJ, Aouali N, Janji B., Free PMC Article

    10/20/2018
    these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment.

    AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin.
    Chen C, Cai Q, He W, Lam TB, Lin J, Zhao Y, Chen X, Gu P, Huang H, Xue M, Liu H, Su F, Huang J, Zheng J, Lin T., Free PMC Article

    06/9/2018
    Mutated LCP1 is a driver of chronic lymphocytic leukemia.

    Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.
    Wang L, Fan J, Francis JM, Georghiou G, Hergert S, Li S, Gambe R, Zhou CW, Yang C, Xiao S, Cin PD, Bowden M, Kotliar D, Shukla SA, Brown JR, Neuberg D, Alessi DR, Zhang CZ, Kharchenko PV, Livak KJ, Wu CJ., Free PMC Article

    06/2/2018
    AngII-dependent phosphorylation of LCP1 in cultured podocytes was mediated by the kinases ERK, p90 ribosomal S6 kinase, PKA, or PKC. LCP1 phosphorylation increased filopodia formation.

    Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes.
    Schenk LK, Möller-Kerutt A, Klosowski R, Wolters D, Schaffner-Reckinger E, Weide T, Pavenstädt H, Vollenbröker B.

    11/25/2017
    L-plastin regulates the stability of the immune synapse of naive and effector T-cells. (Review)

    L-plastin regulates the stability of the immune synapse of naive and effector T-cells.
    Wabnitz G, Balta E, Samstag Y.

    11/18/2017
    The findings support a mechanism in which miR-375 suppresses RUNX1 levels, resulting in reduced vimentin and L-plastin expression. Knockdown of RUNX1, L-plastin, and vimentin resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion.

    miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin.
    Jimenez L, Lim J, Burd B, Harris TM, Ow TJ, Kawachi N, Belbin TJ, Angeletti R, Prystowsky MB, Childs G, Segall JE., Free PMC Article

    10/14/2017
    In this study, the authors found that the actin filament bundling abilities of PLS1 and PLS2 were similarly sensitive to Ca(2+) (pCa50 ~6.4), whereas PLS3 was less sensitive (pCa50 ~5.9).

    The Roles of Actin-Binding Domains 1 and 2 in the Calcium-Dependent Regulation of Actin Filament Bundling by Human Plastins.
    Schwebach CL, Agrawal R, Lindert S, Kudryashova E, Kudryashov DS.

    08/19/2017
    elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin levels.

    Fascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia.
    Van Audenhove I, Denert M, Boucherie C, Pieters L, Cornelissen M, Gettemans J., Free PMC Article

    11/5/2016
    Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils.

    L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions.
    Dubey M, Singh AK, Awasthi D, Nagarkoti S, Kumar S, Ali W, Chandra T, Kumar V, Barthwal MK, Jagavelu K, Sánchez-Gómez FJ, Lamas S, Dikshit M.

    06/4/2016
    association of SNPs in LCP1 and CTIF with hearing

    Association of SNPs in LCP1 and CTIF with hearing in 11 year old children: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium.
    Harrison S, Lewis SJ, Hall AJ, Vuckovic D, Girotto G, Martin RM, Adams JC., Free PMC Article

    03/5/2016
    An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer

    An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer.
    Chen C, Cai Q, He W, Li Z, Zhou F, Liu Z, Zhong G, Chen X, Zhao Y, Dong W, Huang J, Zheng J, Lin T.

    02/13/2016
    The proteins (HSP90b, TSM1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.

    Potential diagnostic significance of HSP90, ACS/TMS1, and L-plastin in the identification of melanoma.
    Strickler AG, Vasquez JG, Yates N, Ho J.

    08/15/2015
    Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets.

    Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.
    Ning Y, Gerger A, Zhang W, Hanna DL, Yang D, Winder T, Wakatsuki T, Labonte MJ, Stintzing S, Volz N, Sunakawa Y, Stremitzer S, El-Khoueiry R, Lenz HJ., Free PMC Article

    02/21/2015
    L-plastin plays an important role in the clustering of NKG2D into lipid rafts, and it participates in NKG2D-mediated inhibition of NK cell chemotaxis.

    L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration.
    Serrano-Pertierra E, Cernuda-Morollón E, Brdička T, Hoøejši V, López-Larrea C., Free PMC Article

    01/17/2015
    expression of L-plastin promotes tumor metastasis and, importantly, that this effect depends on an additionally required phosphorylation of L-plastin

    Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation.
    Riplinger SM, Wabnitz GH, Kirchgessner H, Jahraus B, Lasitschka F, Schulte B, van der Pluijm G, van der Horst G, Hämmerling GJ, Nakchbandi I, Samstag Y., Free PMC Article

    09/13/2014
    L-plastin is indispensable for podosome formation and function in macrophages.

    L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages.
    De Clercq S, Boucherie C, Vandekerckhove J, Gettemans J, Guillabert A., Free PMC Article

    09/6/2014
    LCP1 is functionally relevant to CXCL12 induced B-cell migration.

    Lymphocyte cytosolic protein 1 is a chronic lymphocytic leukemia membrane-associated antigen critical to niche homing.
    Dubovsky JA, Chappell DL, Harrington BK, Agrawal K, Andritsos LA, Flynn JM, Jones JA, Paulaitis ME, Bolon B, Johnson AJ, Byrd JC, Muthusamy N., Free PMC Article

    01/11/2014
    High serum LCP1 is associated with kidney cancer.

    Composite three-marker assay for early detection of kidney cancer.
    Su Kim D, Choi YD, Moon M, Kang S, Lim JB, Kim KM, Park KM, Cho NH.

    09/14/2013
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