| cleaning behavior can be triggered through recognition of DAP-type PGN by its receptor PGRP-LC. | The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila.
Yanagawa A, Neyen C, Lemaitre B, Marion-Poll F., Free PMC Article | 12/2/2017 |
| Protofibrils of peptidoglycan receptors PGRP-LC and PGRP-LE seed immune deficiency protein (Imd) amyloid polymerization via Imd RIP homotypic interaction motif (RHIM), and the formation of functional Imd amyloid fibril is required for NF-kappaB signaling. | Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.
Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N., Free PMC Article | 11/11/2017 |
| this study identifies a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria | The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors.
Neyen C, Runchel C, Schüpfer F, Meier P, Lemaitre B., Free PMC Article | 06/3/2017 |
| PGRP-LC immune receptor regulates trans-synaptic signaling, a novel activity for innate immune signaling. | The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity.
Harris N, Braiser DJ, Dickman DK, Fetter RD, Tong A, Davis GW., Free PMC Article | 04/30/2016 |
| Silencing TM9SF4 prevents plasma membrane localization of PGRP-LC, whereas silencing TM9SF2 does not, which may account for the non-redundant role of TM9SF4 in phagocytosis of Gram-negative bacteria. | The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila.
Perrin J, Mortier M, Jacomin AC, Viargues P, Thevenon D, Fauvarque MO., Free PMC Article | 08/15/2015 |
| The steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. | Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity.
Rus F, Flatt T, Tong M, Aggarwal K, Okuda K, Kleino A, Yates E, Tatar M, Silverman N., Free PMC Article | 08/10/2013 |
| our study delineates how a combination of extracellular sensing by PGRP-LC isoforms and intracellular sensing through PGRP-LE provides sophisticated mechanisms to detect and differentiate between infections in Drosophila. | Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE.
Neyen C, Poidevin M, Roussel A, Lemaitre B. | 10/20/2012 |
| The authors show that stimulation of the Drosophila pattern recognition protein PGRP-LCx induces DIAP2-dependent polyubiquitylation of the initiator caspase DREDD. | Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.
Meinander A, Runchel C, Tenev T, Chen L, Kim CH, Ribeiro PS, Broemer M, Leulier F, Zvelebil M, Silverman N, Meier P., Free PMC Article | 08/25/2012 |
| Data show that the Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway. | The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.
Basbous N, Coste F, Leone P, Vincentelli R, Royet J, Kellenberger C, Roussel A., Free PMC Article | 08/6/2011 |
| PGRP-LE and PGRP-LC play a crucial role in detecting extracellular and intracellular bacteria with DAP-type peptidoglycans to induce various innate immune responses | Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC.
Kurata S., Free PMC Article | 06/28/2010 |
| By genetically interacting with PGRP-LC, PGRP-LF prevents constitutive activation of both the JNK and the immune deficiency pathways in the absence of infection. | The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation.
Maillet F, Bischoff V, Vignal C, Hoffmann J, Royet J. | 01/21/2010 |
| Cleavage or down-regulation of PGRP-LC may provide an additional cue for the host to distinguish pathogenic microbes and subsequently activate multiple host defense systems in Drosophila, thereby combating bacterial infection and initiating tissue repair. | Infection-induced proteolysis of PGRP-LC controls the IMD activation and melanization cascades in Drosophila.
Schmidt RL, Trejo TR, Plummer TB, Platt JL, Tang AH. | 01/21/2010 |
| Toll and immune deficiency pathway of PGRP-LC activate an immune response in Drosophila melanogaster. | Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster.
Tanji T, Hu X, Weber AN, Ip YT., Free PMC Article | 01/21/2010 |
| required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappaB family transcription factor Relish | Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila.
Choe KM, Werner T, Stöven S, Hultmark D, Anderson KV. | 01/21/2010 |
| Drosophila receptor for E. coli: essential component for recognition and signalling of Gram-negative bacteria | Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.
Rämet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA. | 01/21/2010 |
| PGRP-LC functions synergistically with PGRP-LE in producing resistance to Escherichia coli and Bacillus megaterium infections. | Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity.
Takehana A, Yano T, Mita S, Kotani A, Oshima Y, Kurata S., Free PMC Article | 01/21/2010 |
| Using RNA interference in Drosophila mbn-2 cells, we found that PGRP-LCx is the only isoform required to mediate signals from Gram-positive bacteria and purified bacterial peptidoglycan. | Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycan.
Werner T, Borge-Renberg K, Mellroth P, Steiner H, Hultmark D. | 01/21/2010 |
| Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. | The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.
Gottar M, Gobert V, Michel T, Belvin M, Duyk G, Hoffmann JA, Ferrandon D, Royet J. | 01/21/2010 |
| crystal structure at 2.1 angstrom resolution of tracheal cytotoxin (TCT) in complex with the ectodomains of PGRP-LCa and PGRP-LCx shows that TCT is bound to and presented by the LCx ectodomain for recognition by the LCa ectodomain | Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor.
Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J. | 01/21/2010 |
| Interaction with the imd signaling protein is not required for PGRP-LC signaling. Instead, PGRP-LC signals through a receptor-interacting protein homotypic interaction motif-like motif. | PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan.
Kaneko T, Yano T, Aggarwal K, Lim JH, Ueda K, Oshima Y, Peach C, Erturk-Hasdemir D, Goldman WE, Oh BH, Kurata S, Silverman N. | 01/21/2010 |
| PGRP-LC acts as a signal-transducing innate immune receptor. | Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor.
Choe KM, Lee H, Anderson KV., Free PMC Article | 01/21/2010 |