| Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation. | Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation.
Stewart RK, Nguyen P, Laederach A, Volkan PC, Sawyer JK, Fox DT., Free PMC Article | 07/9/2024 |
| Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila. | Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
Desai M, Hemant, Deo A, Naik J, Dhamale P, Kshirsagar A, Bose T, Majumdar A., Free PMC Article | 05/9/2024 |
| Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like beta-sheets. | Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets.
Bowler JT, Sawaya MR, Boyer DR, Cascio D, Bali M, Eisenberg DS., Free PMC Article | 11/12/2022 |
| The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis. | The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis.
Gilmutdinov R, Kozlov EN, Yakovlev KV, Olenina LV, Kotov AA, Barr J, Zhukova M, Schedl P, Shidlovskii YV., Free PMC Article | 11/6/2021 |
| Droplet and fibril formation of the functional amyloid Orb2. | Droplet and fibril formation of the functional amyloid Orb2.
Ashami K, Falk AS, Hurd C, Garg S, Cervantes SA, Rawat A, Siemer AB., Free PMC Article | 08/28/2021 |
| Implications of the Orb2 Amyloid Structure in Huntington's Disease. | Implications of the Orb2 Amyloid Structure in Huntington's Disease.
Hervás R, Murzin AG, Si K., Free PMC Article | 02/27/2021 |
| We present here evidences of a novel genetic mechanism to regulate synapse fine tuning during development and propose an equilibrium between Orb2 conformational state and nervous system formation. | Orb2 as modulator of Brat and their role at the neuromuscular junction.
Santana E, Casas-Tintó S. | 07/28/2018 |
| The N-terminus of Orb2A not only promotes the formation of fibrils, but also forms the fibril core. | Identification and Structural Characterization of the N-terminal Amyloid Core of Orb2 isoform A.
Cervantes SA, Bajakian TH, Soria MA, Falk AS, Service RJ, Langen R, Siemer AB., Free PMC Article | 06/2/2018 |
| Data confirm the original hypothesis that the glutamine, histidine-rich (Q/H-rich) domain of Orb2 can bind to transition metals via its His residues. Hence, the Q/H rich domain behaves like other H-rich domains, most of which were shown to be metal binding domains. | Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2.
Bajakian TH, Cervantes SA, Soria MA, Beaugrand M, Kim JY, Service RJ, Siemer AB., Free PMC Article | 03/10/2018 |
| Study showed that the N-terminus specific to Orb2A can bind to lipid membranes; binding occurs preferentially to curved membranes and requires the membranes to be negatively charged. When binding to lipid membranes, the N-terminus of Orb2A undergoes a transition from a dynamic, intrinsically disordered state to a less dynamic alpha-helix. This lipid membrane interaction can prevent the N-terminus from forming amyloid f... | The Functional Amyloid Orb2A Binds to Lipid Membranes.
Soria MA, Cervantes SA, Bajakian TH, Siemer AB., Free PMC Article | 08/26/2017 |
| Authors posit that pasilla-mediated processing of unspliced Orb2A mRNA integrates experience and internal state to control Orb2A protein abundance and long-term memory formation. | Regulated Intron Removal Integrates Motivational State and Experience.
Gill J, Park Y, McGinnis JP, Perez-Sanchez C, Blanchette M, Si K., Free PMC Article | 07/15/2017 |
| rapidly forms amyloids and its toxic intermediates are extremely transient | Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.
Hervás R, Li L, Majumdar A, Fernández-Ramírez Mdel C, Unruh JR, Slaughter BD, Galera-Prat A, Santana E, Suzuki M, Nagai Y, Bruix M, Casas-Tintó S, Menéndez M, Laurents DV, Si K, Carrión-Vázquez M., Free PMC Article | 06/11/2016 |
| Data support a model in which monomeric Orb2 keeps target mRNA in a translationally dormant state and experience-dependent conversion to the amyloidogenic state activates translation, resulting in persistent alteration of synaptic activity and stabilization of memory. | Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator.
Khan MR, Li L, Pérez-Sánchez C, Saraf A, Florens L, Slaughter BD, Unruh JR, Si K., Free PMC Article | 04/9/2016 |
| we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of mushroom body neurons for later consolidation. Consolidation involves the subsequent recruitment of Orb2B and the activity-dependent synthesis of CaMKII | Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila.
Krüttner S, Traunmüller L, Dag U, Jandrasits K, Stepien B, Iyer N, Fradkin LG, Noordermeer JN, Mensh BD, Keleman K., Free PMC Article | 03/26/2016 |
| This study demonstrated that The Drosophila lingerer protein cooperates with Orb2 in long-term memory formation. | The Drosophila lingerer protein cooperates with Orb2 in long-term memory formation.
Kimura S, Sakakibara Y, Sato K, Ote M, Ito H, Koganezawa M, Yamamoto D. | 10/31/2015 |
| Tob-Orb2 association is modulated by neuronal activity and Tob activity in the mushroom body is required for stable memory formation. | Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2.
White-Grindley E, Li L, Mohammad Khan R, Ren F, Saraf A, Florens L, Si K., Free PMC Article | 10/18/2014 |
| analysis of a partial loss of function orb2 mutant suggests that the orb2 differentiation phenotypes are independent of the earlier arrest in meiosis | The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.
Xu S, Hafer N, Agunwamba B, Schedl P., Free PMC Article | 05/18/2013 |
| This study demonistrated that Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain. | Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain.
Krüttner S, Stepien B, Noordermeer JN, Mommaas MA, Mechtler K, Dickson BJ, Keleman K., Free PMC Article | 01/5/2013 |