| Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3. | Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3.
Abbey CA, Duran CL, Chen Z, Chen Y, Roy S, Coffell A, Sveeggen TM, Chakraborty S, Wells GB, Chang J, Bayless KJ., | 04/26/2024 |
| KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells. | KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
Shan M, Liu D, Sun L, Yang M, He M, Zhang Y, Xiang L, Lu L, He H, Niu D, Chen L, Li S, Chen A, He F, Wang Y, Lian J. | 02/28/2024 |
| Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma. | Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma.
Basbous S, Dif L, Dantzer C, Di-Tommaso S, Dupuy JW, Bioulac-Sage P, Raymond AA, Desdouets C, Saltel F, Moreau V., Free PMC Article | 01/17/2024 |
| Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling. | Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling.
Almarán B, Ramis G, Fernández de Mattos S, Villalonga P., Free PMC Article | 12/31/2022 |
| RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway. | RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway.
Dai L, Chen X, Zhang H, Zeng H, Yin Z, Ye Z, Wei Y. | 07/2/2022 |
| Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence. | Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence.
Basbous S, Paysan L, Sena S, Allain N, Hiriart JB, Dugot-Senant N, Rousseau B, Chevret E, Lagrée V, Moreau V. | 05/21/2022 |
| HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3. | HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.
Hu XC, Chu J, Zhou Y, Li CC, Zhou GJ, Jiang GQ. | 04/9/2022 |
| Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers. | Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.
Kakurina GV, Cheremisina OV, Sereda EE, Kolegova ES, Kondakova IV, Choinzonov EL. | 01/22/2022 |
| Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma. | Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.
Zhao K, Yuan WH, Li WJ, Chi ZP, Wang SR, Chen ZG., Free PMC Article | 10/16/2021 |
| Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARgamma-UCP2 cascade. | Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARγ-UCP2 cascade.
Huang L, Ma Y, Chen L, Chang J, Zhong M, Wang Z, Sun Y, Chen X, Sun F, Xiao L, Chen J, Lai Y, Yan C, Yue X. | 07/24/2021 |
| uncovered a novel differential expression of adipose RND3 in obesity and insulin resistance, which may at least partly depend on a causal effect of RND3 on adipocyte lipolysis. | The Rho GTPase RND3 regulates adipocyte lipolysis.
Dankel SN, Røst TH, Kulyté A, Fandalyuk Z, Skurk T, Hauner H, Sagen JV, Rydén M, Arner P, Mellgren G. | 02/22/2020 |
| The study uncovers RhoE as a new fine-tuning factor modulating myocardial infarction-induced inflammation and promoting injured heart recovery. | RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction.
Dai Y, Song J, Li W, Yang T, Yue X, Lin X, Yang X, Luo W, Guo J, Wang X, Lai S, Andrade KC, Chang J., Free PMC Article | 12/7/2019 |
| In pre-eclampsia, increased miRNA-182-5p expression could inhibit the migratory and invasive ability of trophoblast cells through targeted degradation of RND3 protein. | Highly expressed miR-182-5p can promote preeclampsia progression by degrading RND3 and inhibiting HTR-8/SVneo cell invasion.
Fang YN, Huang ZL, Li H, Tan WB, Zhang QG, Wang L, Wu JL. | 12/7/2019 |
| RND3 bound p65 and promoted the ubiquitination of p65 protein, leading to reduced expression of p65 protein and inhibition of the NF-kappaB signalling pathway and its downstream target genes IL-8 and BCL-2 to promote apoptosis in GBM cells. | Small GTPase RHOE/RND3, a new critical regulator of NF-κB signalling in glioblastoma multiforme?
Sun Q, Dong H, Li Y, Yuan F, Xu Y, Mao S, Xiong X, Chen Q, Liu B., Free PMC Article | 10/26/2019 |
| Rnd3 is a MKL1-SRF target that plays a key role in the feedback loop described between the MKL1-SRF pathway and the organization of the actin cytoskeleton | Rnd3/RhoE expression is regulated by G-actin through MKL1-SRF signaling pathway.
Piquet L, Robbe T, Neaud V, Basbous S, Rosciglione S, Saltel F, Moreau V. | 09/21/2019 |
| miR200b and miR200c targeted the expression of RhoE and inhibited the malignancy of nonsmall cell lung cancer (NSCLC) cells, and the downregulation of miR200b and miR200c may contribute to the high expression of RhoE in NSCLC. | miR-200b/c targets the expression of RhoE and inhibits the proliferation and invasion of non-small cell lung cancer cells.
Tang Q, Li M, Chen L, Bi F, Xia H. | 12/22/2018 |
| TUG1 can epigenetically inhibit the level of RND3 through binding to EZH2, thus promoting pre-eclampsia development. | The lncRNA TUG1 modulates proliferation in trophoblast cells via epigenetic suppression of RND3.
Xu Y, Ge Z, Zhang E, Zuo Q, Huang S, Yang N, Wu D, Zhang Y, Chen Y, Xu H, Huang H, Jiang Z, Sun L., Free PMC Article | 06/9/2018 |
| RND3 promotes Snail 1 protein degradation in glioblastoma tumor cells, promoting cell migration and neoplasm invasiveness. | RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion.
Liu B, Dong H, Lin X, Yang X, Yue X, Yang J, Li Y, Wu L, Zhu X, Zhang S, Tian D, Wang J, Cai Q, Mao S, Chen Q, Chang J., Free PMC Article | 02/24/2018 |
| RhoE and ROCK2 regulate chemoresistance in hepatocellular carcinoma. | RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma.
Ma W, Sze KM, Chan LK, Lee JM, Wei LL, Wong CM, Lee TK, Wong CC, Ng IO., Free PMC Article | 01/20/2018 |
| This study Gene-based tests suggest evidence of association with related genes, ZEB2, RND3, MCTP1, CTBP2, and beta EEG. | A genome wide association study of fast beta EEG in families of European ancestry.
Meyers JL, Zhang J, Manz N, Rangaswamy M, Kamarajan C, Wetherill L, Chorlian DB, Kang SJ, Bauer L, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Tischfield J, Wang JC, Edenberg HJ, Goate A, Foroud T, Porjesz B., Free PMC Article | 08/26/2017 |
| plexin-B2 is a downstream target for Rnd3, which contributes to its cellular function. | Rnd3-induced cell rounding requires interaction with Plexin-B2.
McColl B, Garg R, Riou P, Riento K, Ridley AJ., Free PMC Article | 08/12/2017 |
| Studies provide evidence that Rnd3 plays a dual role in cells; on one hand, it regulates cell proliferation, on the other hand, Rnd3 plays an important role in regulating metastasis and invasion. [review] | Rnd3 in Cancer: A Review of the Evidence for Tumor Promoter or Suppressor.
Paysan L, Piquet L, Saltel F, Moreau V. | 08/12/2017 |
| Our data supported that RhoE could inhibit cell proliferation and promote apoptosis. Moreover, these tumor-suppressing effects might be acted through the negative regulation of EGFR/ERK signaling. | The Rho GTPase RhoE exerts tumor-suppressing effects in human esophageal squamous cell carcinoma via negatively regulating epidermal growth factor receptor.
Wang H, Wang Y, Liang B, He F, Li Y, Che J, Li X, Zhao H, Shi G. | 03/18/2017 |
| constant degradation of RND3 by chaperone-mediated autophagy is required to sustain rapid proliferation of gastric cancer cells. | Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer.
Zhou J, Yang J, Fan X, Hu S, Zhou F, Dong J, Zhang S, Shang Y, Jiang X, Guo H, Chen N, Xiao X, Sheng J, Wu K, Nie Y, Fan D., Free PMC Article | 12/31/2016 |
| RhoA-ROCK-Rnd3 feedback loop determined the local reassembly sites of the actin cortex during membrane blebbing. | A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing.
Aoki K, Maeda F, Nagasako T, Mochizuki Y, Uchida S, Ikenouchi J., Free PMC Article | 09/3/2016 |