| The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion. | The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.
Camp D, Venkatesh B, Solianova V, Varela L, Goult BT, Tanentzapf G., Free PMC Article | 06/3/2024 |
| Results demonstrate that Talin phosphorylation by Slik plays an important role in fine-tuning Talin recruitment to integrin adhesion sites and maintaining muscle attachment. | Slik phosphorylation of Talin T152 is crucial for proper Talin recruitment and maintenance of muscle attachment in Drosophila.
Katzemich A, Long JY, Panneton V, Fisher LAB, Hipfner D, Schöck F. | 06/27/2020 |
| Demonstrate a continuous requirement for Talin during heart growth to maintain one-to-one apposition of myofibril ends between cardiomyocytes. Retracted myofibrils cannot regenerate appositions to adjacent cells after restoration of Talin expression. | Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila.
Bogatan S, Cevik D, Demidov V, Vanderploeg J, Panchbhaya A, Vitkin A, Jacobs JR., Free PMC Article | 04/23/2016 |
| The different arrangements of the talin molecule relative to integrins suggest that talin is able to sense different force vectors, either parallel or perpendicular to the membrane. | Alternative mechanisms for talin to mediate integrin function.
Klapholz B, Herbert SL, Wellmann J, Johnson R, Parsons M, Brown NH., Free PMC Article | 01/16/2016 |
| Talin provides instructive cues to position the luminal domain and coordinate the actin cytoskeleton during Drosophila heart lumen development | Talin is required to position and expand the luminal domain of the Drosophila heart tube.
Vanderploeg J, Jacobs JR. | 11/21/2015 |
| We propose that the talin head domain is essential for regulating integrin avidity in Drosophila and that this is crucial for integrin-mediated adhesion during animal development. | The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
Ellis SJ, Lostchuck E, Goult BT, Bouaouina M, Fairchild MJ, López-Ceballos P, Calderwood DA, Tanentzapf G., Free PMC Article | 11/14/2015 |
| Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitor | Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors.
Pézeron G, Millen K, Boukhatmi H, Bray S., Free PMC Article | 09/5/2015 |
| talin integrin binding sites reinforce integrin attachment to the extracellular matrix and reinforce the link between integrins and the intracellular adhesion complex | In vivo functional analysis reveals specific roles for the integrin-binding sites of talin.
Ellis SJ, Pines M, Fairchild MJ, Tanentzapf G. | 09/3/2011 |
| Data show that introduction of mutations that reduced actin binding in vitro into the isolated C-terminal Talin-ABD impaired actin binding in vivo. | Distinct developmental roles for direct and indirect talin-mediated linkage to actin.
Franco-Cea A, Ellis SJ, Fairchild MJ, Yuan L, Cheung TY, Tanentzapf G. | 09/20/2010 |
| crystal structure of the talin IBS2 domain, which forms a five-helix bundle | Crystal structure of the talin integrin binding domain 2.
Cheung TY, Fairchild MJ, Zarivach R, Tanentzapf G, Van Petegem F. | 01/21/2010 |
| Mutagenesis of the integrin cytoplasmic domain, within the chimera, showed the dominant-negative inhibition was not due to talin sequestration alone and that additional interactions are required. | Multiple factors contribute to integrin-talin interactions in vivo.
Tanentzapf G, Martin-Bermudo MD, Hicks MS, Brown NH. | 01/21/2010 |
| Results provide evidence that integrin-talin adhesion complexes are necessary to maintain tracheal terminal branches and luminal organization. | Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization.
Levi BP, Ghabrial AS, Krasnow MA. | 01/21/2010 |
| talin is essential for integrin function and acts by stably linking clusters of extracellular matrix-linked integrins to the cytoskeleton. | Talin is essential for integrin function in Drosophila.
Brown NH, Gregory SL, Rickoll WL, Fessler LI, Prout M, White RA, Fristrom JW. | 01/21/2010 |
| Talin represses the expression of Drosophila melanogaster DE-cadherin. | Talin's second persona.
Tepass U, Godt D. | 01/21/2010 |
| Follicle cells that are mutant for talin show a strikingly high level of DE-cadherin, due to elevated transcription of DE-cadherin. | Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila.
Bécam IE, Tanentzapf G, Lepesant JA, Brown NH, Huynh JR. | 01/21/2010 |