| The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality. | The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality.
Kamalyan S, Kyrchanova O, Klimenko N, Babosha V, Vasileva Y, Belova E, Fursenko D, Maksimenko O, Georgiev P., Free PMC Article | 04/5/2024 |
| CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles. | CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles.
Cavalheiro GR, Girardot C, Viales RR, Pollex T, Cao TBN, Lacour P, Feng S, Rabinowitz A, Furlong EEM., Free PMC Article | 02/10/2023 |
| Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements. | Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements.
Kahn TG, Savitsky M, Kuong C, Jacquier C, Cavalli G, Chang JM, Schwartz YB., Free PMC Article | 02/10/2023 |
| The Variable CTCF Site from Drosophila melanogaster Ubx Gene is Redundant and Has no Insulator Activity. | The Variable CTCF Site from Drosophila melanogaster Ubx Gene is Redundant and Has no Insulator Activity.
Ibragimov AN, Bylino OV, Kyrchanova OV, Shidlovskii YV, White R, Schedl P, Georgiev PG., Free PMC Article | 09/3/2022 |
| Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators. | Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators.
Kyrchanova OV, Postika NY, Sokolov VV, Georgiev PG., Free PMC Article | 03/19/2022 |
| Drosophila architectural protein CTCF is not essential for fly survival and is able to function independently of CP190. | Drosophila architectural protein CTCF is not essential for fly survival and is able to function independently of CP190.
Kyrchanova O, Klimenko N, Postika N, Bonchuk A, Zolotarev N, Maksimenko O, Georgiev P. | 10/2/2021 |
| CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions. | CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions.
Kaushal A, Mohana G, Dorier J, Özdemir I, Omer A, Cousin P, Semenova A, Taschner M, Dergai O, Marzetta F, Iseli C, Eliaz Y, Weisz D, Shamim MS, Guex N, Lieberman Aiden E, Gambetta MC., Free PMC Article | 03/6/2021 |
| N-terminal domain of the architectural protein CTCF has similar structural organization and ability to self-association in bilaterian organisms. | N-terminal domain of the architectural protein CTCF has similar structural organization and ability to self-association in bilaterian organisms.
Bonchuk A, Kamalyan S, Mariasina S, Boyko K, Popov V, Maksimenko O, Georgiev P., Free PMC Article | 11/21/2020 |
| Results indicate that loss of Drosophila CTCF is not accompanied by widespread effects on gene expression, which may be due to redundant functions with other Insulator binding proteins. | The Insulator Protein CTCF Is Required for Correct Hox Gene Expression, but Not for Embryonic Development in Drosophila.
Gambetta MC, Furlong EEM., Free PMC Article | 12/22/2018 |
| CTCF role in the decompaction of condensed bands in the Drosophila melanogaster polytene chromosomes and replication timing | Tethering of CHROMATOR and dCTCF proteins results in decompaction of condensed bands in the Drosophila melanogaster polytene chromosomes but does not affect their transcription and replication timing.
Pokholkova GV, Demakov SA, Andreenkov OV, Andreenkova NG, Volkova EI, Belyaeva ES, Zhimulev IF., Free PMC Article | 07/21/2018 |
| Mutation of the Mcp Pita site disrupts blocking activity and also eliminates dCTCF binding. In contrast, mutation of the Mcp dCTCF site does not affect Pita binding, and this mutant boundary retains partial function. | Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.
Kyrchanova O, Zolotarev N, Mogila V, Maksimenko O, Schedl P, Georgiev P., Free PMC Article | 09/30/2017 |
| TCF participates in the recruitment of Smad proteins to a subset of genomic sites and in the redistribution of these proteins in response to BMP signaling. | CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster.
Van Bortle K, Peterson AJ, Takenaka N, O'Connor MB, Corces VG., Free PMC Article | 05/28/2016 |
| Drosophila CTCF-CP190 interactions are less critical for the in vivo functions of the CTCF protein than the N-terminal CTCF - CTCF interaction domain. | Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.
Bonchuk A, Maksimenko O, Kyrchanova O, Ivlieva T, Mogila V, Deshpande G, Wolle D, Schedl P, Georgiev P., Free PMC Article | 04/9/2016 |
| Results show that CP190 binds to CTCF or to other DNA binding insulator factors serving as a binding platform for compexes with enzymatic function, like NURF and dREAM. | A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking.
Bohla D, Herold M, Panzer I, Buxa MK, Ali T, Demmers J, Krüger M, Scharfe M, Jarek M, Bartkuhn M, Renkawitz R., Free PMC Article | 06/27/2015 |
| Evolutionarily conserved ENY2 is responsible for barrier activity mediated by the dCTCF protein. | Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity.
Maksimenko O, Kyrchanova O, Bonchuk A, Stakhov V, Parshikov A, Georgiev P., Free PMC Article | 05/16/2015 |
| CTCF aligns in the genome with Suppressor of Hairy wing and Boundary Element Associated Factor of 32 kDa at the borders of H3K27me3 domains. | Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains.
Van Bortle K, Ramos E, Takenaka N, Yang J, Wahi JE, Corces VG., Free PMC Article | 04/13/2013 |
| Data show that AGO2 interacts physically with CTCF and CP190, and depletion of either CTCF or CP190 results in genome-wide loss of AGO2 chromatin association. | RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function.
Moshkovich N, Nisha P, Boyle PJ, Thompson BA, Dale RK, Lei EP., Free PMC Article | 12/10/2011 |
| CTCF in Drosophila functions in maintaining parent-specific expression from an imprinted domain as it does in mammals. | The Drosophila homolog of the mammalian imprint regulator, CTCF, maintains the maternal genomic imprint in Drosophila melanogaster.
MacDonald WA, Menon D, Bartlett NJ, Sperry GE, Rasheva V, Meller V, Lloyd VK., Free PMC Article | 10/30/2010 |
| CTCF plays more active roles in regulating gene activity and it functions differently from other insulator proteins in organizing the Drosophila genome. | Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization.
Smith ST, Wickramasinghe P, Olson A, Loukinov D, Lin L, Deng J, Xiong Y, Rux J, Sachidanandam R, Sun H, Lobanenkov V, Zhou J., Free PMC Article | 01/21/2010 |
| CTCF itself is critical for Fab-8 enhancer blocking. | Drosophila CTCF is required for Fab-8 enhancer blocking activity in S2 cells.
Ciavatta D, Rogers S, Magnuson T., Free PMC Article | 01/21/2010 |
| Su(Hw) interacting factor CP190 largely overlapped with dCTCF binding sites and interacts with dCTCF. Binding of dCTCF to targets requires CP190 | The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.
Mohan M, Bartkuhn M, Herold M, Philippen A, Heinl N, Bardenhagen I, Leers J, White RA, Renkawitz-Pohl R, Saumweber H, Renkawitz R., Free PMC Article | 01/21/2010 |