| miR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-betaR1/Smad pathway. | miR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-βR1/Smad pathway.
Yao H, Qian J, Bian XT, Guo L, Tang KL, Tao X., Free PMC Article | 10/2/2024 |
| miR-27b-3p a Negative Regulator of DSB-DNA Repair. | miR-27b-3p a Negative Regulator of DSB-DNA Repair.
Peraza-Vega RI, Valverde M, Rojas E., Free PMC Article | 07/29/2024 |
| The crucial relationship between miRNA-27 and CSE/H2S, and the mechanism of action of GLP-1 in myocardial hypertrophy. | The crucial relationship between miRNA-27 and CSE/H(2)S, and the mechanism of action of GLP-1 in myocardial hypertrophy.
Gao S, Li Y, Liu MM, Xiong X, Cui CP, Huo QJ, Li KX, Sun X, Zhang R, Wu D, Li BY., Free PMC Article | 04/18/2024 |
| The potential of leptin to alleviate chronic heart failure through miR-27a/b-3p: A preclinical study. | The potential of leptin to alleviate chronic heart failure through miR-27a/b-3p: A preclinical study.
Yan J, Xiao J, Duan J, Hong T. | 01/3/2024 |
| Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis. | Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis.
Tang Y, Yang LJ, Liu H, Song YJ, Yang QQ, Liu Y, Qian SW, Tang QQ. | 02/11/2023 |
| MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling. | MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling.
Li G, Shao Y, Guo HC, Zhi Y, Qiao B, Ma K, Du J, Lai YQ, Li Y., Free PMC Article | 08/6/2022 |
| MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-alpha-induced protein 3). | MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3).
Li L, Qi C, Liu Y, Shen Y, Zhao X, Qin H, Zhang Y, Yu T., Free PMC Article | 02/19/2022 |
| microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-kappaB signaling pathway. | microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-κB signaling pathway.
Sun J, Sun X, Chen J, Liao X, He Y, Wang J, Chen R, Hu S, Qiu C., Free PMC Article | 07/17/2021 |
| Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-gamma Pathway via miR-27b-5p Regulation. | Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-γ Pathway via miR-27b-5p Regulation.
Zhang J, Powell CA, Kay MK, Sonkar R, Meruvu S, Choudhury M., Free PMC Article | 04/17/2021 |
| MicroRNA-27 attenuates pressure overload-Induced cardiac hypertrophy and dysfunction by targeting galectin-3. | MicroRNA-27 attenuates pressure overload-Induced cardiac hypertrophy and dysfunction by targeting galectin-3.
Zhang M, Cheng K, Chen H, Tu J, Shen Y, Pang L, Wu W. | 10/10/2020 |
| MiR-27b-3p induces acyl-CoA thioesterase 2 (ACOT2) expression in 3T3-L1 cells. | Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression.
Murata Y, Yamashiro T, Kessoku T, Jahan I, Usuda H, Tanaka T, Okamoto T, Nakajima A, Wada K., Free PMC Article | 06/13/2020 |
| Our study for the first time implicates the role of miR-27b in insulin resistance (IR) by virtue of its target binding site in the 3'UTR region of INSR and highlights the importance of miR-27b in the pathophysiology of IR and type 2 diabetes. | Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor.
Srivastava A, Shankar K, Beg M, Rajan S, Gupta A, Varshney S, Kumar D, Gupta S, Mishra RK, Gaikwad AN. | 10/12/2019 |
| MicroRNA-27b-3p inhibits apoptosis of chondrocyte in rheumatoid arthritis by targeting HIPK2 | MicroRNA-27b-3p inhibits apoptosis of chondrocyte in rheumatoid arthritis by targeting HIPK2.
Zhou Y, Li S, Chen P, Yang B, Yang J, Liu R, Li J, Xia D. | 09/7/2019 |
| A novel role of the miR-27b/Bag2 axis in the regulation of inflammatory response. | MicroRNA-27b Modulates Inflammatory Response and Apoptosis during Mycobacterium tuberculosis Infection.
Liang S, Song Z, Wu Y, Gao Y, Gao M, Liu F, Wang F, Zhang Y. | 04/13/2019 |
| In primary cultured brain microvascular endothelial cells (BMECs), the inhibition of miRNA-27b induced the activation of adenosine monophosphate-activated protein kinase (AMPK), which increased tube formation and migration. This action was attenuated when AMPKalpha2 was knocked down. Enhanced angiogenesis in ischemic boundary zone and improved outcome found in model mice treated with Lentivirus miR-27b inhibitor. | MiRNA-27b Regulates Angiogenesis by Targeting AMPK in Mouse Ischemic Stroke Model.
Yuan Y, Zhang Z, Wang Z, Liu J. | 03/23/2019 |
| 15d-PGJ2/PPARgamma axis promotes expression of miR-27b-3p, miR-181a-1-3p, and miR-326-5p. miR-27b-3p, miR-181a-1-3p, and miR-326-5p have an inhibitory effect on bone marrow (BM)-derived macrophage activation via 15d-PGJ2/PPARgamma axis. | miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury.
Li W, Chang N, Tian L, Yang J, Ji X, Xie J, Yang L, Li L. | 06/23/2018 |
| Shear stress-regulated miR-27b promotes the interaction of endothelial cells with pericytes, partly by repressing SEMA6A and SEMA6D. | Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.
Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. | 03/3/2018 |
| The exogenous administration of the downregulated let-7b-p3 mimetic or inhibitors of upregulated miR-23a or miR-27a decreased eosinophil recruitment and mucus and collagen production via controlling the expression of IL-4, IL-5, and IL-13. | Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation.
Aguilera-Aguirre L, Hao W, Pan L, Li X, Saavedra-Molina A, Bacsi A, Radak Z, Sur S, Brasier AR, Ba X, Boldogh I., Free PMC Article | 12/9/2017 |
| LncRNA Gm15290 regulates miR-27b to promote PPARgamma-induced fat deposition and contribute to body weight gain. | LncRNA Gm15290 sponges miR-27b to promote PPARγ-induced fat deposition and contribute to body weight gain in mice.
Liu W, Ma C, Yang B, Yin C, Zhang B, Xiao Y. | 10/28/2017 |
| miR-27b prevents endothelial progenitor cell apoptosis in Type 2 diabetic mice, at least in part, by suppressing p53 and the Bax/Bcl-2 ratio. | MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes.
Li H, Liu J, Wang Y, Fu Z, Hüttemann M, Monks TJ, Chen AF, Wang JM., Free PMC Article | 10/14/2017 |
| This is the first report showing significant therapeutic effect of miR-29b-3p on femoral fracture healing through site-specific delivery with microbubble-ultrasound system. | miRNA-29b improves bone healing in mouse fracture model.
Lee WY, Li N, Lin S, Wang B, Lan HY, Li G. | 09/30/2017 |
| results suggest important roles of miR-27 in TGF-beta-driven endothelial-mesenchymal transition | Regulation of TGF-β-mediated endothelial-mesenchymal transition by microRNA-27.
Suzuki HI, Katsura A, Mihira H, Horie M, Saito A, Miyazono K., Free PMC Article | 09/9/2017 |
| We conclude that silencing of Bmi1 by miR-27b relieves repression of the presynaptic transcriptome and supports neurotransmission in cortical networks. | miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.
Poon VY, Gu M, Ji F, VanDongen AM, Fivaz M., Free PMC Article | 09/2/2017 |
| These results suggest that miR-27b-3p plays an important role in the posttranscriptional regulation of BMAL1 protein in the liver. | Rhythmic expression of miR-27b-3p targets the clock gene Bmal1 at the posttranscriptional level in the mouse liver.
Zhang W, Wang P, Chen S, Zhang Z, Liang T, Liu C. | 08/19/2017 |
| expression of a miR cluster mmu-miR-23-24-27, is upregulated in the cortical collecting duct by aldosterone. | A MicroRNA Cluster miR-23-24-27 Is Upregulated by Aldosterone in the Distal Kidney Nephron Where it Alters Sodium Transport.
Liu X, Edinger RS, Klemens CA, Phua YL, Bodnar AJ, LaFramboise WA, Ho J, Butterworth MB., Free PMC Article | 05/20/2017 |