| miR-195b is required for proper cellular homeostasis in the elderly. | miR-195b is required for proper cellular homeostasis in the elderly.
Muñoz-Gallardo MDM, Garcia-Padilla C, Vicente-Garcia C, Carvajal J, Arenega A, Franco D., Free PMC Article | 02/5/2024 |
| Mesenchymal Stem Cell-Derived Exosomes are Effective for Radiation Enteritis and Essential for the Proliferation and Differentiation of Lgr5[+] Intestinal Epithelial Stem Cells by Regulating Mir-195/Akt/beta-Catenin Pathway. | Mesenchymal Stem Cell-Derived Exosomes are Effective for Radiation Enteritis and Essential for the Proliferation and Differentiation of Lgr5(+) Intestinal Epithelial Stem Cells by Regulating Mir-195/Akt/β-Catenin Pathway.
Yang L, Fang C, Song C, Zhang Y, Zhang R, Zhou S., Free PMC Article | 09/6/2023 |
| MicroRNA-195a-5p Regulates Blood Pressure by Inhibiting NKCC2A. | MicroRNA-195a-5p Regulates Blood Pressure by Inhibiting NKCC2A.
Hao S, Zhao H, Hao DH, Ferreri NR., Free PMC Article | 01/28/2023 |
| Macrophage-derived exosomal miR-195a-5p impairs tubular epithelial cells mitochondria in acute kidney injury mice. | Macrophage-derived exosomal miR-195a-5p impairs tubular epithelial cells mitochondria in acute kidney injury mice.
Yuan L, Yang J, Liu F, Li L, Liu J, Chen Y, Cheng J, Lu Y, Yuan Y. | 12/24/2022 |
| MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6. | MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6.
Xia H, Zhao H, Yang W, Luo X, Wei J, Xia H. | 04/16/2022 |
| Vinclozolin-induced mouse penile malformation and ""small testis"" via miR132, miR195a together with the Hippo signaling pathway. | Vinclozolin-induced mouse penile malformation and "small testis" via miR132, miR195a together with the Hippo signaling pathway.
Yu H, Yang J, Zhang Y, Fu H, Yan Z, Zhu Y. | 10/9/2021 |
| Overexpression of miR-195-5p reduces osteoporosis through activating BMP-2/SMAD/Akt/RUNX2 pathway via targeting SMURF1. | Overexpression of miR-195-5p reduces osteoporosis through activating BMP-2/SMAD/Akt/RUNX2 pathway via targeting SMURF1.
Ye LC, Qian LF, Liang L, Jiang LJ, Che ZY, Guo YH. | 09/25/2021 |
| MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells. | MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells.
Fu SH, Lai MC, Zheng YY, Sun YW, Qiu JJ, Gui F, Zhang Q, Liu F., Free PMC Article | 09/25/2021 |
| miR-195 reduces age-related blood-brain barrier leakage caused by thrombospondin-1-mediated selective autophagy. | miR-195 reduces age-related blood-brain barrier leakage caused by thrombospondin-1-mediated selective autophagy.
Chen CY, Chao YM, Lin HF, Chen CJ, Chen CS, Yang JL, Chan JYH, Juo SH., Free PMC Article | 08/28/2021 |
| Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis. | Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis.
Hutter K, Rülicke T, Drach M, Andersen L, Villunger A, Herzog S., Free PMC Article | 07/24/2021 |
| Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury. | Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
He B, Chen W, Zeng J, Tong W, Zheng P., Free PMC Article | 07/24/2021 |
| Up-regulation of miR-195 contributes to cardiac hypertrophy-induced arrhythmia by targeting calcium and potassium channels. | Up-regulation of miR-195 contributes to cardiac hypertrophy-induced arrhythmia by targeting calcium and potassium channels.
Xuan L, Zhu Y, Liu Y, Yang H, Wang S, Li Q, Yang C, Jiao L, Zhang Y, Yang B, Sun L., Free PMC Article | 05/15/2021 |
| MiR-195 suppression alleviates apoptosis and oxidative stress in CCl4-induced ALI in mice by targeting Pim-1. | MiR-195 suppression alleviates apoptosis and oxidative stress in CCl4-induced ALI in mice by targeting Pim-1.
Yang K, Zou Z, Wu Y, Hu G. | 10/31/2020 |
| miR-195a might bind to circRNA_28313 and CSF1 and together form a circRNA-miRNA-mRNA network. | CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice.
Chen X, Ouyang Z, Shen Y, Liu B, Zhang Q, Wan L, Yin Z, Zhu W, Li S, Peng D., Free PMC Article | 03/21/2020 |
| study indicates that miR-195-5p promotes cardiac hypertrophy via targeting MFN2 and FBXW7 and may provide promising therapeutic strategies for interfering cardiac hypertrophy. | MiR-195-5p Promotes Cardiomyocyte Hypertrophy by Targeting MFN2 and FBXW7.
Wang L, Qin D, Shi H, Zhang Y, Li H, Han Q., Free PMC Article | 12/28/2019 |
| MiR195 overexpression inhibited the release of proinflammatory cytokines, including inducible nitric oxide synthase, interleukin6 (IL6) and tumor necrosis factoralpha, but induced the release of antiinflammatory cytokines in LPStreated BV2 cells, including IL4 and IL10. In addition, Rhoassociated kinase 1 (ROCK1), which is negatively regulated by miR195, was increased in LPSstimulated BV2 cells. | MicroRNA‑195 triggers neuroinflammation in Parkinson's disease in a Rho‑associated kinase 1‑dependent manner.
Ren Y, Li H, Xie W, Wei N, Liu M. | 09/7/2019 |
| The upregulation of miR-195a-3p due to HSF1 deficiency impaired cardiac angiogenesis by regulating AMPKalpha2/VEGF signaling. | HSF1 deficiency accelerates the transition from pressure overload-induced cardiac hypertrophy to heart failure through endothelial miR-195a-3p-mediated impairment of cardiac angiogenesis.
Wang S, Wu J, You J, Shi H, Xue X, Huang J, Xu L, Jiang G, Yuan L, Gong X, Luo H, Ge J, Cui Z, Zou Y. | 06/29/2019 |
| Increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of pyruvate dehydrogenase and ATP synthase that are essential for cardiac energy metabolism. | MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation.
Zhang X, Ji R, Liao X, Castillero E, Kennel PJ, Brunjes DL, Franz M, Möbius-Winkler S, Drosatos K, George I, Chen EI, Colombo PC, Schulze PC., Free PMC Article | 06/1/2019 |
| Our findings indicated that miR-195 inhibited WT and L613V RAF-1 induced hyperactive osteoblast differentiation in MC3T3-E1 cells by targeting RAF-1 | miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.
Chao C, Li F, Tan Z, Zhang W, Yang Y, Luo C. | 10/6/2018 |
| LNC00173 noncoding RNA regulates growth of the intestinal mucosa and stimulates intestinal epithelial renewal by reducing levels of miRNA195. | Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195.
Xiao L, Wu J, Wang JY, Chung HK, Kalakonda S, Rao JN, Gorospe M, Wang JY., Free PMC Article | 05/5/2018 |
| matrix metalloproteinase 2 (Mmp2) transcript is a target of miR-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model. | MicroRNA-195a-3p inhibits angiogenesis by targeting Mmp2 in murine mesenchymal stem cells.
Gao F, Sun M, Gong Y, Wang H, Wang Y, Hou H. | 01/20/2018 |
| miR-195-5p is a mechanosensitive gene that plays an important role in mechanical loading-induced osteogenic differentiation and bone formation in periodontal ligament cells. | MicroRNA-195-5p Regulates Osteogenic Differentiation of Periodontal Ligament Cells Under Mechanical Loading.
Chang M, Lin H, Fu H, Wang B, Han G, Fan M. | 10/7/2017 |
| Study demonstrated that deregulation of mfn2 played a critical role in the mitochondrial disorder during the progression of Alzheimer's disease, and its decreased expression was regulated at least in part by miR-195. Therefore, upregulation of mfn2 expression by decreasing the level of miR-195 might be a potential new therapeutic strategy for treatment of Alzheimer's disease. | MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice.
Zhang R, Zhou H, Jiang L, Mao Y, Cui X, Xie B, Cui D, Wang H, Zhang Q, Xu S. | 07/29/2017 |
| identified that miR-195 expression was upregulated in myocardial I/R injury, and miR-195 overexpression may promote cardiomyocyte apoptosis by targeting Bcl-2 and inducing mitochondrial apoptotic pathway | Roles of MicroRNA-195 in cardiomyocyte apoptosis induced by myocardial ischemia-reperfusion injury.
Gao CK, Liu H, Cui CJ, Liang ZG, Yao H, Tian Y. | 12/31/2016 |
| results indicate that miR-195a-5p inhibits MTEC1 proliferation, at least in part, via down-regulation of Smad7 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7.
Guo D, Ye Y, Qi J, Xu L, Zhang L, Tan X, Tan Z, Yu X, Zhang Y, Ma Y, Li Y., Free PMC Article | 12/17/2016 |