| Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis. | Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis.
Xing Y, Li P, Jia Y, Zhang K, Liu M, Jiang J., Free PMC Article | 08/9/2024 |
| miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis. | miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis.
Li H, Duan J, Zhang T, Fu Y, Xu Y, Miao H, Ge X., Free PMC Article | 08/1/2024 |
| Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury. | Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury.
Zhou C, Li S, Qiu N, Sun P, Hamblin MH, Dixon CE, Chen J, Yin KJ., Free PMC Article | 07/11/2024 |
| An essential role for miR-15/16 in Treg suppression and restriction of proliferation. | An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
Johansson K, Gagnon JD, Zhou SK, Fassett MS, Schroeder AW, Kageyama R, Bautista RA, Pham H, Woodruff PG, Ansel KM., Free PMC Article | 03/15/2024 |
| MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16. | MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16.
Lim S, Lee DE, Morena da Silva F, Koopmans PJ, Vechetti IJ Jr, von Walden F, Greene NP, Murach KA., Free PMC Article | 05/18/2023 |
| MicroRNA-16 inhibits the TLR4/NF-kappaB pathway and maintains tight junction integrity in irritable bowel syndrome with diarrhea. | MicroRNA-16 inhibits the TLR4/NF-κB pathway and maintains tight junction integrity in irritable bowel syndrome with diarrhea.
Xi M, Zhao P, Li F, Bao H, Ding S, Ji L, Yan J., Free PMC Article | 12/10/2022 |
| Knockdown of Chk1 inhibits proliferation and promotes apoptosis in mouse granulosa cells and its regulation mechanism by miR-15a and miR-16. | Knockdown of Chk1 inhibits proliferation and promotes apoptosis in mouse granulosa cells and its regulation mechanism by miR-15a and miR-16.
Liu XM, Chen F, Zhang F, Xi HT, Zhao JZ. | 10/8/2022 |
| Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner. | Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner.
Lim S, Deaver JW, Rosa-Caldwell ME, Lee DE, Morena da Silva F, Cabrera AR, Schrems ER, Saling LW, Washington TA, Fluckey JD, Greene NP., Free PMC Article | 05/14/2022 |
| T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity. | T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity.
Urena F, Ma C, Hoffmann FW, Nunes LGA, Urschitz J, Moisyadi S, Khadka VS, Deng Y, Hoffmann PR., Free PMC Article | 04/23/2022 |
| MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication Between Kupffer Cells and Regulatory T Cells. | MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication Between Kupffer Cells and Regulatory T Cells.
Liu N, Chang CW, Steer CJ, Wang XW, Song G. | 02/26/2022 |
| Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway. | Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway.
Sun P, Ma F, Xu Y, Zhou C, Stetler RA, Yin KJ., Free PMC Article | 01/15/2022 |
| miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms. | miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms.
Sewastianik T, Straubhaar JR, Zhao JJ, Samur MK, Adler K, Tanton HE, Shanmugam V, Nadeem O, Dennis PS, Pillai V, Wang J, Jiang M, Lin J, Huang Y, Brooks D, Bouxsein M, Dorfman DM, Pinkus GS, Robbiani DF, Ghobrial IM, Budnik B, Jarolim P, Munshi NC, Anderson KC, Carrasco RD., Free PMC Article | 10/16/2021 |
| Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis. | Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis.
Hutter K, Rülicke T, Drach M, Andersen L, Villunger A, Herzog S., Free PMC Article | 07/24/2021 |
| MicroRNA-16 directly binds to DEC2 and inactivates the TLR4 signaling pathway to inhibit lupus nephritis-induced kidney tissue hyperplasia and mesangial cell proliferation. | MicroRNA-16 directly binds to DEC2 and inactivates the TLR4 signaling pathway to inhibit lupus nephritis-induced kidney tissue hyperplasia and mesangial cell proliferation.
Qi H, Cao Q, Liu Q. | 06/12/2021 |
| Induced pluripotent stem cells-derived microvesicles accelerate deep second-degree burn wound healing in mice through miR-16-5p-mediated promotion of keratinocytes migration. | Induced pluripotent stem cells-derived microvesicles accelerate deep second-degree burn wound healing in mice through miR-16-5p-mediated promotion of keratinocytes migration.
Yan Y, Wu R, Bo Y, Zhang M, Chen Y, Wang X, Huang M, Liu B, Zhang L., Free PMC Article | 05/29/2021 |
| miR-16-5p is upregulated by amyloid beta deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2. | miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2.
Kim YJ, Kim SH, Park Y, Park J, Lee JH, Kim BC, Song WK. | 05/8/2021 |
| Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis. | Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis.
Inomata M, Kamio K, Azuma A, Matsuda K, Usuki J, Morinaga A, Tanaka T, Kashiwada T, Atsumi K, Hayashi H, Fujita K, Saito Y, Kubota K, Seike M, Gemma A. | 05/1/2021 |
| miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma. | miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma.
Chava S, Reynolds CP, Pathania AS, Gorantla S, Poluektova LY, Coulter DW, Gupta SC, Pandey MK, Challagundla KB., Free PMC Article | 02/6/2021 |
| The Effect of Increased miR-16-1 Levels in Mouse Embryos on Epigenetic Modification, Target Gene Expression, and Developmental Processes. | The Effect of Increased miR-16-1 Levels in Mouse Embryos on Epigenetic Modification, Target Gene Expression, and Developmental Processes.
Kiani M, Salehi M, Mogheiseh A, Mohammadi-Yeganeh S, Shahidi S. | 12/19/2020 |
| Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery. | Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery.
Sun P, Zhang K, Hassan SH, Zhang X, Tang X, Pu H, Stetler RA, Chen J, Yin KJ., Free PMC Article | 11/21/2020 |
| Inhibition of miR-16 Ameliorates Inflammatory Bowel Disease by Modulating Bcl-2 in Mouse Models. | Inhibition of miR-16 Ameliorates Inflammatory Bowel Disease by Modulating Bcl-2 in Mouse Models.
Chen Y, Shan T, Qu H, Chen Y, Wang N, Xia J. | 10/31/2020 |
| miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. | miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM., Free PMC Article | 09/5/2020 |
| Loss of miR16-1 expression is associated with B cell leukemia. | MiR-15a/16-1 deficiency induces IL-10-producing CD19(+) TIM-1(+) cells in tumor microenvironment.
Jia X, Liu H, Xu C, Han S, Shen Y, Miao X, Hu X, Lin Z, Qian L, Wang Z, Gong W., Free PMC Article | 07/4/2020 |
| Results suggested that miR-16-5p might be a critical factor involving the anti-inflammatory effects of calorie-restricted feeding. | MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
Yamada K, Takizawa S, Ohgaku Y, Asami T, Furuya K, Yamamoto K, Takahashi F, Hamajima C, Inaba C, Endo K, Matsui R, Kitamura H, Tanaka S. | 01/11/2020 |
| Mir-16 overexpression in mature neurites can depress dendritic branching and reduce the total length of dendrites. | MicroRNA-16 targets mRNA involved in neurite extension and branching in hippocampal neurons during presymptomatic prion disease.
Burak K, Lamoureux L, Boese A, Majer A, Saba R, Niu Y, Frost K, Booth SA. | 09/7/2019 |