| Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice. | Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice.
Mathew D, Barillas-Cerritos J, Nedeljkovic-Kurepa A, Abraham M, Taylor MD, Deutschman CS., Free PMC Article | 08/9/2023 |
| Expression of IRS2 in the female reproductive system during the estrous cycle in mice. | Expression of IRS2 in the female reproductive system during the estrous cycle in mice.
Wang Z, Yi B, Gan L, Li X, Liu X, Lv Q, Yang L. | 04/10/2023 |
| New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas. | New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas.
Shvadchenko AM, Volobueva MN, Ivanova VO, Beletskiy AP, Smirnova GR, Bal NV, Balaban PM. | 12/24/2022 |
| An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. | An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance.
Matsushita M, Awazawa M, Kobayashi N, Ikushima YM, Soeda K, Tamura-Nakano M, Muratani M, Kobayashi K, Blüher M, Brüning JC, Ueki K. | 05/7/2022 |
| Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease. | Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.
Ochiai T, Sano T, Nagayama T, Kubota N, Kadowaki T, Wakabayashi T, Iwatsubo T. | 03/5/2022 |
| Mutant Huntingtin Impairs Pancreatic beta-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington's Disease. | Mutant Huntingtin Impairs Pancreatic β-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington's Disease.
Li L, Sun Y, Zhang Y, Wang W, Ye C. | 03/5/2022 |
| The lack of Irs2 induces changes in the immunocytochemical expression of aromatase in the mouse retina. | The lack of Irs2 induces changes in the immunocytochemical expression of aromatase in the mouse retina.
Iglesias-Osma MC, Blanco EJ, Carretero-Hernández M, Catalano-Iniesta L, García-Barrado MJ, Sánchez-Robledo V, Blázquez JL, Carretero J. | 12/11/2021 |
| The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions. | The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions.
Nakahara M, Ito H, Skinner JT, Lin Q, Tamosiuniene R, Nicolls MR, Keegan AD, Johns RA, Yamaji-Kegan K., Free PMC Article | 09/25/2021 |
| The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells. | The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells.
Kunkemoeller B, Chen K, Lockhart SM, Wang X, Rask-Madsen C., Free PMC Article | 09/25/2021 |
| Irs2 deficiency alters hippocampus-associated behaviors during young adulthood. | Irs2 deficiency alters hippocampus-associated behaviors during young adulthood.
Tanokashira D, Wang W, Maruyama M, Kuroiwa C, White MF, Taguchi A., Free PMC Article | 08/28/2021 |
| Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice. | Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.
Takatani T, Shirakawa J, Shibue K, Gupta MK, Kim H, Lu S, Hu J, White MF, Kennedy RT, Kulkarni RN., Free PMC Article | 08/28/2021 |
| MicroRNA-203a regulates pancreatic beta cell proliferation and apoptosis by targeting IRS2. | MicroRNA-203a regulates pancreatic β cell proliferation and apoptosis by targeting IRS2.
Duan X, Zhao L, Jin W, Xiao Q, Peng Y, Huang G, Li X, DaSilva-Arnold S, Yu H, Zhou Z. | 05/22/2021 |
| Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium. | Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium.
Fernández V, Martínez-Martínez MÁ, Prieto-Colomina A, Cárdenas A, Soler R, Dori M, Tomasello U, Nomura Y, López-Atalaya JP, Calegari F, Borrell V., Free PMC Article | 04/24/2021 |
| Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics. | Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.
Hashimoto S, Maoka T, Kawata T, Mochizuki T, Koike T, Shigematsu T., Free PMC Article | 01/16/2021 |
| Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2. | Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.
Mao N, Gao D, Hu W, Gadal S, Hieronymus H, Wang S, Lee YS, Sullivan P, Zhang Z, Choi D, Rosen N, Sawyers CL, Gopalan A, Chen Y, Carver BS., Free PMC Article | 10/24/2020 |
| The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland. | The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland.
Iglesias-Osma MC, Blanco EJ, Carretero-Hernandez M, Catalano-Iniesta L, Sanchez-Robledo V, Garcia-Barrado MJ, Vicente-Garcia T, Burks DJ, Carretero J., Free PMC Article | 10/24/2020 |
| DYRK1A directly interacted with insulin receptor substrate-2 (IRS2) and promoted IRS2 phosphorylation, leading to the proteasomal degradation of IRS2 and promotion of beta cell dysfunction and apoptosis. | DYRK1A aggravates β cell dysfunction and apoptosis by promoting the phosphorylation and degradation of IRS2.
Lu M, Ma L, Shan P, Liu A, Yu X, Jiang W, Wang X, Zhao X, Ye X, Wang T. | 07/18/2020 |
| key element in spermatogenesis; silencing Irs-2 induces the sequential development of testicular atrophy | Sequential testicular atrophy involves changes in cellular proliferation and apoptosis associated with variations in aromatase P450 expression levels in Irs-2-deficient mice.
Catalano-Iniesta L, Sánchez-Robledo V, Iglesias-Osma MC, García-Barrado MJ, Carretero-Hernández M, Blanco EJ, Vicente-García T, Burks DJ, Carretero J., Free PMC Article | 06/20/2020 |
| PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin. | PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.
Besse-Patin A, Jeromson S, Levesque-Damphousse P, Secco B, Laplante M, Estall JL., Free PMC Article | 03/28/2020 |
| Irs2-deficient mice displayed obesity resistance and preservation of glucose homeostasis on high fat diet. Irs2-deficient macrophages displayed an anti-inflammatory transcriptional profile and alterations in genes involved in scavenging catecholamines and supporting increased sympathetic innervation. | Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity.
Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Irvine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ., Free PMC Article | 11/30/2019 |
| Hippo has a role in suppressing IRS2/AKT signaling prevents hepatic steatosis and liver cancer in a mouse model | Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.
Jeong SH, Kim HB, Kim MC, Lee JM, Lee JH, Kim JH, Kim JW, Park WY, Kim SY, Kim JB, Kim H, Kim JM, Choi HS, Lim DS., Free PMC Article | 07/20/2019 |
| A 174-amino-acid region in the IRS2 C-terminal tail, which is not conserved in IRS1, is required for IRS2-mediated invasion. Importantly, this "invasion (INV) region" is sufficient to confer invasion-promoting ability when swapped into IRS1. However, the INV region is not required for the IRS2-dependent regulation of glucose uptake. | Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2.
Mercado-Matos J, Janusis J, Zhu S, Chen SS, Shaw LM., Free PMC Article | 06/22/2019 |
| IRS2 plays an important role in the regulation of cell proliferation and steroidogenesis in mouse granulosa cells via the PI3K/AKT signaling pathway | IRS2 depletion inhibits cell proliferation and decreases hormone secretion in mouse granulosa cells.
Lei L, Han F, Cui Q, Liao W, Liu H, Guan G, Yang L., Free PMC Article | 02/9/2019 |
| Data (including data from studies using knockout mice) suggest that Irs2 is required to prevent insulin resistance as seen in prediabetes and hyperinsulinism; in these studies, Irs2 is required to maintain metabolic and pathological changes in adrenal gland medulla; deficiency of Irs2 leads to up-regulation of tyrosine hydroxylase and apoptosis in adrenomedullary chromaffin cells in this species. | Variations in adrenal gland medulla and dopamine effects induced by the lack of Irs2.
Catalano-Iniesta L, Iglesias-Osma MC, Sánchez-Robledo V, Carretero-Hernández M, Blanco EJ, Carretero J, García-Barrado MJ. | 01/12/2019 |
| DPP-4 inhibitor sitagliptin has effects on cardiac function, glycemia, and beta-cell function together with reducing S6K1 activation and IRS-1 and IRS-2 degradation in the obesity female mouse model | DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice.
Qiao S, Mao G, Li H, Ma Z, Hong L, Zhang H, Wang C, An J., Free PMC Article | 12/22/2018 |