| Nei-like DNA glycosylase 2 selectively antagonizes interferon-beta expression upon respiratory syncytial virus infection. | Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection.
Pan L, Xue Y, Wang K, Zheng X, Islam A, Tapryal N, Chakraborty A, Bacsi A, Ba X, Hazra TK, Boldogh I., Free PMC Article | 09/6/2023 |
| NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. | NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Hildrestrand GA, Rolseth V, Kunath N, Suganthan R, Jensen V, Bugaj AM, Fernandez-Berrocal MS, Sikko SB, Vetlesen S, Kuśnierczyk A, Olsen AK, Gützkow KB, Rowe AD, Wang W, Moldestad O, Syrstad MD, Slupphaug G, Eide L, Klungland A, Sætrom P, Luna L, Ye J, Scheffler K, Bjørås M., Free PMC Article | 01/1/2022 |
| Intrapulmonary administration of purified NEIL2 abrogates NF-kappaB-mediated inflammation. | Intrapulmonary administration of purified NEIL2 abrogates NF-κB-mediated inflammation.
Tapryal N, Shahabi S, Chakraborty A, Hosoki K, Wakamiya M, Sarkar G, Sharma G, Cardenas VJ, Boldogh I, Sur S, Ghosh G, Hazra TK., Free PMC Article | 08/21/2021 |
| DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease. | DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Scheffler K, Jalland CMO, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis MA. | 07/31/2021 |
| The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells. | The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells.
Sayed IM, Chakraborty A, Abd El-Hafeez AA, Sharma A, Sahan AZ, Huang WJM, Sahoo D, Ghosh P, Hazra TK, Das S., Free PMC Article | 04/17/2021 |
| Thus, NEIL1 and NEIL2 DNA glycosylases protect mitochondrial DNA against oxidative damage during neural crest differentiation. | NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress.
Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A, Niehrs C., Free PMC Article | 02/8/2020 |
| NEIL2 plays an important role in long term genomic maintenance | Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Chakraborty A, Wakamiya M, Venkova-Canova T, Pandita RK, Aguilera-Aguirre L, Sarker AH, Singh DK, Hosoki K, Wood TG, Sharma G, Cardenas V, Sarkar PS, Sur S, Pandita TK, Boldogh I, Hazra TK., Free PMC Article | 01/16/2016 |
| the beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity. | Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding.
Grin IR, Rieger RA, Zharkov DO., Free PMC Article | 05/3/2010 |
| NEIL1 and NEIL2 are essential in the recognition of oxidized lesions arising from 8-oxoG and may play important roles in the repair of DNA damage induced by carcinogenic metals. | Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.
Hailer MK, Slade PG, Martin BD, Rosenquist TA, Sugden KD. | 01/21/2010 |
| Keap1 recruits NEH2 through binding to ETGE and DLG motifs. | Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M., Free PMC Article | 01/21/2010 |
| Recombinant human DNA Polymerase beta and recombinant mpise NEIL2 associated with microtubules in situ and in vivo. | The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro.
Conlon KA, Miller H, Rosenquist TA, Zharkov DO, Berrios M. | 01/21/2010 |
| Results suggest a role for NEIL1 and 2 as backup deoxyribo-5'-phosphate lyases in mammalian cells. | Deoxyribophosphate lyase activity of mammalian endonuclease VIII-like proteins.
Grin IR, Khodyreva SN, Nevinsky GA, Zharkov DO. | 01/21/2010 |