| Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye. | Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
Pojer JM, Saiful Hilmi AJ, Kondo S, Harvey KF., Free PMC Article | 10/30/2021 |
| Results define a conserved role of spectrin-based mechanical support for cilium biogenesis. | Spectrin-based membrane skeleton supports ciliogenesis.
Jia R, Li D, Li M, Chai Y, Liu Y, Xie Z, Shao W, Xie C, Li L, Huang X, Chen L, Li W, Ou G., Free PMC Article | 01/25/2020 |
| a functional spectrin-integrin complex is important for regulation of the actomyosin cytoskeleton and tissue architecture | α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium.
Ng BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD, Palacios IM., Free PMC Article | 09/10/2016 |
| Alpha-pectrin regulates Hippo signaling by modulating cytoskeletal actomyosin activity. | Spectrin regulates Hippo signaling by modulating cortical actomyosin activity.
Deng H, Wang W, Yu J, Zheng Y, Qing Y, Pan D., Free PMC Article | 01/16/2016 |
| Our data provide the first rigorous test for the general requirement for tetramer-based non-erythroid spectrin networks throughout an organism and find that they have very limited roles, in direct contrast to the current paradigm | Spectrin tetramer formation is not required for viable development in Drosophila.
Khanna MR, Mattie FJ, Browder KC, Radyk MD, Crilly SE, Bakerink KJ, Harper SL, Speicher DW, Thomas GH., Free PMC Article | 04/25/2015 |
| Model in which alphabeta-spectrin directly couples lipid uptake at the plasma membrane to lipid droplet growth in the cytoplasm. In contrast, strong overexpression of beta-spectrin caused fat body atrophy and larval lethality. | Genetic studies of spectrin in the larval fat body of Drosophila melanogaster: evidence for a novel lipid uptake apparatus.
Diaconeasa B, Mazock GH, Mahowald AP, Dubreuil RR., Free PMC Article | 06/7/2014 |
| The well-characterized interaction between AE1 and the spectrin cytoskeleton in erythrocytes is not conserved in Drosophila. | The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton.
Dubreuil RR, Das A, Base C, Mazock GH., Free PMC Article | 01/22/2011 |
| Molecular mechanisms that enhance synaptic stability despite persistent disruption of the spectrin/Ank/microtubule cytoskeleton are reported. | Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton.
Massaro CM, Pielage J, Davis GW., Free PMC Article | 01/21/2010 |
| Specific regions of the spectrin molecule were tested for a role in polarized assembly and function. | Unexpected complexity in the mechanisms that target assembly of the spectrin cytoskeleton.
Das A, Base C, Manna D, Cho W, Dubreuil RR., Free PMC Article | 01/21/2010 |
| At the Drosophila neuromuscular junction postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged. | A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction.
Pielage J, Fetter RD, Davis GW., Free PMC Article | 01/21/2010 |
| Presynaptic spectrin functions as an essential presynaptic scaffold that may link synaptic cell adhesion with the stabilization of the underlying microtubule cytoskeleton. | Presynaptic spectrin is essential for synapse stabilization.
Pielage J, Fetter RD, Davis GW. | 01/21/2010 |