| A form of muscular dystrophy associated with pathogenic variants in JAG2. | A form of muscular dystrophy associated with pathogenic variants in JAG2.
Coppens S, Barnard AM, Puusepp S, Pajusalu S, Õunap K, Vargas-Franco D, Bruels CC, Donkervoort S, Pais L, Chao KR, Goodrich JK, England EM, Weisburd B, Ganesh VS, Gudmundsson S, O'Donnell-Luria A, Nigul M, Ilves P, Mohassel P, Siddique T, Milone M, Nicolau S, Maroofian R, Houlden H, Hanna MG, Quinlivan R, Beiraghi Toosi M, Ghayoor Karimiani E, Costagliola S, Deconinck N, Kadhim H, Macke E, Lanpher BC, Klee EW, Łusakowska A, Kostera-Pruszczyk A, Hahn A, Schrank B, Nishino I, Ogasawara M, El Sherif R, Stojkovic T, Nelson I, Bonne G, Cohen E, Boland-Augé A, Deleuze JF, Meng Y, Töpf A, Vilain C, Pacak CA, Rivera-Zengotita ML, Bönnemann CG, Straub V, Handford PA, Draper I, Walter GA, Kang PB., Free PMC Article | 07/3/2021 |
| Sleep Regulates Glial Plasticity and Expression of the Engulfment Receptor Draper Following Neural Injury. | Sleep Regulates Glial Plasticity and Expression of the Engulfment Receptor Draper Following Neural Injury.
Stanhope BA, Jaggard JB, Gratton M, Brown EB, Keene AC. | 06/5/2021 |
| Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain. | Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain.
Hakim-Mishnaevski K, Flint-Brodsly N, Shklyar B, Levy-Adam F, Kurant E. | 09/26/2020 |
| We find that tubular muscle subtypes are particularly sensitive to Megf10/Drpr overexpression. Complementary genetic analyses show that Megf10/Drpr and Notch may interact to regulate myogenesis. Our findings provide a basis for investigating MEGF10 in muscle development using Drosophila. | The impact of Megf10/Drpr gain-of-function on muscle development in Drosophila.
Draper I, Saha M, Stonebreaker H, Salomon RN, Matin B, Kang PB., Free PMC Article | 05/16/2020 |
| Spatial control of Draper receptor signaling initiates apoptotic cell engulfment. | Spatial control of Draper receptor signaling initiates apoptotic cell engulfment.
Williamson AP, Vale RD., Free PMC Article | 09/28/2019 |
| During metamorphosis, Draper plays a critical role in apoptotic cell clearance by glia, whereas SIMU, which is mostly expressed in pupal macrophages outside the brain, is not involved in glial phagocytosis: Draper activates Drosophila c-Jun N-terminal kinase (dJNK) signaling predominantly in the ensheathing glia and astrocytes, where it is required for efficient removal of apoptotic neurons. | Draper-mediated JNK signaling is required for glial phagocytosis of apoptotic neurons during Drosophila metamorphosis.
Hilu-Dadia R, Hakim-Mishnaevski K, Levy-Adam F, Kurant E. | 11/10/2018 |
| Glial clearance of damaged axons is significantly delayed in aged animals due to an age-dependent decline in translation of the critical glial recognition engulfment receptor Draper, which results from reduced phosphoinositide-3-kinase signalling. | Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity.
Purice MD, Speese SD, Logan MA., Free PMC Article | 08/25/2018 |
| This work identifies Draper-dependent activation of MMP-1 as a novel cascade required for proper glial clearance of severed axons. | A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade.
Purice MD, Ray A, Münzel EJ, Pope BJ, Park DJ, Speese SD, Logan MA., Free PMC Article | 05/5/2018 |
| The glial engulfment receptor Draper is protective in a Drosophila model of Alzheimer's Disease. | Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's Disease.
Ray A, Speese SD, Logan MA., Free PMC Article | 12/16/2017 |
| INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper. | Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper.
Musashe DT, Purice MD, Speese SD, Doherty J, Logan MA., Free PMC Article | 11/18/2017 |
| Src42A-Draper-Shark-mediated signaling axis is homologous to the well-established SFK-ITAM-Syk-signaling pathway used in vertebrate adaptive immune responses | Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo.
Evans IR, Rodrigues FS, Armitage EL, Wood W., Free PMC Article | 12/17/2016 |
| plays role in innate immune responses against viral infection | Protection of Insects against Viral Infection by Apoptosis-Dependent Phagocytosis.
Nainu F, Tanaka Y, Shiratsuchi A, Nakanishi Y. | 07/2/2016 |
| Our analysis of drpr mutant flies revealed muscle degeneration with fiber size variability and vacuolization, as well as reduced motor performance, features that have been observed in human MEGF10 myopathy. | Silencing of drpr leads to muscle and brain degeneration in adult Drosophila.
Draper I, Mahoney LJ, Mitsuhashi S, Pacak CA, Salomon RN, Kang PB., Free PMC Article | 05/7/2016 |
| Glia regulate steady-state numbers of Htt aggregates expressed in neurons through a clearance mechanism that requires the glial scavenger receptor Draper and downstream phagocytic machinery. | Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.
Pearce MMP, Spartz EJ, Hong W, Luo L, Kopito RR., Free PMC Article | 01/16/2016 |
| signaling through the injury-responsive Draper receptor leads to Stat92E-dependent, transcriptional activation of the draper gene | PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury.
Doherty J, Sheehan AE, Bradshaw R, Fox AN, Lu TY, Freeman MR., Free PMC Article | 12/26/2015 |
| axonal injury in the Drosophila brain activates a glial signaling pathway composed of Slipper and Tak, MKK4, dJNK and the dAP-1 complex, which ultimately leads to increased levels of Draper in glia and activation of phagocytic function. | The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function.
Macdonald JM, Doherty J, Hackett R, Freeman MR., Free PMC Article | 04/5/2014 |
| The results indicated that phosphatidylserine serves as an eat-me signal in the phagocytic removal of apoptotic cells in Drosophila and that Draper is a phosphatidylserine-binding receptor for phagocytosis. | Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper.
Tung TT, Nagaosa K, Fujita Y, Kita A, Mori H, Okada R, Nonaka S, Nakanishi Y. | 11/2/2013 |
| Draper binds to its ligand Pretaporter using EGF-like sequences, and that the NPxY motif in the intracellular region of Draper plays an essential role in its actions as an engulfment receptor. | Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila.
Fujita Y, Nagaosa K, Shiratsuchi A, Nakanishi Y. | 08/31/2013 |
| Draper is also required in engulfing follicle cells, and activates the JNK pathway | Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells.
Etchegaray JI, Timmons AK, Klein AP, Pritchett TL, Welch E, Meehan TL, Li C, McCall K., Free PMC Article | 12/22/2012 |
| Draper and integrin betanu cooperate in the phagocytic elimination of S. aureus by recognizing distinct cell wall components | Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila.
Shiratsuchi A, Mori T, Sakurai K, Nagaosa K, Sekimizu K, Lee BL, Nakanishi Y., Free PMC Article | 09/22/2012 |
| Draper (Drpr), the Drosophila homolog of C. elegans engulfment receptor CED-1, is required for autophagy induction. | The engulfment receptor Draper is required for autophagy during cell death.
McPhee CK, Baehrecke EH., Free PMC Article | 03/5/2011 |
| Draper (Drpr), the Drosophila melanogaster orthologue of the Caenorhabditis elegans engulfment receptor CED-1, is required for autophagy during cell death | Activation of autophagy during cell death requires the engulfment receptor Draper.
McPhee CK, Logan MA, Freeman MR, Baehrecke EH., Free PMC Article | 07/26/2010 |
| Pretaporter relocates from the endoplasmic reticulum to the cell surface during apoptosis to serve as a ligand for Draper in the phagocytosis of apoptotic cells | Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells.
Kuraishi T, Nakagawa Y, Nagaosa K, Hashimoto Y, Ishimoto T, Moki T, Fujita Y, Nakayama H, Dohmae N, Shiratsuchi A, Yamamoto N, Ueda K, Yamaguchi M, Awasaki T, Nakanishi Y., Free PMC Article | 01/21/2010 |
| lipoteichoic acid serves as a ligand for Draper in the phagocytosis of S. aureus by Drosophila hemocytes | Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes.
Hashimoto Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, Sekimizu K, Nakanishi Y, Shiratsuchi A. | 01/21/2010 |
| Undertaker (UTA), a Drosophila Junctophilin protein, is required for Draper (CED-1 homolog)-mediated phagocytosis. | Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis.
Cuttell L, Vaughan A, Silva E, Escaron CJ, Lavine M, Van Goethem E, Eid JP, Quirin M, Franc NC. | 01/21/2010 |