| the effects of altered Hipk expression on the nervous system and muscle, are reported. | Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function.
Wang SJH, Sinclair DAR, Kim HY, Kinsey SD, Yoo B, Shih CRY, Wong KKL, Krieger C, Harden N, Verheyen EM., Free PMC Article | 05/16/2020 |
| The authors present novel evidence that Hipk is a regulator of the JAK/STAT pathway. | Hipk is required for JAK/STAT activity during development and tumorigenesis.
Tettweiler G, Blaquiere JA, Wray NB, Verheyen EM., Free PMC Article | 04/11/2020 |
| The phosphorylation of Hbn, Ems, and Msh may provide further insight into the function of Hipk during development of the Drosophila nervous system. | Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox.
Steinmetz EL, Dewald DN, Luxem N, Walldorf U., Free PMC Article | 08/10/2019 |
| levels of Hipk on their own can promote both hyperproliferation and invasive cell behavior, suggesting that Hipk family members could be potent oncogenes and drivers of epithelial-to-mesenchymal transition . | Homeodomain-interacting protein kinase promotes tumorigenesis and metastatic cell behavior.
Blaquiere JA, Wong KKL, Kinsey SD, Wu J, Verheyen EM., Free PMC Article | 10/13/2018 |
| This study set Hipk and the master regulators Toy and Ey in an enzyme-substrate relationship. The interaction and phosphorylation of the master regulator Toy by Hipk may be important for precise tuning of signalling within the retinal determination gene network and therefore for Drosophila eye development. | Homeodomain-interacting protein kinase phosphorylates the Drosophila Paired box protein 6 (Pax6) homologues Twin of eyeless and Eyeless.
Steinmetz EL, Dewald DN, Walldorf U. | 10/6/2018 |
| Data indicate that Hipk as a repressor of both Twin of eyeless (Toy) and Eyeless (Ey). | Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression.
Blaquiere JA, Lee W, Verheyen EM. | 06/21/2014 |
| A role for Hipk in the Hippo pathway. | A role for Hipk in the Hippo pathway.
Heidary Arash E, Attisano L. | 12/14/2013 |
| Hipk proteins have a role independent of their effect on beta-catenin/Armadillo stability to enhance Wnt/Wingless signaling. | Hipk proteins dually regulate Wnt/Wingless signal transduction.
Verheyen EM, Swarup S, Lee W. | 10/20/2012 |
| Data show that Hipk dually regulates both Wingless and Hedgehog signaling by impeding the function of the E3 ubiquitin ligase complex, thereby inhibiting Armadillo ubiquitination and subsequent degradation. | Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling.
Swarup S, Verheyen EM., Free PMC Article | 10/1/2011 |
| demonstrate that Hipk is sumolylated in vivo, and its nuclear localization is dependent on the sumoylation pathway | Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.
Huang H, Du G, Chen H, Liang X, Li C, Zhu N, Xue L, Ma J, Jiao R. | 09/10/2011 |
| Hipk antagonizes Gro to promote the transmission of the Notch signal. | Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho.
Lee W, Andrews BC, Faust M, Walldorf U, Verheyen EM. | 01/21/2010 |
| Groucho phosphorylation by DHIPK2 and its dissociation from the corepressor complex play a key role in relieving the transcriptional repression of target genes regulated by Groucho | Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of Groucho.
Choi CY, Kim YH, Kim YO, Park SJ, Kim EA, Riemenschneider W, Gajewski K, Schulz RA, Kim Y. | 01/21/2010 |