| Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. | Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling.
Marom R, Zhang B, Washington ME, Song IW, Burrage LC, Rossi VC, Berrier AS, Lindsey A, Lesinski J, Nonet ML, Chen J, Baldridge D, Silverman GA, Sutton VR, Rosenfeld JA, Tran AA, Hicks MJ, Murdock DR, Dai H, Weis M, Jhangiani SN, Muzny DM, Gibbs RA, Caswell R, Pottinger C, Cilliers D, Stals K, Undiagnosed Diseases Network, Eyre D, Krakow D, Schedl T, Pak SC, Lee BH., Free PMC Article | 11/21/2023 |
| BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain. | BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain.
Tunganuntarat J, Kanjanasirirat P, Khumpanied T, Benjaskulluecha S, Wongprom B, Palaga T, Siregar TAP, Borwornpinyo S, Chaiprasert A, Palittapongarnpim P, Ponpuak M., Free PMC Article | 02/4/2023 |
| Dominantly acting KIF5B variants with pleiotropic cellular consequences cause variable clinical phenotypes. | Dominantly acting KIF5B variants with pleiotropic cellular consequences cause variable clinical phenotypes.
Flex E, Albadri S, Radio FC, Cecchetti S, Lauri A, Priolo M, Kissopoulos M, Carpentieri G, Fasano G, Venditti M, Magliocca V, Bellacchio E, Welch CL, Colombo PC, Kochav SM, Chang R, Barrick R, Trivisano M, Micalizzi A, Borghi R, Messina E, Mancini C, Pizzi S, De Santis F, Rosello M, Specchio N, Compagnucci C, McWalter K, Chung WK, Del Bene F, Tartaglia M., Free PMC Article | 01/28/2023 |
| De novo heterozygous variants in KIF5B cause kyphomelic dysplasia. | De novo heterozygous variants in KIF5B cause kyphomelic dysplasia.
Itai T, Wang Z, Nishimura G, Ohashi H, Guo L, Wakano Y, Sugiura T, Hayakawa H, Okada M, Saisu T, Kitta A, Doi H, Kurosawa K, Hotta Y, Hosono K, Sato M, Shimizu K, Takikawa K, Watanabe S, Ikeda N, Suzuki M, Fujita A, Uchiyama Y, Tsuchida N, Miyatake S, Miyake N, Matsumoto N, Ikegawa S. | 09/3/2022 |
| Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from ""first contact"" interactions in the tumor microenvironment. | Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from "first contact" interactions in the tumor microenvironment.
Charles Jacob HK, Signorelli R, Charles Richard JL, Kashuv T, Lavania S, Middleton A, Gomez BA, Ferrantella A, Amirian H, Tao J, Ergonul AB, Boone MM, Hadisurya M, Tao WA, Iliuk A, Kashyap MK, Garcia-Buitrago M, Dawra R, Saluja AK., Free PMC Article | 09/3/2022 |
| JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport. | JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport.
Celestino R, Gama JB, Castro-Rodrigues AF, Barbosa DJ, Rocha H, d'Amico EA, Musacchio A, Carvalho AX, Morais-Cabral JH, Gassmann R., Free PMC Article | 07/23/2022 |
| Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity. | Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity.
Chiba K, Ori-McKenney KM, Niwa S, McKenney RJ., Free PMC Article | 06/11/2022 |
| Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease. | Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Zhang Q, Wu L, Bai B, Li D, Xiao P, Li Q, Zhang Z, Wang H, Li L, Jiang Q., Free PMC Article | 03/19/2022 |
| Distinct Clinicopathologic Features and Possible Pathogenesis of Localized ALK-positive Histiocytosis of the Breast. | Distinct Clinicopathologic Features and Possible Pathogenesis of Localized ALK-positive Histiocytosis of the Breast.
Osako T, Kurisaki-Arakawa A, Dobashi A, Togashi Y, Baba S, Shiozawa S, Ishigame H, Ishige H, Ohno S, Ishikawa Y, Takeuchi K. | 03/12/2022 |
| Motor usage imprints microtubule stability along the shaft. | Motor usage imprints microtubule stability along the shaft.
Andreu-Carbó M, Fernandes S, Velluz MC, Kruse K, Aumeier C. | 02/12/2022 |
| Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7. | Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7.
Ferro LS, Fang Q, Eshun-Wilson L, Fernandes J, Jack A, Farrell DP, Golcuk M, Huijben T, Costa K, Gur M, DiMaio F, Nogales E, Yildiz A., Free PMC Article | 02/5/2022 |
| Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk. | Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.
Zhao L, Liu H, Luo S, Moorman PG, Walsh KM, Li W, Wei Q., Free PMC Article | 08/7/2021 |
| Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory. | Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory.
Zhao J, Fok AHK, Fan R, Kwan PY, Chan HL, Lo LH, Chan YS, Yung WH, Huang J, Lai CSW, Lai KO., Free PMC Article | 04/24/2021 |
| How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1. | How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1.
Qin J, Zhang H, Geng Y, Ji Q., Free PMC Article | 02/27/2021 |
| Run length distribution of dimerized kinesin-3 molecular motors: comparison with dimeric kinesin-1. | Run length distribution of dimerized kinesin-3 molecular motors: comparison with dimeric kinesin-1.
Guo SK, Shi XX, Wang PY, Xie P., Free PMC Article | 11/21/2020 |
| Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments. | Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments.
Henrichs V, Grycova L, Barinka C, Nahacka Z, Neuzil J, Diez S, Rohlena J, Braun M, Lansky Z., Free PMC Article | 08/29/2020 |
| Report ALK-positive histiocytosis with frequent presence of KIF5B-ALK gene fusion. | ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion.
Chang KTE, Tay AZE, Kuick CH, Chen H, Algar E, Taubenheim N, Campbell J, Mechinaud F, Campbell M, Super L, Chantranuwat C, Yuen ST, Chan JKC, Chow CW. | 05/2/2020 |
| TGF-beta mediated pro-invasive activity was found to be dependent on KIF5B expression. In contrast, the epithelial differentiation factor and EMT suppressor prolactin (PRL) was found to repress KIF5B gene expression and KIF5B-Snail1 nuclear accumulation, but enhanced KLC1 gene expression and KIF5B-KLC1 interaction. | A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
Moamer A, Hachim IY, Binothman N, Wang N, Lebrun JJ, Ali S., Free PMC Article | 01/11/2020 |
| High KIF5B expression in oral squamous cell carcinoma (OSCC) tissue specimens was significantly associated with tumor size, histological differentiation, disease recurrence, surrounding tissue invasion, recurrence time, and survival status. Kaplan-Meier cumulative survival analyses indicated that high expression of KIF5B was linked to worse overall survival and disease-free survival in OSCC. | Expression of Kif5b protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma.
Luan YJ, Xu Y, Cai J, Dou Y, Yu WJ, Wang KT, Liu SH, Yang PS, Qu X, Wei FC. | 12/14/2019 |
| these studies demonstrate that kinesin 1 regulates ciliogenesis through CCDC28B | Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.
Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, González-Sapienza G, Irigoín F, Badano JL., Free PMC Article | 11/30/2019 |
| X-ray fiber diffraction, fluorescence speckle microscopy, and second-harmonic generation microscopy, as well as cryo-EM, collectively demonstrated that the binding of nucleotide-free kinesin-1 to GDP microtubules changes the conformation of the GDP microtubule to a conformation resembling the GTP microtubule. | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport.
Shima T, Morikawa M, Kaneshiro J, Kambara T, Kamimura S, Yagi T, Iwamoto H, Uemura S, Shigematsu H, Shirouzu M, Ichimura T, Watanabe TM, Nitta R, Okada Y, Hirokawa N., Free PMC Article | 09/28/2019 |
| this is the first report of a KIF5B-ALK fusion gene in large-cell neuroendocrine carcinoma (LCNEC) . The patient was successfully treated with ALK inhibitors, suggesting that sensitivity to ALK inhibitor may define a specific LCNEC subtype. We propose that screening for ALK rearrangement in patients with LCNEC may assist in selecting potential candidates for targeted therapy. | Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase.
Shimizu N, Akashi Y, Fujii T, Shiono H, Yane K, Kitahara T, Ohta Y, Kakudo K, Wakasa T. | 01/12/2019 |
| The KIF5B-MET variant was demonstrated to have an oncogenic function in cancer cells. | Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer.
Gow CH, Liu YN, Li HY, Hsieh MS, Chang SH, Luo SC, Tsai TH, Chen PL, Tsai MF, Shih JY., Free PMC Article | 12/1/2018 |
| the discovery of kinesore, a small molecule that in vitro inhibits kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptors, yet activates kinesin-1's function of controlling microtubule dynamics in cells, demonstrating that these functions are mechanistically coupled. | A small-molecule activator of kinesin-1 drives remodeling of the microtubule network.
Randall TS, Yip YY, Wallock-Richards DJ, Pfisterer K, Sanger A, Ficek W, Steiner RA, Beavil AJ, Parsons M, Dodding MP., Free PMC Article | 07/14/2018 |
| HIV-1 did not stimulate widespread FEZ1 phosphorylation but, instead, bound microtubule (MT) affinity-regulating kinase 2 (MARK2) to stimulate FEZ1 phosphorylation on viral cores. | Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating.
Malikov V, Naghavi MH., Free PMC Article | 06/9/2018 |