| Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. | Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration.
Sugitani K, Mokuya T, Homma S, Maeda M, Konno A, Ogai K., Free PMC Article | 03/1/2023 |
| Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. | Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior.
Cao S, Dong Z, Dong X, Jia W, Zhou F, Zhao Q., Free PMC Article | 02/22/2023 |
| Sox2 expression in the visual system of two teleost species. | Sox2 expression in the visual system of two teleost species.
DeOliveira-Mello L, Lara JM, Arevalo R, Velasco A, Mack AF. | 10/24/2020 |
| these findings show that sox2 and sox3 are together required for proper otic induction, but the level of expression must be tightly regulated to avoid suppression of differentiation and maintenance of pluripotency. | sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish.
Gou Y, Guo J, Maulding K, Riley BB., Free PMC Article | 03/31/2018 |
| these data show that sox2 and sox3 exhibit intrinsic differences in promoting sensory vs. neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a and fgf8 also modify sox2/3 functions. | sox2 and sox3 Play unique roles in development of hair cells and neurons in the zebrafish inner ear.
Gou Y, Vemaraju S, Sweet EM, Kwon HJ, Riley BB., Free PMC Article | 03/31/2018 |
| Findings indicate a pivotal role for ZNF32 function in SOX2 expression and regeneration regulation. | Loss of ZNF32 augments the regeneration of nervous lateral line system through negative regulation of SOX2 transcription.
Wei Y, Li K, Yao S, Gao J, Li J, Shang Y, Zhang J, Zhang L, Li Y, Mo X, Meng W, Xiang R, Hu J, Lin P, Wei Y., Free PMC Article | 03/3/2018 |
| Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration. | Retinoic Acid Signaling Mediates Hair Cell Regeneration by Repressing p27kip and sox2 in Supporting Cells.
Rubbini D, Robert-Moreno À, Hoijman E, Alsina B., Free PMC Article | 03/19/2016 |
| a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury | Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish.
Ogai K, Nakatani K, Hisano S, Sugitani K, Koriyama Y, Kato S. | 09/26/2015 |
| Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. | Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus.
Pavlou S, Astell K, Kasioulis I, Gakovic M, Baldock R, van Heyningen V, Coutinho P., Free PMC Article | 10/18/2014 |
| By western blot three protein bands of 28 kDa, 34 kDa (main band), and 38 kDa were detected in the brain of animals 180 days post-fertilizaton. | Developmental changes in the expression of Sox2 in the zebrafish brain.
Germanà A, Montalbano G, Guerrera MC, Amato V, Laurà R, Magnoli D, Campo S, Suarez-Fernandez E, Ciriaco E, Vega JA. | 04/26/2014 |
| significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos. | Effect of chilling on sox2, sox3 and sox19a gene expression in zebrafish (Danio rerio) embryos.
Desai K, Spikings E, Zhang T. | 01/21/2012 |
| Knockdown of the four B1 sox genes sox2/3/19a/19b resulted in severe developmental abnormalities. | B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo.
Okuda Y, Ogura E, Kondoh H, Kamachi Y., Free PMC Article | 09/6/2010 |
| sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration | Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear.
Millimaki BB, Sweet EM, Riley BB., Free PMC Article | 04/12/2010 |
| shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs | Sox-2 in taste bud and lateral line system of zebrafish during development.
Germanà A, Montalbano G, Guerrera MC, Laura R, Levanti M, Abbate F, de Carlos F, Vega JA, Ciriaco E. | 03/1/2010 |
| Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters. | Complex architecture and regulated expression of the Sox2ot locus during vertebrate development.
Amaral PP, Neyt C, Wilkins SJ, Askarian-Amiri ME, Sunkin SM, Perkins AC, Mattick JS., Free PMC Article | 01/21/2010 |
| zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line | Regeneration in zebrafish lateral line neuromasts: expression of the neural progenitor cell marker sox2 and proliferation-dependent and-independent mechanisms of hair cell renewal.
Hernández PP, Olivari FA, Sarrazin AF, Sandoval PC, Allende ML. | 01/21/2010 |