| Investigating the Impact of Electrostatic Interactions on Calmodulin Binding and Ca[2+]-Dependent Activation of the Calcium-Gated Potassium SK4 Channel. | Investigating the Impact of Electrostatic Interactions on Calmodulin Binding and Ca(2+)-Dependent Activation of the Calcium-Gated Potassium SK4 Channel.
Segura É, Zhao J, Broszczak M, Audet F, Sauvé R, Parent L., Free PMC Article | 05/14/2024 |
| Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability. | Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability.
Nikitin ES, Postnikova TY, Proskurina EY, Borodinova AA, Ivanova V, Roshchin MV, Smirnova MP, Kelmanson I, Belousov VV, Balaban PM, Zaitsev AV. | 03/18/2024 |
| The Gardos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells. | The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells.
Petkova-Kirova P, Murciano N, Iacono G, Jansen J, Simionato G, Qiao M, Van der Zwaan C, Rotordam MG, John T, Hertz L, Hoogendijk AJ, Becker N, Wagner C, Von Lindern M, Egee S, Van den Akker E, Kaestner L., Free PMC Article | 02/22/2024 |
| A single coiled-coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1:hIKCa channels. | A single coiled-coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1:hIKCa channels.
Charlick JN, Bozadzhieva D, Butler AS, Wilkinson KA, Marrion NV., Free PMC Article | 01/31/2024 |
| KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation. | KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation.
Ran L, Ye T, Erbs E, Ehl S, Spassky N, Sumara I, Zhang Z, Ricci R. | 01/3/2024 |
| Pancreatic KCa3.1 channels in health and disease. | Pancreatic K(Ca)3.1 channels in health and disease.
Soret B, Hense J, Lüdtke S, Thale I, Schwab A, Düfer M. | 03/17/2023 |
| Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel KCa3.1 in THP-1-Derived M2 Macrophages. | Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages.
Ohya S, Matsui M, Kajikuri J, Kito H, Endo K., Free PMC Article | 08/27/2022 |
| KCNN4 Promotes the Stemness Potentials of Liver Cancer Stem Cells by Enhancing Glucose Metabolism. | KCNN4 Promotes the Stemness Potentials of Liver Cancer Stem Cells by Enhancing Glucose Metabolism.
Fan J, Tian R, Yang X, Wang H, Shi Y, Fan X, Zhang J, Chen Y, Zhang K, Chen Z, Li L., Free PMC Article | 07/23/2022 |
| KCNN4 promotes the progression of lung adenocarcinoma by activating the AKT and ERK signaling pathways. | KCNN4 promotes the progression of lung adenocarcinoma by activating the AKT and ERK signaling pathways.
Xu P, Mo X, Xia R, Jiang L, Zhang C, Xu H, Sun Q, Zhou G, Zhang Y, Wang Y, Xia H. | 12/25/2021 |
| SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer. | SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer.
Ibrahim S, Chaigne J, Dakik H, Fourbon Y, Corset L, Lecomte T, Raoul W, Guéguinou M. | 12/11/2021 |
| KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This Might Be a Novel Marker and Therapeutic Option Targeting Potassium Channels. | KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This Might Be a Novel Marker and Therapeutic Option Targeting Potassium Channels.
Süss C, Broncy L, Pollinger K, Kunst C, Gülow K, Müller M, Wölfel G. | 10/9/2021 |
| Altered KCa3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation. | Altered K(Ca)3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation.
Seo CH, Cui HS, Kim JB. | 10/2/2021 |
| TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase. | TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase.
Ferrera L, Barbieri R, Picco C, Zuccolini P, Remigante A, Bertelli S, Fumagalli MR, Zifarelli G, La Porta CAM, Gavazzo P, Pusch M., Free PMC Article | 09/25/2021 |
| ATP-evoked intracellular Ca(2+) transients shape the ionic permeability of human microglia from epileptic temporal cortex. | ATP-evoked intracellular Ca(2+) transients shape the ionic permeability of human microglia from epileptic temporal cortex.
Palomba NP, Martinello K, Cocozza G, Casciato S, Mascia A, Di Gennaro G, Morace R, Esposito V, Wulff H, Limatola C, Fucile S., Free PMC Article | 09/11/2021 |
| Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection. | Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection.
Vigneault P, Parent S, Kanda P, Michie C, Davis DR, Nattel S., Free PMC Article | 09/4/2021 |
| KCa3.1-dependent uptake of the cytotoxic DNA-binding dye Hoechst 33258 into cancerous but not healthy cervical cells. | K(Ca)3.1-dependent uptake of the cytotoxic DNA-binding dye Hoechst 33258 into cancerous but not healthy cervical cells.
Bukhari M, Deng H, Sipes D, Ruane-Foster M, Purdy K, Woodworth CD, Sur S, Samways DSK., Free PMC Article | 08/7/2021 |
| Study on mechanism of down-regulating ikca1 molecule affecting the increment of oral squamous cell carcinoma. | Study on mechanism of down-regulating ikca1 molecule affecting the increment of oral squamous cell carcinoma.
Liu J, Guo Y. | 06/5/2021 |
| KCNN4 is a diagnostic and prognostic biomarker that promotes papillary thyroid cancer progression. | KCNN4 is a diagnostic and prognostic biomarker that promotes papillary thyroid cancer progression.
Wen J, Lin B, Lin L, Chen Y, Wang O., Free PMC Article | 04/24/2021 |
| In KCNN4-related disease, the main symptoms were more severe anemia, hemolysis and iron overload, with no clear sign of red cell dehydration; therefore, this disorder would be better described as a 'Gardos channelopathy'. | Clinical and biological features in PIEZO1-hereditary xerocytosis and Gardos channelopathy: a retrospective series of 126 patients.
Picard V, Guitton C, Thuret I, Rose C, Bendelac L, Ghazal K, Aguilar-Martinez P, Badens C, Barro C, Bénéteau C, Berger C, Cathébras P, Deconinck E, Delaunay J, Durand JM, Firah N, Galactéros F, Godeau B, Jaïs X, de Jaureguiberry JP, Le Stradic C, Lifermann F, Maffre R, Morin G, Perrin J, Proulle V, Ruivard M, Toutain F, Lahary A, Garçon L., Free PMC Article | 07/25/2020 |
| High KCa3.1 Expression is associated with Active Ulcerative Colitis. | Clinical Significance of Potassium Channel and NLRP3 Expression in Platelets of Active Ulcerative Colitis.
Mei Y, Ye S, Han W, Yang Q, Hu C, Liu X, Mei Q, Xu J. | 06/6/2020 |
| Chronic KCNN4-driven red cell dehydration and intracellular cation imbalance can lead to reduced KCNN4 activity in hereditary xerocytosis and wild type red cells. | Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells.
Rivera A, Vandorpe DH, Shmukler BE, Andolfo I, Iolascon A, Archer NM, Shabani E, Auerbach M, Hamerschlak N, Morton J, Wohlgemuth JG, Brugnara C, Snyder LM, Alper SL. | 03/28/2020 |
| Data demonstrate that IKCa and SK1 subunits prefer to form heteromeric channels when coexpressed in a heterologous system that will alter their responsiveness to pharmacological tools typically used to define their expression pattern. | Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca(2+)-Activated Potassium Channels.
Higham J, Sahu G, Wazen RM, Colarusso P, Gregorie A, Harvey BSJ, Goudswaard L, Varley G, Sheppard DN, Turner RW, Marrion NV. | 12/14/2019 |
| Study found that the expression of KCa3.1 was significantly elevated in poorly differentiated hepatocellular carcinoma (HCC) tissues and could promote cell proliferation, migration, and invasion. Mechanistically, KCa3.1 promoted cell cycle progression and migration and invasion of HCC cells by SKP2 to trigger the degradation of p21 and p27 and targeting RELN to induce epithelial-mesenchymal transition. | The potassium channel KCa3.1 promotes cell proliferation by activating SKP2 and metastasis through the EMT pathway in hepatocellular carcinoma.
Du Y, Song W, Chen J, Chen H, Xuan Z, Zhao L, Chen J, Jin C, Zhou M, Tuo B, Zhao Y, Zheng S, Song P. | 11/2/2019 |
| DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination. | Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination.
Hasso-Agopsowicz M, Scriba TJ, Hanekom WA, Dockrell HM, Smith SG., Free PMC Article | 10/26/2019 |
| Kca3.1 channel protein (KCa3.1) channel activity is reduced in head and neck squamous cell carcinoma (HNSCC) CD8+ T cells. | A defect in KCa3.1 channel activity limits the ability of CD8(+) T cells from cancer patients to infiltrate an adenosine-rich microenvironment.
Chimote AA, Balajthy A, Arnold MJ, Newton HS, Hajdu P, Qualtieri J, Wise-Draper T, Conforti L., Free PMC Article | 09/28/2019 |