| Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era. | Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.
Bentley SR, Guella I, Sherman HE, Neuendorf HM, Sykes AM, Fowdar JY, Silburn PA, Wood SA, Farrer MJ, Mellick GD., Free PMC Article | 07/31/2021 |
| KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma. | KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma.
Nakamura S, Kanda M, Koike M, Shimizu D, Umeda S, Hattori N, Hayashi M, Tanaka C, Kobayashi D, Yamada S, Omae K, Kodera Y. | 03/13/2021 |
| KCNJ15 couples with polyamines in sensing weak electric fields. | KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.
Nakajima KI, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M., Free PMC Article | 06/28/2016 |
| RNA-seq evidence of biallelic expression of KCNJ15 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of KCNJ15 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. | Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
Alves da Silva AF, Machado FB, Pavarino ÉC, Biselli-Périco JM, Zampieri BL, da Silva Francisco Junior R, Mozer Rodrigues PT, Terra Machado D, Santos-Rebouças CB, Gomes Fernandes M, Chuva de Sousa Lopes SM, Lopes Rios ÁF, Medina-Acosta E., Free PMC Article | 05/9/2016 |
| KCNJ15 has a major role in histamine-stimulated gastric acid secretion. | Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion.
Yuan J, Liu W, Karvar S, Baker SS, He W, Baker RD, Ji G, Xie J, Zhu L. | 10/31/2015 |
| We had performed a replication study using an independent larger Japanese population for the association of rs3746876 within KCNJ15, and observed a significant association of rs3746876 with type 2 diabetes, but this study failed to find original finding. | Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population.
Fukuda H, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S. | 02/15/2014 |
| It was shown that downregulation of Kcnj15 leads to increased insulin secretion in vitro and in vivo. The mechanism for regulating insulin secretion inolved a calcium-sensiong receptor. | Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes.
Okamoto K, Iwasaki N, Doi K, Noiri E, Iwamoto Y, Uchigata Y, Fujita T, Tokunaga K., Free PMC Article | 09/15/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.
Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K, Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K., Free PMC Articles: PMC2801752, PMC2801752 | 04/7/2010 |
| KCNJ15 is a previously unreported susceptibility gene for T2DM among Asians | Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.
Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K, Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K., Free PMC Articles: PMC2801752, PMC2801752 | 03/1/2010 |
| MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions. | MUPP1 complexes renal K+ channels to alter cell surface expression and whole cell currents.
Sindic A, Huang C, Chen AP, Ding Y, Miller-Little WA, Che D, Romero MF, Miller RT., Free PMC Article | 01/21/2010 |
| maintaining electrical integrity of bile-generating hepatocytes. | Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel.
Hill CE, Briggs MM, Liu J, Magtanong L. | 01/21/2010 |
| Calcium-sensing receptor interacts directly with Kir4.1 and Kir4.2 and can decrease their currents. | Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function.
Huang C, Sindic A, Hill CE, Hujer KM, Chan KW, Sassen M, Wu Z, Kurachi Y, Nielsen S, Romero MF, Miller RT. | 01/21/2010 |
| The potential synergy and consequences of the overexpression of KIR4.2 and KIR3.2 in Down's syndrome brain development are discussed. | Chromosome 21 KIR channels in brain development.
Thiery E, Thomas S, Vacher S, Delezoide AL, Delabar JM, Créau N. | 01/21/2010 |