| Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion. | Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion.
Chaudhari K, Gorla M, Chang C, Kania A, Bashaw GJ., Free PMC Article | 10/30/2021 |
| Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3. | Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3.
Daiber T, VanderZwan-Butler CJ, Bashaw GJ, Evans TA., Free PMC Article | 09/4/2021 |
| Results indicate that each of the Drosophila Roundabout (Robo1) Fibronectin (Fn) repeats are individually dispensable for the protein's role in midline repulsion. | In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.
Brown HE, Reichert MC, Evans TA., Free PMC Article | 10/13/2018 |
| Vascular cells produce Slit that activates Robo receptors in the posterior signalling centre of the larval haematopoietic organ, the lymph gland. | Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling.
Morin-Poulard I, Sharma A, Louradour I, Vanzo N, Vincent A, Crozatier M., Free PMC Article | 09/22/2018 |
| Mmy is required for Slit secretion and for maintaining Robo abundance and distribution in the developing nervous system in Drosophila. | The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons.
Manavalan MA, Jayasinghe VR, Grewal R, Bhat KM., Free PMC Article | 04/7/2018 |
| Dscam1 appears to modify the output of Robo and Slit complexes so that signaling is no longer repulsive | Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.
Alavi M, Song M, King GL, Gillis T, Propst R, Lamanuzzi M, Bousum A, Miller A, Allen R, Kidd T., Free PMC Article | 03/31/2018 |
| loss of Atg16 or its binding partner Rab19 impairs Slit production, which normally inhibits enteroendocrine cell generation by activating Robo signaling in stem cells. | Drosophila Atg16 promotes enteroendocrine cell differentiation via regulation of intestinal Slit/Robo signaling.
Nagy P, Szatmári Z, Sándor GO, Lippai M, Hegedűs K, Juhász G. | 11/18/2017 |
| Findings indicate that four of the five immunoglobulin-like (Ig) domains within Drosophila Robo1 are dispensable for its role in midline repulsion, despite their strong evolutionary conservation, and highlight a unique requirement for the Slit-binding Ig1 domain in the regulation of midline crossing. | In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains.
Reichert MC, Brown HE, Evans TA., Free PMC Article | 09/23/2017 |
| FruBM employs the Robo1 pathway for formation of the male-specific ipsilateral neurite | Fruitless Represses robo1 Transcription to Shape Male-Specific Neural Morphology and Behavior in Drosophila.
Ito H, Sato K, Kondo S, Ueda R, Yamamoto D. | 06/24/2017 |
| Deleting Ig1 from Robo1 disrupts Slit binding in cultured Drosophila cells. Robo1 variant lacking Ig1 (Robo1Ig1) is unable to promote ectopic midline repulsion. | Slit Binding via the Ig1 Domain Is Essential for Midline Repulsion by Drosophila Robo1 but Dispensable for Receptor Expression, Localization, and Regulation in Vivo.
Brown HE, Reichert MC, Evans TA., Free PMC Article | 08/20/2016 |
| data strongly suggest the model that clathrin-dependent endocytosis of robo in response to Slip is critical in transmitting robo's repulsive signal across the cell membrane | Signaling from Within: Endocytic Trafficking of the Robo Receptor Is Required for Midline Axon Repulsion.
Charron F., Free PMC Article | 06/4/2016 |
| data support a model in which Robo's ligand-dependent internalization from cell surface to late endosome is essential for receptor activation and proper repulsive guidance at the midline by allowing recruitment of the downstream effector Son of Sevenless | Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion.
Chance RK, Bashaw GJ., Free PMC Article | 06/4/2016 |
| The authors describe a distinct mechanism to inhibit Robo1 repulsion and promote midline crossing, in which Roundabout2 (Robo2) binds to and prevents Robo1 signaling. | Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons.
Evans TA, Santiago C, Arbeille E, Bashaw GJ., Free PMC Article | 04/9/2016 |
| Our work indicates that Slit-Robo signaling affects stem cell function downstream of the JAK-STAT pathway by controlling the ability of stem cells to compete for occupancy in their niche. | Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis.
Stine RR, Greenspan LJ, Ramachandran KV, Matunis EL., Free PMC Article | 11/14/2015 |
| these findings show that the polarized localization of Mp controls the direction, timing, and presumably the extent of Slit/Robo activity and signaling at the luminal membrane of the heart cardioblasts. | Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen.
Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T., Free PMC Article | 09/14/2013 |
| a novel, dose-dependent role for Robo in regulating microvilli growth | Roundabout is required in the visceral mesoderm for proper microvillus length in the hindgut epithelium.
Soplop NH, Cheng YS, Kramer SG., Free PMC Article | 04/27/2013 |
| Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 specify the position of longitudinal axon pathways. | Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.
Evans TA, Bashaw GJ., Free PMC Article | 05/26/2012 |
| the Slit/Roundabout pathway, best known for its role in regulating axonal guidance, is essential for proper gonad formation | A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway.
Weyers JJ, Milutinovich AB, Takeda Y, Jemc JC, Van Doren M., Free PMC Article | 07/2/2011 |
| diverse responses to the Slit guidance cue are imparted by intrinsic structural differences encoded in the extracellular Ig domains of the Robo receptors | Functional diversity of Robo receptor immunoglobulin domains promotes distinct axon guidance decisions.
Evans TA, Bashaw GJ., Free PMC Article | 07/5/2010 |
| Neurexin IV, Robo, Slit, and other associated proteins form a macromolecular signaling complex that allows efficient repulsive midline axon guidance. | Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance.
Banerjee S, Blauth K, Peters K, Rogers SL, Fanning AS, Bhat MA., Free PMC Article | 05/10/2010 |
| Study found that lateral positioning does not rely on structural differences between the Robo1 and Robo2 receptors-neither in their ectodomain nor cytoplasmic domains instead expression differences alone can account for lateral pathway selection. | Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors.
Spitzweck B, Brankatschk M, Dickson BJ. | 03/8/2010 |
| Data demonstrate that the roundabout also regulate midline crossing by gustatory receptor neuron axons. | Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors.
Mellert DJ, Knapp JM, Manoli DS, Meissner GW, Baker BS., Free PMC Article | 01/21/2010 |
| the medio-lateral positioning of motoneuron dendrites in the leg neuropil is controlled by the midline signalling systems Slit-Robo and Netrin-Fra. | Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map.
Brierley DJ, Blanc E, Reddy OV, Vijayraghavan K, Williams DW., Free PMC Article | 01/21/2010 |
| the midline signalling systems Slit/Robo and Netrin/Frazzled are the main molecular mechanisms that underlie dendritic targeting with respect to the midline. | Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system.
Mauss A, Tripodi M, Evers JF, Landgraf M., Free PMC Article | 01/21/2010 |
| Data suggest a novel mechanism by which muscles are targeted towards tendon cells as a result of a tendon-specific leucine-rich repeat protein-Robo interactions. | LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo.
Wayburn B, Volk T. | 01/21/2010 |