| Plakoglobin regulates adipocyte differentiation independently of the Wnt/beta-catenin signaling pathway. | Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signaling pathway.
Abou Azar F, Mugabo Y, Yuen S, Del Veliz S, Paré F, Rial SA, Lavoie G, Roux PP, Lim GE. | 04/25/2024 |
| TRIM50 Inhibits Gastric Cancer Progression by Regulating the Ubiquitination and Nuclear Translocation of JUP. | TRIM50 Inhibits Gastric Cancer Progression by Regulating the Ubiquitination and Nuclear Translocation of JUP.
Hu J, Huang R, Liang C, Wang Y, Wang M, Chen Y, Wu C, Zhang J, Liu Z, Zhao Q, Liu Z, Wang F, Yuan S., Free PMC Article | 10/4/2023 |
| Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB. | Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB.
Li Y, Xu W, Ren Y, Cheung HC, Huang P, Kaur G, Kuo CJ, McDonough SP, Fubini SL, Lipkin SM, Deng X, Chang YF, Huang L., Free PMC Article | 11/5/2022 |
| ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-kappaB signaling pathway. | ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway.
Wang Z, Hu J, Chen J, Zhang J, Li W, Tian Y, Liu H, Yang X., Free PMC Article | 10/15/2022 |
| Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets. | Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets.
Spethmann T, Böckelmann LC, Labitzky V, Ahlers AK, Schröder-Schwarz J, Bonk S, Simon R, Sauter G, Huland H, Kypta R, Schumacher U, Lange T., Free PMC Article | 04/9/2022 |
| KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway. | KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway.
Yin L, Li Q, Mrdenovic S, Chu GC, Wu BJ, Bu H, Duan P, Kim J, You S, Lewis MS, Liang G, Wang R, Zhau HE, Chung LWK., Free PMC Article | 03/19/2022 |
| Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma. | Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma.
Guo H, Wang S, Xie A, Sun W, Wei C, Xian S, Yin H, Li M, Sun H, Li H, Meng T, Zhang J, Huang Z., Free PMC Article | 02/26/2022 |
| JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes. | JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes.
Negoita F, Vavakova M, Säll J, Laurencikiene J, Göransson O. | 12/4/2021 |
| Junction plakoglobin regulates and destabilizes HIF2alpha to inhibit tumorigenesis of renal cell carcinoma. | Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma.
Chen K, Zeng J, Sun Y, Ouyang W, Yu G, Zhou H, Zhang Y, Yao W, Xiao W, Hu J, Xing J, Xiao K, Wu L, Chen Z, Ye Z, Xu H., Free PMC Article | 10/23/2021 |
| Arrhythmogenic right ventricular cardiomyopathy in patients with biallelic JUP-associated skin fragility. | Arrhythmogenic right ventricular cardiomyopathy in patients with biallelic JUP-associated skin fragility.
Vahidnezhad H, Youssefian L, Faghankhani M, Mozafari N, Saeidian AH, Niaziorimi F, Abdollahimajd F, Sotoudeh S, Rajabi F, Mirsafaei L, Sani ZA, Liu L, Guy A, Zeinali S, Kariminejad A, Ho RT, McGrath JA, Uitto J., Free PMC Article | 05/22/2021 |
| Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1. | Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Fang Y, Li F, Qi C, Mao X, Xu Y, Zhao Z, Wu H, Zhang Z. | 02/13/2021 |
| FLG and DST support melanoma cell growth in vitro and in vivo. Growth effects of JUP were only evident in vivo, and may be mediated, in part, by enhancing angiogenesis. In addition, growth-promoting effects of FLG and DST in vitro suggest that these genes may also support melanoma cell proliferation through angiogenesis-independent pathways. | The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis.
Leick KM, Rodriguez AB, Melssen MM, Benamar M, Lindsay RS, Eki R, Du KP, Parlak M, Abbas T, Engelhard VH, Slingluff CL Jr., Free PMC Article | 03/7/2020 |
| gamma-catenin signaling is involved in the initiation and maintenance of BCR-ABL1(+) B-cell acute lymphoblastic leukemia. | γ-Catenin-Dependent Signals Maintain BCR-ABL1(+) B Cell Acute Lymphoblastic Leukemia.
Luong-Gardiol N, Siddiqui I, Pizzitola I, Jeevan-Raj B, Charmoy M, Huang Y, Irmisch A, Curtet S, Angelov GS, Danilo M, Juilland M, Bornhauser B, Thome M, Hantschel O, Chalandon Y, Cazzaniga G, Bourquin JP, Huelsken J, Held W. | 02/8/2020 |
| revealed that JUP was overexpressed in oral squamous cell carcinoma (OSCC), and that JUP promoted the proliferation, migration, and invasion of OSCC cells and inhibited apoptosis | Junction plakoglobin, a potential prognostic marker of oral squamous cell carcinoma, promotes proliferation, migration and invasion.
Fang J, Xiao L, Zhang Q, Peng Y, Wang Z, Liu Y. | 02/1/2020 |
| Ectopic expression of HDAC7 suppresses mRNA and protein levels of plakoglobin in lung cancer cells, whereas silencing HDAC7 increases the the expression of plakoglobin. Overexpression of plakoglobin significantly reduces the enhanced cell proliferation, migration and invasion induced by ectopic HDAC7. HDAC7 suppresses plakoglobin by directly binding to its promoter. | Histone deacetylase 7 inhibits plakoglobin expression to promote lung cancer cell growth and metastasis.
Sang Y, Sun L, Wu Y, Yuan W, Liu Y, Li SW. | 05/25/2019 |
| NEDD9, E-cadherin and gamma-catenin proteins have roles in pancreatic ductal adenocarcinoma | Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC).
Radulović P, Krušlin B., Free PMC Article | 12/22/2018 |
| gamma-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer. | γ-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer.
Nagel JM, Lahm H, Ofner A, Göke B, Kolligs FT. | 07/21/2018 |
| Data show that plakoglobin interacted with p53R175H and decreased beta-catenin protein levels. | Plakoglobin restores tumor suppressor activity of p53(R175H) mutant by sequestering the oncogenic potential of β-catenin.
Alaee M, Nool K, Pasdar M., Free PMC Article | 06/23/2018 |
| FBW7 cooperated with gamma-catenin to inhibit G2/M cell cycle transition and cell proliferation. | FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation.
Li Y, Hu K, Xiao X, Wu W, Yan H, Chen H, Chen Z, Yin D. | 04/7/2018 |
| These results suggest that a major role of 14-3-3gamma in desmosome assembly is to transport PG to the cell border leading to the initiation of desmosome formation. | Plakoglobin localization to the cell border restores desmosome function in cells lacking 14-3-3γ.
Vishal SS, Tilwani S, Dalal SN. | 02/17/2018 |
| We showed that p53 and PG cooperatively reduced growth and acted synergistically to decrease cellular migration and invasion | The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion.
Alaee M, Padda A, Mehrabani V, Churchill L, Pasdar M., Free PMC Article | 01/6/2018 |
| High plakoglobin expression is associated with lung adenocarcinoma. | The expression of plakoglobin is a potential prognostic biomarker for patients with surgically resected lung adenocarcinoma.
He X, Zhou T, Yang G, Fang W, Li Z, Zhan J, Zhao Y, Cheng Z, Huang Y, Zhao H, Zhang L., Free PMC Article | 12/16/2017 |
| Knockdown of GATA6 completely eliminated the effect of TCF1, while forced expression of GATA6 induced hESC differentiation | β-catenin coordinates with Jup and the TCF1/GATA6 axis to regulate human embryonic stem cell fate.
Sun H, Wang X, Liu K, Guo M, Zhang Y, Ying QL, Ye S. | 11/11/2017 |
| Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB) protein (CBP)/beta-catenin or gamma-catenin interaction. | CBP/Catenin antagonists: Targeting LSCs' Achilles heel.
Kim YM, Gang EJ, Kahn M., Free PMC Article | 10/28/2017 |
| Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin | Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin.
Muramatsu F, Kidoya H, Naito H, Hayashi Y, Iba T, Takakura N. | 10/14/2017 |